 Ferrochelatase
"Ferrochelatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
| Descriptor ID |
D005294
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| MeSH Number(s) |
D08.811.520.500 D12.776.157.427.374.375.957 D12.776.556.579.374.375.617 D12.776.575.562
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| Concept/Terms |
Ferrochelatase- Ferrochelatase
- Protoheme Ferro-Lyase
- Ferro-Lyase, Protoheme
- Protoheme Ferro Lyase
- Heme Synthetase
- Synthetase, Heme
- Porphyrin-Metal Chelatase
- Chelatase, Porphyrin-Metal
- Porphyrin Metal Chelatase
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Below are MeSH descriptors whose meaning is more general than "Ferrochelatase".
Below are MeSH descriptors whose meaning is more specific than "Ferrochelatase".
This graph shows the total number of publications written about "Ferrochelatase" by people in this website by year, and whether "Ferrochelatase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ferrochelatase" by people in Profiles.
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Botto NC, Shpall RL, Kim J, Bruckner AL. A young girl with weather-beaten, waxy knuckles. J Pediatr. 2010 Apr; 156(4):671-4.
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Hon T, Dodd A, Dirmeier R, Gorman N, Sinclair PR, Zhang L, Poyton RO. A mechanism of oxygen sensing in yeast. Multiple oxygen-responsive steps in the heme biosynthetic pathway affect Hap1 activity. J Biol Chem. 2003 Dec 12; 278(50):50771-80.
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