 DNA Ligase ATP
"DNA Ligase ATP" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
ATP-dependent cellular enzyme which catalyzes DNA replication, repair and recombination through formation of internucleotide ester bonds between phosphate and deoxyribose moieties. Vertebrate cells encode three well-characterized DNA ligases, DNA ligase I, III and IV, all of which are related in structure and sequence. DNA ligases either require ATP or NAD. However, archaebacterial, viral, and some eubacterial DNA ligases are ATP-dependent.
| Descriptor ID |
D000072481
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| MeSH Number(s) |
D08.811.074.500.500 D08.811.464.754.600.500
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| Concept/Terms |
DNA Ligase ATP- DNA Ligase ATP
- ATP, DNA Ligase
- Ligase ATP, DNA
- Polydeoxyribonucleotide Synthase ATP
- ATP, Polydeoxyribonucleotide Synthase
- Synthase ATP, Polydeoxyribonucleotide
- DNA Ligases, ATP-Dependent
- ATP-Dependent DNA Ligases
- DNA Ligases, ATP Dependent
- Ligases, ATP-Dependent DNA
DNA Ligase IIIalpha- DNA Ligase IIIalpha
- IIIalpha, DNA Ligase
- Ligase IIIalpha, DNA
- LIGIIIalpha Protein
DNA Ligase III- DNA Ligase III
- Ligase III, DNA
- DNA Ligase II
- Ligase II, DNA
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Below are MeSH descriptors whose meaning is more general than "DNA Ligase ATP".
Below are MeSH descriptors whose meaning is more specific than "DNA Ligase ATP".
This graph shows the total number of publications written about "DNA Ligase ATP" by people in this website by year, and whether "DNA Ligase ATP" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Ligase ATP" by people in Profiles.
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Maffucci P, Chavez J, Jurkiw TJ, O'Brien PJ, Abbott JK, Reynolds PR, Worth A, Notarangelo LD, Felgentreff K, Cortes P, Boisson B, Radigan L, Cobat A, Dinakar C, Ehlayel M, Ben-Omran T, Gelfand EW, Casanova JL, Cunningham-Rundles C. Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies. J Clin Invest. 2018 12 03; 128(12):5489-5504.
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Lohman GJ, Bauer RJ, Nichols NM, Mazzola L, Bybee J, Rivizzigno D, Cantin E, Evans TC. A high-throughput assay for the comprehensive profiling of DNA ligase fidelity. Nucleic Acids Res. 2016 Jan 29; 44(2):e14.
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Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med. 2010 Feb 15; 207(2):417-27.
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Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley KM, Detre C, Keszei M, Walter JE, Feldman L, Cheng HL, Poliani PL, Wang JH, Balter BB, Recher M, Andersson EM, Zha S, Giliani S, Terhorst C, Alt FW, Yan CT. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3024-9.
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Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3034-9.
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Johnson A, O'Donnell M. DNA ligase: getting a grip to seal the deal. Curr Biol. 2005 Feb 08; 15(3):R90-2.
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Baumann P, Cech TR. Protection of telomeres by the Ku protein in fission yeast. Mol Biol Cell. 2000 Oct; 11(10):3265-75.
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