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Kurt G Beam Jr.

TitleDistinguished Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHYS General Operations
Phone303/724-4542

    Collapse Research 
    Collapse research activities and funding
    R01AR070298     (BEAM, KURT G)Jul 1, 2016 - Jun 30, 2021
    NIH
    Regulation of Membrane Excitability
    Role: Principal Investigator
    R01GM109888     (TAMKUN, MICHAEL M.)Jul 1, 2014 - May 31, 2019
    NIH
    Structural and Functional Interactions within the Neuronal ER/PM Junction
    Role: Co-Principal Investigator
    R13AR057240     (BEAM, KURT G)Apr 1, 2009 - Oct 31, 2009
    NIH
    2009 GRC Muscle: Excitation/Contraction Coupling
    Role: Principal Investigator
    R01AR055104     (BEAM, KURT G)Sep 5, 2008 - Jun 30, 2014
    NIH
    Regulation of Membrane Excitability
    Role: Principal Investigator
    R01NS026416     (BEAM, KURT G)Jul 1, 1988 - Jun 30, 1996
    NIH
    ONTOGENY OF NEURONAL ION CHANNELS
    Role: Principal Investigator
    K04NS001190     (BEAM, KURT G)Dec 1, 1986 - Nov 30, 1989
    NIH
    PHYSIOLOGICAL CONTROL OF CELLULAR EXCITABILITY
    Role: Principal Investigator
    R01NS024444     (BEAM, KURT G)May 1, 1986 - Jul 31, 2007
    NIH
    Regulation of Membrane Excitability
    Role: Principal Investigator
    K04NS000840     (BEAM, KURT G)Apr 1, 1984 - Mar 31, 1986
    NIH
    PHYSIOLOGICAL CONTROL OF CELLULAR EXCITABILITY
    Role: Principal Investigator
    R01NS014901     (BEAM, KURT G)Jan 1, 1979 - Apr 30, 1986
    NIH
    REGULATION OF MEMBRANE EXCITABILITY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Feng W, Lopez JR, Antrobus S, Zheng J, Uryash A, Dong Y, Beqollari D, Bannister RA, Hopkins PM, Beam KG, Allen PD, Pessah IN. Putative malignant hyperthermia mutation CaV1.1-R174W is insufficient to trigger a fulminant response to halothane or confer heat stress intolerance. J Biol Chem. 2023 08; 299(8):104992. PMID: 37392848.
      View in: PubMed
    2. Peters CH, Rickert C, Morotti S, Grandi E, Aronow KA, Beam KG, Proenza C. The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells. J Gen Physiol. 2022 12 05; 154(12). PMID: 36305844.
      View in: PubMed
    3. Dayal A, Perni S, Franzini-Armstrong C, Beam KG, Grabner M. The distal C terminus of the dihydropyridine receptor ?1a subunit is essential for tetrad formation in skeletal muscle. Proc Natl Acad Sci U S A. 2022 05 10; 119(19):e2201136119. PMID: 35507876.
      View in: PubMed
    4. Perni S, Beam K. Junctophilins 1, 2, and 3 all support voltage-induced Ca2+ release despite considerable divergence. J Gen Physiol. 2022 09 05; 154(9). PMID: 35089322.
      View in: PubMed
    5. Perni S, Beam K. Neuronal junctophilins recruit specific CaV and RyR isoforms to ER-PM junctions and functionally alter CaV2.1 and CaV2.2. Elife. 2021 03 26; 10. PMID: 33769283.
      View in: PubMed
    6. Polster A, Dittmer PJ, Perni S, Bichraoui H, Sather WA, Beam KG. Stac Proteins Suppress Ca2+-Dependent Inactivation of Neuronal l-type Ca2+ Channels. J Neurosci. 2018 10 24; 38(43):9215-9227. PMID: 30201773.
      View in: PubMed
    7. Polster A, Nelson BR, Papadopoulos S, Olson EN, Beam KG. Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of CaV1.1. J Gen Physiol. 2018 04 02; 150(4):613-624. PMID: 29467163.
