 Iron Regulatory Protein 1
"Iron Regulatory Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
| Descriptor ID |
D035941
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| MeSH Number(s) |
D08.811.520.241.300.050.500 D12.776.157.427.374.375.960 D12.776.157.725.374 D12.776.494.500 D12.776.556.579.374.375.960 D12.776.664.962.374
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| Concept/Terms |
Iron Regulatory Protein 1- Iron Regulatory Protein 1
- IRP-1 Protein
- IRP 1 Protein
- IRP1 Protein
- ACO1 Protein
- Aconitase 1, Soluble
- Soluble Aconitase 1
- IRE-BP1
- IRE BP1
- Ferritin Repressor Protein
- Repressor Protein, Ferritin
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Below are MeSH descriptors whose meaning is more general than "Iron Regulatory Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Iron Regulatory Protein 1".
This graph shows the total number of publications written about "Iron Regulatory Protein 1" by people in this website by year, and whether "Iron Regulatory Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Iron Regulatory Protein 1" by people in Profiles.
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Kallianpur AR, Jia P, Ellis RJ, Zhao Z, Bloss C, Wen W, Marra CM, Hulgan T, Simpson DM, Morgello S, McArthur JC, Clifford DB, Collier AC, Gelman BB, McCutchan JA, Franklin D, Samuels DC, Rosario D, Holzinger E, Murdock DG, Letendre S, Grant I. Genetic variation in iron metabolism is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy. PLoS One. 2014; 9(8):e103123.
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DeRuisseau KC, Park YM, DeRuisseau LR, Cowley PM, Fazen CH, Doyle RP. Aging-related changes in the iron status of skeletal muscle. Exp Gerontol. 2013 Nov; 48(11):1294-302.
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Ghosh MC, Zhang DL, Jeong SY, Kovtunovych G, Ollivierre-Wilson H, Noguchi A, Tu T, Senecal T, Robinson G, Crooks DR, Tong WH, Ramaswamy K, Singh A, Graham BB, Tuder RM, Yu ZX, Eckhaus M, Lee J, Springer DA, Rouault TA. Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2a. Cell Metab. 2013 Feb 05; 17(2):271-81.
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