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Sujatha Jagannathan

TitleAssistant Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics
    Other Positions
    TitleAssoc Chair
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-BioChem&Molecular Genetics


    Collapse Biography 
    Collapse education and training
    Duke University, Durham, NC, USAPh. D. 05/2013Cell Biology
    Fred Hutchinson Cancer Research Center, Seattle, WA, USAPostdoctoral fellowship12/2017mRNA surveillance
    Center for Biotechnology, Anna University, Chennai, IndiaB. Tech05/2006Industrial Biotechnology

    Collapse Overview 
    Collapse overview
    Our lab studies how cells detect and degrade aberrant RNAs, and how dysregulation of this surveillance process contributes to human muscle development and disease.

    More information about our work can be found on our lab website: www.jagannathan-lab.org

    Collapse Research 
    Collapse research activities and funding
    R35GM133433     (JAGANNATHAN, SUJATHA)Aug 1, 2019 - Jul 31, 2024
    NIH
    Understanding the variability in nonsense-mediated RNA decay
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kolakada D, Fu R, Biziaev N, Shuvalov A, Lore M, Campbell AE, Cort?zar MA, Sajek MP, Hesselberth JR, Mukherjee N, Alkalaeva E, Coban Akdemir ZH, Jagannathan S. Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay. bioRxiv. 2024 Nov 10. PMID: 38260612.
      View in: PubMed
    2. Kolakada D, Campbell AE, Baquero Galvis L, Li Z, Lore M, Jagannathan S. A system of reporters for comparative investigation of EJC-independent and EJC-enhanced nonsense-mediated mRNA decay. bioRxiv. 2023 Nov 15. PMID: 38014198.
      View in: PubMed
    3. Hamm DC, Paatela EM, Bennett SR, Wong CJ, Campbell AE, Wladyka CL, Smith AA, Jagannathan S, Hsieh AC, Tapscott SJ. The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs. PLoS Biol. 2023 09; 21(9):e3002317. PMID: 37747887.
      View in: PubMed
    4. Mu?oz O, Lore M, Jagannathan S. The long and short of EJC-independent nonsense-mediated RNA decay. Biochem Soc Trans. 2023 06 28; 51(3):1121-1129. PMID: 37145092.
      View in: PubMed
    5. Campbell AE, Dyle MC, Albanese R, Matheny T, Sudheendran K, Cort?zar MA, Forman T, Fu R, Gillen AE, Caruthers MH, Floor SN, Calviello L, Jagannathan S. Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression. Cell Rep. 2023 06 27; 42(6):112642. PMID: 37314931.
      View in: PubMed
    6. Sherlock ME, Baquero Galvis L, Vicens Q, Kieft JS, Jagannathan S. Principles, mechanisms, and biological implications of translation termination-reinitiation. RNA. 2023 07; 29(7):865-884. PMID: 37024263.
      View in: PubMed
    7. Campbell AE, Arjomand J, King OD, Tawil R, Jagannathan S. A Targeted Approach for Evaluating DUX4-Regulated Proteins as Potential Serum Biomarkers for Facioscapulohumeral Muscular Dystrophy Using Immunoassay Proteomics. J Neuromuscul Dis. 2023; 10(6):1031-1040. PMID: 37899061.
      View in: PubMed
    8. Jagannathan S. The evolution of DUX4 gene regulation and its implication for facioscapulohumeral muscular dystrophy. Biochim Biophys Acta Mol Basis Dis. 2022 05 01; 1868(5):166367. PMID: 35158020.
      View in: PubMed
    9. Jagannathan S, de Greef JC, Hayward LJ, Yokomori K, Gabellini D, Mul K, Sacconi S, Arjomand J, Kinoshita J, Harper SQ. Meeting report: the 2021 FSHD International Research Congress. Skelet Muscle. 2022 01 17; 12(1):1. PMID: 35039091.
      View in: PubMed