      View in: PubMed
    8. Polster A, Perni S, Filipova D, Moua O, Ohrtman JD, Bichraoui H, Beam KG, Papadopoulos S. Junctional trafficking and restoration of retrograde signaling by the cytoplasmic RyR1 domain. J Gen Physiol. 2018 02 05; 150(2):293-306. PMID: 29284662.
      View in: PubMed
    9. Perni S, Lavorato M, Beam KG. De novo reconstitution reveals the proteins required for skeletal muscle voltage-induced Ca2+ release. Proc Natl Acad Sci U S A. 2017 12 26; 114(52):13822-13827. PMID: 29229815.
      View in: PubMed
    10. Polster A, Nelson BR, Olson EN, Beam KG. Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):10986-91. PMID: 27621462.
      View in: PubMed
    11. Bannister RA, Sheridan DC, Beam KG. Distinct Components of Retrograde Ca(V)1.1-RyR1 Coupling Revealed by a Lethal Mutation in RyR1. Biophys J. 2016 Feb 23; 110(4):912-21. PMID: 26910427.
      View in: PubMed
    12. Ohrtman JD, Romberg CF, Moua O, Bannister RA, Levinson SR, Beam KG. Apparent lack of physical or functional interaction between CaV1.1 and its distal C terminus. J Gen Physiol. 2015 Apr; 145(4):303-14. PMID: 25779869.
      View in: PubMed
    13. Polster A, Perni S, Bichraoui H, Beam KG. Stac adaptor proteins regulate trafficking and function of muscle and neuronal L-type Ca2+ channels. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):602-6. PMID: 25548159.
      View in: PubMed
    14. Bannister RA, Beam KG. Impaired gating of an L-Type Ca(2+) channel carrying a mutation linked to malignant hyperthermia. Biophys J. 2013 May 07; 104(9):1917-22. PMID: 23663834.
      View in: PubMed
    15. Szpyt J, Lorenzon N, Perez CF, Norris E, Allen PD, Beam KG, Sams? M. Three-dimensional localization of the a and ? subunits and of the II-III loop in the skeletal muscle L-type Ca2+ channel. J Biol Chem. 2012 Dec 21; 287(52):43853-61. PMID: 23118233.
      View in: PubMed
    16. Polster A, Ohrtman JD, Beam KG, Papadopoulos S. Fluorescence resonance energy transfer (FRET) indicates that association with the type I ryanodine receptor (RyR1) causes reorientation of multiple cytoplasmic domains of the dihydropyridine receptor (DHPR) a(1S) subunit. J Biol Chem. 2012 Nov 30; 287(49):41560-8. PMID: 23071115.
      View in: PubMed
    17. Bannister RA, Beam KG. Ca(V)1.1: The atypical prototypical voltage-gated Ca?? channel. Biochim Biophys Acta. 2013 Jul; 1828(7):1587-97. PMID: 22982493.
      View in: PubMed
    18. Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos GC, Schebb NH, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14158-63. PMID: 22891308.
      View in: PubMed
    19. Eltit JM, Bannister RA, Moua O, Altamirano F, Hopkins PM, Pessah IN, Molinski TF, L?pez JR, Beam KG, Allen PD. Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7923-8. PMID: 22547813.
      View in: PubMed
    20. Sheridan DC, Moua O, Lorenzon NM, Beam KG. Bimolecular fluorescence complementation and targeted biotinylation provide insight into the topology of the skeletal muscle Ca ( 2+) channel ?1a subunit. Channels (Austin). 2012 Jan-Feb; 6(1):26-40. PMID: 22522946.
      View in: PubMed
    21. Bannister RA, Beam KG. Properties of Na+ currents conducted by a skeletal muscle L-type Ca2+ channel pore mutant (SkEIIIK). Channels (Austin). 2011 May-Jun; 5(3):262-8. PMID: 21406961.
      View in: PubMed
    22. Beam KG, Bannister RA. Looking for answers to EC coupling's persistent questions. J Gen Physiol. 2010 Jul; 136(1):7-12. PMID: 20584887.
      View in: PubMed
    23. Bannister RA, Est?ve E, Eltit JM, Pessah IN, Allen PD, L?pez JR, Beam KG. A malignant hyperthermia-inducing mutation in RYR1 (R163C): consequent alterations in the functional properties of DHPR channels. J Gen Physiol. 2010 Jun; 135(6):629-40. PMID: 20479108.
