 TRPC6 Cation Channel
"TRPC6 Cation Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.
| Descriptor ID |
D000074287
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| MeSH Number(s) |
D12.776.157.530.400.150.850 D12.776.157.530.400.901.500.500 D12.776.543.550.450.150.900 D12.776.543.585.400.150.850 D12.776.543.585.400.901.500.500
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| Concept/Terms |
TRPC6 Cation Channel- TRPC6 Cation Channel
- Cation Channel, TRPC6
- Channel, TRPC6 Cation
- Transient Receptor Potential Cation Channel Subfamily C, Member 6
- TRPC6
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Below are MeSH descriptors whose meaning is more general than "TRPC6 Cation Channel".
Below are MeSH descriptors whose meaning is more specific than "TRPC6 Cation Channel".
This graph shows the total number of publications written about "TRPC6 Cation Channel" by people in this website by year, and whether "TRPC6 Cation Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "TRPC6 Cation Channel" by people in Profiles.
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Hofmann K, Fiedler S, Vierkotten S, Weber J, Klee S, Jia J, Zwickenpflug W, Flockerzi V, Storch U, Yildirim A?, Gudermann T, K?nigshoff M, Dietrich A. Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis. Biochim Biophys Acta Mol Basis Dis. 2017 02; 1863(2):560-568.
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Gonzales AL, Yang Y, Sullivan MN, Sanders L, Dabertrand F, Hill-Eubanks DC, Nelson MT, Earley S. A PLC?1-dependent, force-sensitive signaling network in the myogenic constriction of cerebral arteries. Sci Signal. 2014 May 27; 7(327):ra49.
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Chung D, Kim YS, Phillips JN, Ulloa A, Ku CY, Galan HL, Sanborn BM. Attenuation of canonical transient receptor potential-like channel 6 expression specifically reduces the diacylglycerol-mediated increase in intracellular calcium in human myometrial cells. Endocrinology. 2010 Jan; 151(1):406-16.
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