    10. Child JR, Chen Q, Reid DW, Jagannathan S, Nicchitta CV. Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules. RNA. 2021 10; 27(10):1241-1256. PMID: 34244458.
      View in: PubMed
    11. Jagannathan S, Ramachandran S, Rissland OS. Slow Down to Catch Up. Cell. 2019 08 08; 178(4):774-776. PMID: 31398334.
      View in: PubMed
    12. Dyle MC, Kolakada D, Cortazar MA, Jagannathan S. How to get away with nonsense: Mechanisms and consequences of escape from nonsense-mediated RNA decay. Wiley Interdiscip Rev RNA. 2020 01; 11(1):e1560. PMID: 31359616.
      View in: PubMed
    13. Jagannathan S, Ogata Y, Gafken PR, Tapscott SJ, Bradley RK. Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy. Elife. 2019 01 15; 8. PMID: 30644821.
      View in: PubMed
    14. Campbell AE, Shadle SC, Jagannathan S, Lim JW, Resnick R, Tawil R, van der Maarel SM, Tapscott SJ. NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins. Elife. 2018 03 13; 7. PMID: 29533181.
      View in: PubMed
    15. Feng Q, Jagannathan S, Bradley RK. The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3?Ubiquitin Ligase Activity. Mol Cell. 2017 Jul 20; 67(2):239-251.e6. PMID: 28669802.
      View in: PubMed
    16. Jagannathan S, Bradley RK. Congenital myotonic dystrophy-an RNA-mediated disease across a developmental continuum. Genes Dev. 2017 06 01; 31(11):1067-1068. PMID: 28717044.
      View in: PubMed
    17. Shadle SC, Zhong JW, Campbell AE, Conerly ML, Jagannathan S, Wong CJ, Morello TD, van der Maarel SM, Tapscott SJ. DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS Genet. 2017 03; 13(3):e1006658. PMID: 28273136.
      View in: PubMed
    18. Jagannathan S, Shadle SC, Resnick R, Snider L, Tawil RN, van der Maarel SM, Bradley RK, Tapscott SJ. Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells. Hum Mol Genet. 2016 10 15; 25(20):4419-4431. PMID: 28171552.
      View in: PubMed
    19. Jagannathan S, Bradley RK. Translational plasticity facilitates the accumulation of nonsense genetic variants in the human population. Genome Res. 2016 12; 26(12):1639-1650. PMID: 27646533.
      View in: PubMed
    20. Feng Q, Snider L, Jagannathan S, Tawil R, van der Maarel SM, Tapscott SJ, Bradley RK. A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy. Elife. 2015 Jan 07; 4. PMID: 25564732.
      View in: PubMed
    21. Jagannathan S, Reid DW, Cox AH, Nicchitta CV. De novo translation initiation on membrane-bound ribosomes as a mechanism for localization of cytosolic protein mRNAs to the endoplasmic reticulum. RNA. 2014 Oct; 20(10):1489-98. PMID: 25142066.
      View in: PubMed
    22. Jagannathan S, Hsu JC, Reid DW, Chen Q, Thompson WJ, Moseley AM, Nicchitta CV. Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum. J Biol Chem. 2014 Sep 12; 289(37):25907-24. PMID: 25063809.
      View in: PubMed
    23. Lacsina JR, Marks OA, Liu X, Reid DW, Jagannathan S, Nicchitta CV. Premature translational termination products are rapidly degraded substrates for MHC class I presentation. PLoS One. 2012; 7(12):e51968. PMID: 23251665.
      View in: PubMed
    24. Chen Q, Jagannathan S, Reid DW, Zheng T, Nicchitta CV. Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells. Mol Biol Cell. 2011 Jul 15; 22(14):2646-58. PMID: 21613539.
      View in: PubMed
    25. Jagannathan S, Nwosu C, Nicchitta CV. Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation. Methods Mol Biol. 2011; 714:301-21. PMID: 21431749.
      View in: PubMed
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