      View in: PubMed
    24. Est?ve E, Eltit JM, Bannister RA, Liu K, Pessah IN, Beam KG, Allen PD, L?pez JR. A malignant hyperthermia-inducing mutation in RYR1 (R163C): alterations in Ca2+ entry, release, and retrograde signaling to the DHPR. J Gen Physiol. 2010 Jun; 135(6):619-28. PMID: 20479110.
      View in: PubMed
    25. Bannister RA, Beam KG. Ryanodine modification of RyR1 retrogradely affects L-type Ca(2+) channel gating in skeletal muscle. J Muscle Res Cell Motil. 2009; 30(5-6):217-23. PMID: 19802526.
      View in: PubMed
    26. Bannister RA, Beam KG. The cardiac alpha(1C) subunit can support excitation-triggered Ca2+ entry in dysgenic and dyspedic myotubes. Channels (Austin). 2009 Jul-Aug; 3(4):268-73. PMID: 19625771.
      View in: PubMed
    27. Bannister RA, Papadopoulos S, Haarmann CS, Beam KG. Effects of inserting fluorescent proteins into the alpha1S II-III loop: insights into excitation-contraction coupling. J Gen Physiol. 2009 Jul; 134(1):35-51. PMID: 19564426.
      View in: PubMed
    28. Bannister RA, Pessah IN, Beam KG. The skeletal L-type Ca(2+) current is a major contributor to excitation-coupled Ca(2+) entry. J Gen Physiol. 2009 Jan; 133(1):79-91. PMID: 19114636.
      View in: PubMed
    29. Ohrtman J, Ritter B, Polster A, Beam KG, Papadopoulos S. Sequence differences in the IQ motifs of CaV1.1 and CaV1.2 strongly impact calmodulin binding and calcium-dependent inactivation. J Biol Chem. 2008 Oct 24; 283(43):29301-11. PMID: 18718913.
      View in: PubMed
    30. Bannister RA, Grabner M, Beam KG. The alpha(1S) III-IV loop influences 1,4-dihydropyridine receptor gating but is not directly involved in excitation-contraction coupling interactions with the type 1 ryanodine receptor. J Biol Chem. 2008 Aug 22; 283(34):23217-23. PMID: 18556650.
      View in: PubMed
    31. Lorenzon NM, Beam KG. Disease causing mutations of calcium channels. Channels (Austin). 2008 May-Jun; 2(3):163-79. PMID: 18836296.
      View in: PubMed
    32. Bannister RA, Colecraft HM, Beam KG. Rem inhibits skeletal muscle EC coupling by reducing the number of functional L-type Ca2+ channels. Biophys J. 2008 Apr 01; 94(7):2631-8. PMID: 18192376.
      View in: PubMed
    33. Gach MP, Cherednichenko G, Haarmann C, Lopez JR, Beam KG, Pessah IN, Franzini-Armstrong C, Allen PD. Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubes. Biophys J. 2008 Apr 15; 94(8):3023-34. PMID: 18192372.
      View in: PubMed
    34. Lorenzon NM, Beam KG. Accessibility of targeted DHPR sites to streptavidin and functional effects of binding on EC coupling. J Gen Physiol. 2007 Oct; 130(4):379-88. PMID: 17893191.
      View in: PubMed
    35. Sheridan DC, Takekura H, Franzini-Armstrong C, Beam KG, Allen PD, Perez CF. Bidirectional signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19760-5. PMID: 17172444.
      View in: PubMed
    36. Leuranguer V, Papadopoulos S, Beam KG. Organization of calcium channel beta1a subunits in triad junctions in skeletal muscle. J Biol Chem. 2006 Feb 10; 281(6):3521-7. PMID: 16317008.
      View in: PubMed
    37. Bannister RA, Beam KG. The alpha1S N-terminus is not essential for bi-directional coupling with RyR1. Biochem Biophys Res Commun. 2005 Oct 14; 336(1):134-41. PMID: 16139246.
