 Steroid 21-Hydroxylase
"Steroid 21-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
| Descriptor ID |
D013255
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| MeSH Number(s) |
D08.244.453.493.500 D08.244.453.915.760 D08.811.682.690.708.170.463.500 D08.811.682.690.708.170.915.760 D12.776.422.220.453.493.500 D12.776.422.220.453.915.760
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| Concept/Terms |
Steroid 21-Hydroxylase- Steroid 21-Hydroxylase
- Cytochrome P-450 21-Hydroxylase
- Cytochrome P 450 21 Hydroxylase
- Cytochrome P-450(c-21)
- Progesterone 21-Hydroxylase
- Progesterone 21 Hydroxylase
- Cytochrome P-450 CYP21
- Cytochrome P 450 CYP21
- Steroid 21-Monooxygenase
- Steroid 21 Monooxygenase
- Cytochrome P450c21
- Cytochrome P-450 c21
- Cytochrome P 450 c21
- P-450 c21, Cytochrome
- 21-Hydroxylase
- 21 Hydroxylase
- Steroid-21-Hydroxylase
- Steroid 21 Hydroxylase
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Below are MeSH descriptors whose meaning is more general than "Steroid 21-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Steroid 21-Hydroxylase".
This graph shows the total number of publications written about "Steroid 21-Hydroxylase" by people in this website by year, and whether "Steroid 21-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2004 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Steroid 21-Hydroxylase" by people in Profiles.
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Ross IL, Babu S, Armstrong T, Zhang L, Schatz D, Pugliese A, Eisenbarth G, Baker Ii P. HLA similarities indicate shared genetic risk in 21-hydroxylase autoantibody positive South African and United States Addison's disease. Tissue Antigens. 2014 Oct; 84(4):361-9.
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Baker P, Fain P, Kahles H, Yu L, Hutton J, Wenzlau J, Rewers M, Badenhoop K, Eisenbarth G. Genetic determinants of 21-hydroxylase autoantibodies amongst patients of the Type 1 Diabetes Genetics Consortium. J Clin Endocrinol Metab. 2012 Aug; 97(8):E1573-8.
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Baker PR, Nanduri P, Gottlieb PA, Yu L, Klingensmith GJ, Eisenbarth GS, Barker JM. Predicting the onset of Addison's disease: ACTH, renin, cortisol and 21-hydroxylase autoantibodies. Clin Endocrinol (Oxf). 2012 May; 76(5):617-24.
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Baker PR, Baschal EE, Fain PR, Nanduri P, Triolo TM, Siebert JC, Armstrong TK, Babu SR, Rewers MJ, Gottlieb PA, Barker JM, Eisenbarth GS. Dominant suppression of Addison's disease associated with HLA-B15. J Clin Endocrinol Metab. 2011 Jul; 96(7):2154-62.
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Triolo TM, Baschal EE, Armstrong TK, Toews CS, Fain PR, Rewers MJ, Yu L, Miao D, Eisenbarth GS, Gottlieb PA, Barker JM. Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes. J Clin Endocrinol Metab. 2009 Nov; 94(11):4517-23.
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Park Y, Kim S, Park S, Kim T, Yu L, Rewers M, Eisenbarth GS. Differential expression of nonislet autoimmunity: comparison of Korean and U.S. patients with type 1 diabetes. Ann N Y Acad Sci. 2004 Dec; 1037:69-73.
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Barker JM, Ide A, Hostetler C, Yu L, Miao D, Fain PR, Eisenbarth GS, Gottlieb PA. Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk population. J Clin Endocrinol Metab. 2005 Jan; 90(1):128-34.
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Li HY, Dahir KM, Blevins LS. Treatment of adult patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a clinical practice audit. Endocr Pract. 2003 Sep-Oct; 9(5):347-52.
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Creighton S, Ransley P, Duffy P, Wilcox D, Mushtaq I, Cuckow P, Woodhouse C, Minto C, Crouch N, Stanhope R, Hughes I, Dattani M, Hindmarsh P, Brain C, Achermann J, Conway G, Liao LM, Barnicoat A, Perry L. Regarding the consensus statement on 21-hydroxylase deficiency from the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology. J Clin Endocrinol Metab. 2003 Jul; 88(7):3455; author reply 3456.
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Yu L, Brewer KW, Gates S, Wu A, Wang T, Babu SR, Gottlieb PA, Freed BM, Noble J, Erlich HA, Rewers MJ, Eisenbarth GS. DRB1*04 and DQ alleles: expression of 21-hydroxylase autoantibodies and risk of progression to Addison's disease. J Clin Endocrinol Metab. 1999 Jan; 84(1):328-35.
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