 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
"25-Hydroxyvitamin D3 1-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
| Descriptor ID |
D015090
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| MeSH Number(s) |
D08.244.453.499.500 D08.244.453.915.400 D08.811.682.690.708.170.493.500 D08.811.682.690.708.170.915.400 D12.776.422.220.453.499.500 D12.776.422.220.453.915.400
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| Concept/Terms |
25-Hydroxyvitamin D3 1-alpha-Hydroxylase- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
- 25 Hydroxyvitamin D3 1 alpha Hydroxylase
- 25-Hydroxycholecalciferol 1-Hydroxylase
- Calcidiol 1-Monooxygenase
- Calcidiol 1 Monooxygenase
- 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
- 25-Hydroxyvitamin D 1-alpha-Hydroxylase
- 1-alpha-Hydroxylase, 25-Hydroxyvitamin D
- 25 Hydroxyvitamin D 1 alpha Hydroxylase
- CYP27B1
- Cytochrome P-450 CYP27B1
- Cytochrome P 450 CYP27B1
- 25-Hydroxyergocalciferol 1-alpha-Hydroxylase
- 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol
- 25 Hydroxyergocalciferol 1 alpha Hydroxylase
- 25-Hydroxycholecalciferol-1-Hydroxylase
- 25 Hydroxycholecalciferol 1 Hydroxylase
- 25-Hydroxyvitamin D2 1-hydroxylase
- 1-hydroxylase, 25-Hydroxyvitamin D2
- 25 Hydroxyvitamin D2 1 hydroxylase
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Below are MeSH descriptors whose meaning is more general than "25-Hydroxyvitamin D3 1-alpha-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "25-Hydroxyvitamin D3 1-alpha-Hydroxylase".
This graph shows the total number of publications written about "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" by people in this website by year, and whether "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2008 | 0 | 1 | 1 | | 2010 | 0 | 2 | 2 | | 2013 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 1 | 2 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" by people in Profiles.
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Torkko K, Till C, Tangen CM, Goodman PJ, Song X, Schenk JM, Lucia MS, Peters U, van Bokhoven A, Thompson IM, Neuhouser ML. Vitamin D Pathway and Other Related Polymorphisms and Risk of Prostate Cancer: Results from the Prostate Cancer Prevention Trial. Cancer Prev Res (Phila). 2020 06; 13(6):521-530.
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Zalewski A, Ma NS, Legeza B, Renthal N, Fl?ck CE, Pandey AV. Vitamin D-Dependent Rickets Type 1 Caused by Mutations in CYP27B1 Affecting Protein Interactions With Adrenodoxin. J Clin Endocrinol Metab. 2016 09; 101(9):3409-18.
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Young KA, Munroe ME, Guthridge JM, Kamen DL, Niewold TB, Gilkeson GS, Weisman MH, Ishimori ML, Kelly J, Gaffney PM, Sivils KH, Lu R, Wallace DJ, Karp DR, Harley JB, James JA, Norris JM. Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus. Ann Rheum Dis. 2017 Jan; 76(1):153-158.
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Mandell E, Seedorf GJ, Ryan S, Gien J, Cramer SD, Abman SH. Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1a-hydroxylase expression in the developing rat. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 01; 309(9):L1018-26.
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O'Brien KO, Li S, Cao C, Kent T, Young BV, Queenan RA, Pressman EK, Cooper EM. Placental CYP27B1 and CYP24A1 expression in human placental tissue and their association with maternal and neonatal calcitropic hormones. J Clin Endocrinol Metab. 2014 Apr; 99(4):1348-56.
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Chen W, Roncal-Jimenez C, Lanaspa M, Gerard S, Chonchol M, Johnson RJ, Jalal D. Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo. Metabolism. 2014 Jan; 63(1):150-60.
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Jablonski KL, Chonchol M, Pierce GL, Walker AE, Seals DR. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension. 2011 Jan; 57(1):63-9.
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Sharma V, Fretwell D, Crees Z, Kerege A, Klopper JP. Thyroid cancer resistance to vitamin D receptor activation is associated with 24-hydroxylase levels but not the ff FokI polymorphism. Thyroid. 2010 Oct; 20(10):1103-11.
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Ahn J, Albanes D, Berndt SI, Peters U, Chatterjee N, Freedman ND, Abnet CC, Huang WY, Kibel AS, Crawford ED, Weinstein SJ, Chanock SJ, Schatzkin A, Hayes RB. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. Carcinogenesis. 2009 May; 30(5):769-76.
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Engelman CD, Fingerlin TE, Langefeld CD, Hicks PJ, Rich SS, Wagenknecht LE, Bowden DW, Norris JM. Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab. 2008 Sep; 93(9):3381-8.
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