      View in: PubMed
    38. Hurne AM, O'Brien JJ, Wingrove D, Cherednichenko G, Allen PD, Beam KG, Pessah IN. Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic reticulum store depletion. J Biol Chem. 2005 Nov 04; 280(44):36994-7004. PMID: 16120606.
      View in: PubMed
    39. Cherednichenko G, Hurne AM, Fessenden JD, Lee EH, Allen PD, Beam KG, Pessah IN. Conformational activation of Ca2+ entry by depolarization of skeletal myotubes. Proc Natl Acad Sci U S A. 2004 Nov 02; 101(44):15793-8. PMID: 15505226.
      View in: PubMed
    40. Lorenzon NM, Haarmann CS, Norris EE, Papadopoulos S, Beam KG. Metabolic biotinylation as a probe of supramolecular structure of the triad junction in skeletal muscle. J Biol Chem. 2004 Oct 15; 279(42):44057-64. PMID: 15280388.
      View in: PubMed
    41. Papadopoulos S, Leuranguer V, Bannister RA, Beam KG. Mapping sites of potential proximity between the dihydropyridine receptor and RyR1 in muscle using a cyan fluorescent protein-yellow fluorescent protein tandem as a fluorescence resonance energy transfer probe. J Biol Chem. 2004 Oct 15; 279(42):44046-56. PMID: 15280389.
      View in: PubMed
    42. Leuranguer V, Dirksen RT, Beam KG. Potentiated L-type Ca2+ channels rectify. J Gen Physiol. 2003 Jun; 121(6):541-50. PMID: 12743165.
      View in: PubMed
    43. Wilkens CM, Beam KG. Insertion of alpha1S II-III loop and C terminal sequences into alpha1H fails to restore excitation-contraction coupling in dysgenic myotubes. J Muscle Res Cell Motil. 2003; 24(1):99-109. PMID: 12953840.
      View in: PubMed
    44. Protasi F, Paolini C, Nakai J, Beam KG, Franzini-Armstrong C, Allen PD. Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscle. Biophys J. 2002 Dec; 83(6):3230-44. PMID: 12496092.
      View in: PubMed
    45. Proenza C, O'Brien J, Nakai J, Mukherjee S, Allen PD, Beam KG. Identification of a region of RyR1 that participates in allosteric coupling with the alpha(1S) (Ca(V)1.1) II-III loop. J Biol Chem. 2002 Feb 22; 277(8):6530-5. PMID: 11726651.
      View in: PubMed
    46. Wilkens CM, Grabner M, Beam KG. Potentiation of the cardiac L-type Ca(2+) channel (alpha(1C)) by dihydropyridine agonist and strong depolarization occur via distinct mechanisms. J Gen Physiol. 2001 Nov; 118(5):495-508. PMID: 11696608.
      View in: PubMed
    47. Wilkens CM, Kasielke N, Flucher BE, Beam KG, Grabner M. Excitation-contraction coupling is unaffected by drastic alteration of the sequence surrounding residues L720-L764 of the alpha 1S II-III loop. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5892-7. PMID: 11320225.
      View in: PubMed
    48. Lorenzon NM, Grabner M, Suda N, Beam KG. Structure and targeting of RyR1: implications from fusion of green fluorescent protein at the amino-terminal. Arch Biochem Biophys. 2001 Apr 01; 388(1):13-7. PMID: 11361129.
      View in: PubMed
    49. Proenza C, Wilkens CM, Beam KG. Excitation-contraction coupling is not affected by scrambled sequence in residues 681-690 of the dihydropyridine receptor II-III loop. J Biol Chem. 2000 Sep 29; 275(39):29935-7. PMID: 10915779.
      View in: PubMed
    50. Proenza C, Wilkens C, Lorenzon NM, Beam KG. A carboxyl-terminal region important for the expression and targeting of the skeletal muscle dihydropyridine receptor. J Biol Chem. 2000 Jul 28; 275(30):23169-74. PMID: 10801875.
      View in: PubMed
    51. Suda N, Dirksen RT, Gonzalez A, Beam KG. Low serum promotes maturation of excitation-contraction coupling in myotubes. Pflugers Arch. 2000 Mar; 439(5):555-8. PMID: 10764214.
