Steroid 11-beta-Hydroxylase
"Steroid 11-beta-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
| Descriptor ID |
D013252
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| MeSH Number(s) |
D08.244.453.484.750 D08.244.453.915.750 D08.811.682.690.708.170.425.750 D08.811.682.690.708.170.915.750 D12.776.422.220.453.484.750 D12.776.422.220.453.915.750
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| Concept/Terms |
Steroid 11-beta-Hydroxylase- Steroid 11-beta-Hydroxylase
- Steroid 11 beta Hydroxylase
- Cytochrome P-450(11 beta)
- Steroid 11 Hydroxylase
- Steroid-11-Hydroxylase
- Cytochrome P-450 CYP11B1
- Cytochrome P 450 CYP11B1
- CYP11B1
- Steroid 11-beta-Monooxygenase
- Steroid 11 beta Monooxygenase
- CYP 11B1
- Cytochrome P450 11B1
- 11 beta-Hydroxylase
- 11 beta Hydroxylase
- Steroid 11-Hydroxylase
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Below are MeSH descriptors whose meaning is more general than "Steroid 11-beta-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Steroid 11-beta-Hydroxylase".
This graph shows the total number of publications written about "Steroid 11-beta-Hydroxylase" by people in this website by year, and whether "Steroid 11-beta-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Steroid 11-beta-Hydroxylase" by people in Profiles.
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Germano A, Saba L, De Francia S, Rapa I, Perotti P, Berruti A, Volante M, Terzolo M. CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells. PLoS One. 2018; 13(5):e0196931.
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Reyland ME. Protein kinase C is a tonic negative regulator of steroidogenesis and steroid hydroxylase gene expression in Y1 adrenal cells and functions independently of protein kinase A. Mol Endocrinol. 1993 Aug; 7(8):1021-30.
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Reyland ME, Williams DL. Suppression of cAMP-mediated signal transduction in mouse adrenocortical cells which express apolipoprotein E. J Biol Chem. 1991 Nov 05; 266(31):21099-104.