 DNA Ligases
"DNA Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Poly(deoxyribonucleotide):poly(deoxyribonucleotide)ligases. Enzymes that catalyze the joining of preformed deoxyribonucleotides in phosphodiester linkage during genetic processes during repair of a single-stranded break in duplex DNA. The class includes both EC 6.5.1.1 (ATP) and EC 6.5.1.2 (NAD).
| Descriptor ID |
D011088
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| MeSH Number(s) |
D08.811.074.500 D08.811.464.754.600
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| Concept/Terms |
DNA Ligases- DNA Ligases
- Ligases, DNA
- Polydeoxyribonucleotide Ligases
- Ligases, Polydeoxyribonucleotide
- Polydeoxyribonucleotide Synthetases
- Synthetases, Polydeoxyribonucleotide
- DNA Joinases
- Joinases, DNA
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Below are MeSH descriptors whose meaning is more general than "DNA Ligases".
Below are MeSH descriptors whose meaning is more specific than "DNA Ligases".
This graph shows the total number of publications written about "DNA Ligases" by people in this website by year, and whether "DNA Ligases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 2 | 0 | 2 | | 2018 | 2 | 1 | 3 |
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Below are the most recent publications written about "DNA Ligases" by people in Profiles.
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Potapov V, Ong JL, Kucera RB, Langhorst BW, Bilotti K, Pryor JM, Cantor EJ, Canton B, Knight TF, Evans TC, Lohman GJS. Comprehensive Profiling of Four Base Overhang Ligation Fidelity by T4 DNA Ligase and Application to DNA Assembly. ACS Synth Biol. 2018 11 16; 7(11):2665-2674.
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Potapov V, Ong JL, Langhorst BW, Bilotti K, Cahoon D, Canton B, Knight TF, Evans TC, Lohman GJS. A single-molecule sequencing assay for the comprehensive profiling of T4 DNA ligase fidelity and bias during DNA end-joining. Nucleic Acids Res. 2018 07 27; 46(13):e79.
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Sridhar BV, Janczy JR, Hatlevik ?, Wolfson G, Anseth KS, Tibbitt MW. Thermal Stabilization of Biologics with Photoresponsive Hydrogels. Biomacromolecules. 2018 03 12; 19(3):740-747.
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Bauer RJ, Zhelkovsky A, Bilotti K, Crowell LE, Evans TC, McReynolds LA, Lohman GJS. Comparative analysis of the end-joining activity of several DNA ligases. PLoS One. 2017; 12(12):e0190062.
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Bauer RJ, Jurkiw TJ, Evans TC, Lohman GJ. Rapid Time Scale Analysis of T4 DNA Ligase-DNA Binding. Biochemistry. 2017 02 28; 56(8):1117-1129.
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Bauer RJ, Evans TC, Lohman GJ. The Inhibitory Effect of Non-Substrate and Substrate DNA on the Ligation and Self-Adenylylation Reactions Catalyzed by T4 DNA Ligase. PLoS One. 2016; 11(3):e0150802.
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Lohman GJ, Bauer RJ, Nichols NM, Mazzola L, Bybee J, Rivizzigno D, Cantin E, Evans TC. A high-throughput assay for the comprehensive profiling of DNA ligase fidelity. Nucleic Acids Res. 2016 Jan 29; 44(2):e14.
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Lohman GJ, Zhang Y, Zhelkovsky AM, Cantor EJ, Evans TC. Efficient DNA ligation in DNA-RNA hybrid helices by Chlorella virus DNA ligase. Nucleic Acids Res. 2014 Feb; 42(3):1831-44.
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Kwok CK, Ding Y, Sherlock ME, Assmann SM, Bevilacqua PC. A hybridization-based approach for quantitative and low-bias single-stranded DNA ligation. Anal Biochem. 2013 Apr 15; 435(2):181-6.
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Lohman GJS, Chen L, Evans TC. Kinetic characterization of single strand break ligation in duplex DNA by T4 DNA ligase. J Biol Chem. 2011 Dec 23; 286(51):44187-44196.
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