      View in: PubMed
    52. Lorenzon NM, Beam KG. Calcium channelopathies. Kidney Int. 2000 Mar; 57(3):794-802. PMID: 10720931.
      View in: PubMed
    53. Pan F, Beam KG. The absence of resurgent sodium current in mouse spinal neurons. Brain Res. 1999 Dec 04; 849(1-2):162-8. PMID: 10592298.
      View in: PubMed
    54. Dirksen RT, Beam KG. Role of calcium permeation in dihydropyridine receptor function. Insights into channel gating and excitation-contraction coupling. J Gen Physiol. 1999 Sep; 114(3):393-403. PMID: 10469729.
      View in: PubMed
    55. Grabner M, Dirksen RT, Suda N, Beam KG. The II-III loop of the skeletal muscle dihydropyridine receptor is responsible for the Bi-directional coupling with the ryanodine receptor. J Biol Chem. 1999 Jul 30; 274(31):21913-9. PMID: 10419512.
      View in: PubMed
    56. Beam K. Calcium channel splicing: mind your Ps and Qs. Nat Neurosci. 1999 May; 2(5):393-4. PMID: 10321237.
      View in: PubMed
    57. Nakai J, Tanabe T, Konno T, Adams B, Beam KG. Localization in the II-III loop of the dihydropyridine receptor of a sequence critical for excitation-contraction coupling. J Biol Chem. 1998 Sep 25; 273(39):24983-6. PMID: 9737952.
      View in: PubMed
    58. Garc?a KD, Sprunger LK, Meisler MH, Beam KG. The sodium channel Scn8a is the major contributor to the postnatal developmental increase of sodium current density in spinal motoneurons. J Neurosci. 1998 Jul 15; 18(14):5234-9. PMID: 9651206.
      View in: PubMed
    59. Lorenzon NM, Lutz CM, Frankel WN, Beam KG. Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner. J Neurosci. 1998 Jun 15; 18(12):4482-9. PMID: 9614225.
      View in: PubMed
    60. Nakai J, Sekiguchi N, Rando TA, Allen PD, Beam KG. Two regions of the ryanodine receptor involved in coupling with L-type Ca2+ channels. J Biol Chem. 1998 May 29; 273(22):13403-6. PMID: 9593671.
      View in: PubMed
    61. Grabner M, Dirksen RT, Beam KG. Tagging with green fluorescent protein reveals a distinct subcellular distribution of L-type and non-L-type Ca2+ channels expressed in dysgenic myotubes. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1903-8. PMID: 9465115.
      View in: PubMed
    62. Dirksen RT, Nakai J, Gonzalez A, Imoto K, Beam KG. The S5-S6 linker of repeat I is a critical determinant of L-type Ca2+ channel conductance. Biophys J. 1997 Sep; 73(3):1402-9. PMID: 9284307.
      View in: PubMed
    63. Garc?a J, Nakai J, Imoto K, Beam KG. Role of S4 segments and the leucine heptad motif in the activation of an L-type calcium channel. Biophys J. 1997 Jun; 72(6):2515-23. PMID: 9168028.
      View in: PubMed
    64. Nakai J, Ogura T, Protasi F, Franzini-Armstrong C, Allen PD, Beam KG. Functional nonequality of the cardiac and skeletal ryanodine receptors. Proc Natl Acad Sci U S A. 1997 Feb 04; 94(3):1019-22. PMID: 9023375.
      View in: PubMed
    65. Beam KG, Franzini-Armstrong C. Functional and structural approaches to the study of excitation-contraction coupling. Methods Cell Biol. 1997; 52:283-306. PMID: 9379955.
      View in: PubMed
    66. Garc?a KD, Mynlieff M, Sanders DB, Beam KG, Walrond JP. Lambert-Eaton sera reduce low-voltage and high-voltage activated Ca2+ currents in murine dorsal root ganglion neurons. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):9264-9. PMID: 8799189.
      View in: PubMed
    67. Garc?a KD, Beam KG. Reduction of calcium currents by Lambert-Eaton syndrome sera: motoneurons are preferentially affected, and L-type currents are spared. J Neurosci. 1996 Aug 15; 16(16):4903-13. PMID: 8756422.
