 Steroid 12-alpha-Hydroxylase
"Steroid 12-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.
| Descriptor ID |
D013253
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| MeSH Number(s) |
D08.244.453.900.500 D08.244.453.915.730 D08.811.682.690.708.170.900.500 D08.811.682.690.708.170.915.730 D12.776.422.220.453.900.500 D12.776.422.220.453.915.730
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| Concept/Terms |
Steroid 12-alpha-Hydroxylase- Steroid 12-alpha-Hydroxylase
- Steroid 12 alpha Hydroxylase
- Steroid 12-Monooxygenase
- Steroid 12-Hydroxylase
- Steroid-12-Hydroxylase
- Steroid 12 Hydroxylase
- CYP8B1
- Sterol 12 alpha-Hydroxylase
- 12 alpha-Hydroxylase, Sterol
- Sterol 12 alpha Hydroxylase
- alpha-Hydroxylase, Sterol 12
- Sterol 12-alpha-Hydroxylase
- 12-alpha-Hydroxylase
- 12 alpha Hydroxylase
- 12alpha-Hydroxylase
- 12alpha Hydroxylase
- Cytochrome P450 8B1
- Steroid-12-Monooxygenase
- Steroid 12 Monooxygenase
- Cytochrome P450 CYP8B1
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Below are MeSH descriptors whose meaning is more general than "Steroid 12-alpha-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Steroid 12-alpha-Hydroxylase".
This graph shows the total number of publications written about "Steroid 12-alpha-Hydroxylase" by people in this website by year, and whether "Steroid 12-alpha-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Steroid 12-alpha-Hydroxylase" by people in Profiles.
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Xu G, Li H, Pan LX, Shang Q, Honda A, Ananthanarayanan M, Erickson SK, Shneider BL, Shefer S, Bollineni J, Forman BM, Matsuzaki Y, Suchy FJ, Tint GS, Salen G. FXR-mediated down-regulation of CYP7A1 dominates LXRalpha in long-term cholesterol-fed NZW rabbits. J Lipid Res. 2003 Oct; 44(10):1956-62.
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Xu G, Pan LX, Erickson SK, Forman BM, Shneider BL, Ananthanarayanan M, Li X, Shefer S, Balasubramanian N, Ma L, Asaoka H, Lear SR, Nguyen LB, Dussault I, Suchy FJ, Tint GS, Salen G. Removal of the bile acid pool upregulates cholesterol 7alpha-hydroxylase by deactivating FXR in rabbits. J Lipid Res. 2002 Jan; 43(1):45-50.
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