 Inositol 1,4,5-Trisphosphate Receptors
"Inositol 1,4,5-Trisphosphate Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular receptors that bind to INOSITOL 1,4,5-TRISPHOSPHATE and play an important role in its intracellular signaling. Inositol 1,4,5-trisphosphate receptors are calcium channels that release CALCIUM in response to increased levels of inositol 1,4,5-trisphosphate in the CYTOPLASM.
| Descriptor ID |
D053496
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| MeSH Number(s) |
D12.776.157.530.400.150.760 D12.776.543.550.450.150.760 D12.776.543.585.400.150.760 D12.776.826.179
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| Concept/Terms |
Inositol 1,4,5-Trisphosphate Receptors- Inositol 1,4,5-Trisphosphate Receptors
- INSP3 Receptor
- Receptor, INSP3
- IP3 Receptor
- Receptor, IP3
- Inositol 1,4,5-Triphosphate Receptors
- Receptor, Inositol-1,4,5-triphosphate
- Inositol-1,4,5-Triphosphate Receptor
- 1,4,5-INTP Receptor
- Inositol Triphosphate Receptor
- Receptor, Inositol Triphosphate
- Triphosphate Receptor, Inositol
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Below are MeSH descriptors whose meaning is more general than "Inositol 1,4,5-Trisphosphate Receptors".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Membrane Transport Proteins [D12.776.157.530]
- Ion Channels [D12.776.157.530.400]
- Calcium Channels [D12.776.157.530.400.150]
- Inositol 1,4,5-Trisphosphate Receptors [D12.776.157.530.400.150.760]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Ion Channels [D12.776.543.550.450]
- Calcium Channels [D12.776.543.550.450.150]
- Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.550.450.150.760]
- Membrane Transport Proteins [D12.776.543.585]
- Ion Channels [D12.776.543.585.400]
- Calcium Channels [D12.776.543.585.400.150]
- Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.585.400.150.760]
- Receptors, Cytoplasmic and Nuclear [D12.776.826]
- Inositol 1,4,5-Trisphosphate Receptors [D12.776.826.179]
Below are MeSH descriptors whose meaning is more specific than "Inositol 1,4,5-Trisphosphate Receptors".
This graph shows the total number of publications written about "Inositol 1,4,5-Trisphosphate Receptors" by people in this website by year, and whether "Inositol 1,4,5-Trisphosphate Receptors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2004 | 0 | 2 | 2 | | 2006 | 0 | 3 | 3 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2012 | 1 | 2 | 3 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2019 | 0 | 2 | 2 | | 2021 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Inositol 1,4,5-Trisphosphate Receptors" by people in Profiles.
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Harris S, Putra M, Gilmore KL, Vora NL. Two unrelated fetuses with ITPR1 missense variants and fetal hydrops. Prenat Diagn. 2023 10; 43(11):1463-1466.
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Kremer KN, Buser A, Thumkeo D, Narumiya S, Jacobelli J, Pelanda R, Torres RM. LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2118816119.
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Szczesniak LM, Bonzerato CG, Schulman JJ, Bah A, Wojcikiewicz RJH. Bok binds to a largely disordered loop in the coupling domain of type 1 inositol 1,4,5-trisphosphate receptor. Biochem Biophys Res Commun. 2021 05 14; 553:180-186.
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Mendez JM, Kolora LD, Lemon JS, Dupree SL, Keestra-Gounder AM. Activation of the Endoplasmic Reticulum Stress Response Impacts the NOD1 Signaling Pathway. Infect Immun. 2019 08; 87(8).
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Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE, Yule DI, Wojcikiewicz RJH. Bok regulates mitochondrial fusion and morphology. Cell Death Differ. 2019 12; 26(12):2682-2694.
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Fees CP, Stith BJ. Insemination or phosphatidic acid induces an outwardly spiraling disk of elevated Ca2+ to produce the Ca2+ wave during Xenopus laevis fertilization. Dev Biol. 2019 04 01; 448(1):59-68.
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Schulman JJ, Wright FA, Han X, Zluhan EJ, Szczesniak LM, Wojcikiewicz RJ. The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate Receptors. J Biol Chem. 2016 May 27; 291(22):11820-8.
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Wang Q, Wang Y, Downey GP, Plotnikov S, McCulloch CA. A ternary complex comprising FAK, PTPa and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts. Biochem J. 2016 Feb 15; 473(4):397-410.
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Gonzales AL, Yang Y, Sullivan MN, Sanders L, Dabertrand F, Hill-Eubanks DC, Nelson MT, Earley S. A PLC?1-dependent, force-sensitive signaling network in the myogenic constriction of cerebral arteries. Sci Signal. 2014 May 27; 7(327):ra49.
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Orabi AI, Luo Y, Ahmad MU, Shah AU, Mannan Z, Wang D, Sarwar S, Muili KA, Shugrue C, Kolodecik TR, Singh VP, Lowe ME, Thrower E, Chen J, Husain SZ. IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules. PLoS One. 2012; 7(11):e48465.
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