      View in: PubMed
    68. Adams BA, Tanabe T, Beam KG. Ca2+ current activation rate correlates with alpha 1 subunit density. Biophys J. 1996 Jul; 71(1):156-62. PMID: 8804599.
      View in: PubMed
    69. Dirksen RT, Beam KG. Unitary behavior of skeletal, cardiac, and chimeric L-type Ca2+ channels expressed in dysgenic myotubes. J Gen Physiol. 1996 Jun; 107(6):731-42. PMID: 8783073.
      View in: PubMed
    70. Gallant EM, Balog EM, Beam KG. Slow calcium current is not reduced in malignant hyperthermic porcine myotubes. Muscle Nerve. 1996 Apr; 19(4):450-5. PMID: 8622723.
      View in: PubMed
    71. Nakai J, Dirksen RT, Nguyen HT, Pessah IN, Beam KG, Allen PD. Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor. Nature. 1996 Mar 07; 380(6569):72-5. PMID: 8598910.
      View in: PubMed
    72. Dirksen RT, Beam KG. Single calcium channel behavior in native skeletal muscle. J Gen Physiol. 1995 Feb; 105(2):227-47. PMID: 7539048.
      View in: PubMed
    73. Garc?a J, Beam KG. Calcium transients associated with the T type calcium current in myotubes. J Gen Physiol. 1994 Dec; 104(6):1113-28. PMID: 7699366.
      View in: PubMed
    74. Adams BA, Mori Y, Kim MS, Tanabe T, Beam KG. Heterologous expression of BI Ca2+ channels in dysgenic skeletal muscle. J Gen Physiol. 1994 Nov; 104(5):985-96. PMID: 7876830.
      View in: PubMed
    75. Takekura H, Bennett L, Tanabe T, Beam KG, Franzini-Armstrong C. Restoration of junctional tetrads in dysgenic myotubes by dihydropyridine receptor cDNA. Biophys J. 1994 Aug; 67(2):793-803. PMID: 7948692.
      View in: PubMed
    76. Mynlieff M, Beam KG. Adenosine acting at an A1 receptor decreases N-type calcium current in mouse motoneurons. J Neurosci. 1994 Jun; 14(6):3628-34. PMID: 8207477.
      View in: PubMed
    77. Nakai J, Adams BA, Imoto K, Beam KG. Critical roles of the S3 segment and S3-S4 linker of repeat I in activation of L-type calcium channels. Proc Natl Acad Sci U S A. 1994 Feb 01; 91(3):1014-8. PMID: 8302825.
      View in: PubMed
    78. Garc?a J, Beam KG. Measurement of calcium transients and slow calcium current in myotubes. J Gen Physiol. 1994 Jan; 103(1):107-23. PMID: 8169594.
      View in: PubMed
    79. Garc?a J, Tanabe T, Beam KG. Relationship of calcium transients to calcium currents and charge movements in myotubes expressing skeletal and cardiac dihydropyridine receptors. J Gen Physiol. 1994 Jan; 103(1):125-47. PMID: 8169595.
      View in: PubMed
    80. Tanabe T, Mikami A, Niidome T, Numa S, Adams BA, Beam KG. Structure and function of voltage-dependent calcium channels from muscle. Ann N Y Acad Sci. 1993 Dec 20; 707:81-6. PMID: 9137544.
      View in: PubMed
    81. Mori Y, Niidome T, Fujita Y, Mynlieff M, Dirksen RT, Beam KG, Iwabe N, Miyata T, Furutama D, Furuichi T, et al. Molecular diversity of voltage-dependent calcium channel. Ann N Y Acad Sci. 1993 Dec 20; 707:87-108. PMID: 9137545.
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    82. Chaudhari N, Beam KG. mRNA for cardiac calcium channel is expressed during development of skeletal muscle. Dev Biol. 1993 Feb; 155(2):507-15. PMID: 8381753.
      View in: PubMed
    83. Beam KG, Adams BA, Niidome T, Numa S, Tanabe T. Function of a truncated dihydropyridine receptor as both voltage sensor and calcium channel. Nature. 1992 Nov 12; 360(6400):169-71. PMID: 1331811.
      View in: PubMed
    84. Mynlieff M, Beam KG. Developmental expression of voltage-dependent calcium currents in identified mouse motoneurons. Dev Biol. 1992 Aug; 152(2):407-10. PMID: 1322848.
      View in: PubMed
    85. Mynlieff M, Beam KG. Characterization of voltage-dependent calcium currents in mouse motoneurons. J Neurophysiol. 1992 Jul; 68(1):85-92. PMID: 1325548.
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    86. Tanabe T, Adams BA, Numa S, Beam KG. Repeat I of the dihydropyridine receptor is critical in determining calcium channel activation kinetics. Nature. 1991 Aug 29; 352(6338):800-3. PMID: 1652692.
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    87. McCobb DP, Beam KG. Action potential waveform voltage-clamp commands reveal striking differences in calcium entry via low and high voltage-activated calcium channels. Neuron. 1991 Jul; 7(1):119-27. PMID: 1648936.
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    88. Adams BA, Beam KG. Contractions of dysgenic skeletal muscle triggered by a potentiated, endogenous calcium current. J Gen Physiol. 1991 Apr; 97(4):687-96. PMID: 1711572.
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    89. McCobb DP, Best PM, Beam KG. The differentiation of excitability in embryonic chick limb motoneurons. J Neurosci. 1990 Sep; 10(9):2974-84. PMID: 2168941.
      View in: PubMed
    90. Adams BA, Tanabe T, Mikami A, Numa S, Beam KG. Intramembrane charge movement restored in dysgenic skeletal muscle by injection of dihydropyridine receptor cDNAs. Nature. 1990 Aug 09; 346(6284):569-72. PMID: 2165571.
      View in: PubMed
    91. Tanabe T, Beam KG, Adams BA, Niidome T, Numa S. Regions of the skeletal muscle dihydropyridine receptor critical for excitation-contraction coupling. Nature. 1990 Aug 09; 346(6284):567-9. PMID: 2165570.
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    92. Adams BA, Beam KG. Muscular dysgenesis in mice: a model system for studying excitation-contraction coupling. FASEB J. 1990 Jul; 4(10):2809-16. PMID: 2165014.
      View in: PubMed
    93. Tanabe T, Mikami A, Numa S, Beam KG. Cardiac-type excitation-contraction coupling in dysgenic skeletal muscle injected with cardiac dihydropyridine receptor cDNA. Nature. 1990 Mar 29; 344(6265):451-3. PMID: 2157159.
      View in: PubMed
    94. Chaudhari N, Beam KG. Fibroblasts fuse with myotubes developing in culture. Adv Exp Med Biol. 1990; 280:131-6; discussion 136-7. PMID: 2248133.
      View in: PubMed
    95. Numa S, Tanabe T, Takeshima H, Mikami A, Niidome T, Nishimura S, Adams BA, Beam KG. Molecular insights into excitation-contraction coupling. Cold Spring Harb Symp Quant Biol. 1990; 55:1-7. PMID: 1966760.
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    96. Chaudhari N, Delay R, Beam KG. Restoration of normal function in genetically defective myotubes by spontaneous fusion with fibroblasts. Nature. 1989 Oct 05; 341(6241):445-7. PMID: 2507925.
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    97. Adams BA, Beam KG. A novel calcium current in dysgenic skeletal muscle. J Gen Physiol. 1989 Sep; 94(3):429-44. PMID: 2558151.
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    98. Chaudhari N, Beam KG. The muscular dysgenesis mutation in mice leads to arrest of the genetic program for muscle differentiation. Dev Biol. 1989 Jun; 133(2):456-67. PMID: 2731637.
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    99. McCobb DP, Best PM, Beam KG. Development alters the expression of calcium currents in chick limb motoneurons. Neuron. 1989 Jun; 2(6):1633-43. PMID: 2560650.
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    100. Courbin P, Koenig J, Ressouches A, Beam KG, Powell JA. Rescue of excitation-contraction coupling in dysgenic muscle by addition of fibroblasts in vitro. Neuron. 1989 Apr; 2(4):1341-50. PMID: 2560638.
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    101. Knudson CM, Chaudhari N, Sharp AH, Powell JA, Beam KG, Campbell KP. Specific absence of the alpha 1 subunit of the dihydropyridine receptor in mice with muscular dysgenesis. J Biol Chem. 1989 Jan 25; 264(3):1345-8. PMID: 2536362.
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    102. Beam KG, Tanabe T, Numa S. Structure, function, and regulation of the skeletal muscle dihydropyridine receptor. Ann N Y Acad Sci. 1989; 560:127-37. PMID: 2545129.
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    103. Tanabe T, Beam KG, Powell JA, Numa S. Restoration of excitation-contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA. Nature. 1988 Nov 10; 336(6195):134-9. PMID: 2903448.
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    104. Kinnamon SC, Dionne VE, Beam KG. Apical localization of K+ channels in taste cells provides the basis for sour taste transduction. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):7023-7. PMID: 2457924.
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    105. Beam KG. Duchenne muscular dystrophy. Localizing the gene product. Nature. 1988 Jun 30; 333(6176):798-9. PMID: 3290681.
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    106. Beam KG, Knudson CM. Effect of postnatal development on calcium currents and slow charge movement in mammalian skeletal muscle. J Gen Physiol. 1988 Jun; 91(6):799-815. PMID: 2458430.
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    107. Beam KG, Knudson CM. Calcium currents in embryonic and neonatal mammalian skeletal muscle. J Gen Physiol. 1988 Jun; 91(6):781-98. PMID: 2458429.
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    108. Caldwell JH, Campbell DT, Beam KG. Na channel distribution in vertebrate skeletal muscle. J Gen Physiol. 1986 Jun; 87(6):907-32. PMID: 2425042.
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    109. Beam KG, Knudson CM, Powell JA. A lethal mutation in mice eliminates the slow calcium current in skeletal muscle cells. Nature. 1986 Mar 13-19; 320(6058):168-70. PMID: 2419767.
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    110. Beam KG, Caldwell JH, Campbell DT. Na channels in skeletal muscle concentrated near the neuromuscular junction. Nature. 1985 Feb 14-20; 313(6003):588-90. PMID: 2578630.
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    111. Simon BJ, Beam KG. Slow charge movement in mammalian skeletal muscle. J Gen Physiol. 1985 Jan; 85(1):1-19. PMID: 3968530.
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    112. Simon BJ, Beam KG. The influence of transverse tubular delays on the kinetics of charge movement in mammalian skeletal muscle. J Gen Physiol. 1985 Jan; 85(1):21-42. PMID: 3968532.
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    113. Donaldson PL, Beam KG. Calcium currents in a fast-twitch skeletal muscle of the rat. J Gen Physiol. 1983 Oct; 82(4):449-68. PMID: 6315856.
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    114. Beam KG, Donaldson PL. A quantitative study of potassium channel kinetics in rat skeletal muscle from 1 to 37 degrees C. J Gen Physiol. 1983 Apr; 81(4):485-512. PMID: 6304231.
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    115. Beam KG, Donaldson PL. Slow components of potassium tail currents in rat skeletal muscle. J Gen Physiol. 1983 Apr; 81(4):513-30. PMID: 6304232.
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    116. Simon BJ, Beam KG. Charge movement in a fast twitch skeletal muscle from rat. Biophys J. 1983 Feb; 41(2):223-6. PMID: 6838965.
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    117. Nestler EJ, Beam KG, Greengard P. Nicotinic cholinergic stimulation increases cyclic GMP levels in vertebrate skeletal muscle. Nature. 1978 Oct 05; 275(5679):451-3. PMID: 211436.
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    118. Beam KG, Nestler EJ, Greengard P. Increased cyclic GMP levels associated with contraction in muscle fibres of the giant barnacle. Nature. 1977 Jun 09; 267(5611):534-6. PMID: 195221.
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    119. Beam KG. A voltage-clamp study of the effect of two lidocaine derivatives on the time course of end-plate currents. J Physiol. 1976 Jun; 258(2):279-300. PMID: 1085354.
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