 Multigene Family
"Multigene Family" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
| Descriptor ID |
D005810
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| MeSH Number(s) |
G05.360.340.024.340.645
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| Concept/Terms |
Multigene Family- Multigene Family
- Families, Multigene
- Family, Multigene
- Multigene Families
Gene Clusters- Gene Clusters
- Cluster, Gene
- Clusters, Gene
- Gene Cluster
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Below are MeSH descriptors whose meaning is more general than "Multigene Family".
Below are MeSH descriptors whose meaning is more specific than "Multigene Family".
This graph shows the total number of publications written about "Multigene Family" by people in this website by year, and whether "Multigene Family" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 | | 1996 | 0 | 6 | 6 | | 1997 | 2 | 1 | 3 | | 1998 | 0 | 1 | 1 | | 1999 | 1 | 2 | 3 | | 2000 | 1 | 2 | 3 | | 2001 | 1 | 3 | 4 | | 2002 | 2 | 6 | 8 | | 2003 | 2 | 2 | 4 | | 2004 | 0 | 5 | 5 | | 2005 | 5 | 4 | 9 | | 2006 | 2 | 4 | 6 | | 2007 | 3 | 6 | 9 | | 2008 | 2 | 9 | 11 | | 2009 | 2 | 2 | 4 | | 2010 | 1 | 3 | 4 | | 2011 | 3 | 6 | 9 | | 2012 | 2 | 5 | 7 | | 2013 | 5 | 7 | 12 | | 2014 | 2 | 4 | 6 | | 2015 | 2 | 0 | 2 | | 2017 | 2 | 4 | 6 | | 2018 | 4 | 3 | 7 | | 2019 | 1 | 5 | 6 | | 2020 | 0 | 5 | 5 | | 2021 | 1 | 2 | 3 | | 2022 | 1 | 1 | 2 | | 2023 | 0 | 2 | 2 | | 2025 | 0 | 2 | 2 |
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Below are the most recent publications written about "Multigene Family" by people in Profiles.
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Holmes EC, Breunig SL, Johnson CW, Beckham GT, Bleem AC. Insights into genetic determinants of volatile fatty acid catabolism in Cupriavidus necator H16. Appl Environ Microbiol. 2025 Jul 23; 91(7):e0051525.
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Bird KA, Brock JR, Grabowski PP, Harder AM, Healy AL, Shu S, Barry K, Boston L, Daum C, Guo J, Lipzen A, Walstead R, Grimwood J, Schmutz J, Lu C, Comai L, McKay JK, Pires JC, Edger PP, Lovell JT, Kliebenstein DJ. Allopolyploidy expanded gene content but not pangenomic variation in the hexaploid oilseed Camelina sativa. Genetics. 2025 Jan 08; 229(1):1-44.
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Raju RP, Cai L, Tyagi A, Pugazhenthi S. Interactions of Cellular Energetic Gene Clusters in the Alzheimer's Mouse Brain. Mol Neurobiol. 2024 Jan; 61(1):476-486.
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Rhie A, Nurk S, Cechova M, Hoyt SJ, Taylor DJ, Altemose N, Hook PW, Koren S, Rautiainen M, Alexandrov IA, Allen J, Asri M, Bzikadze AV, Chen NC, Chin CS, Diekhans M, Flicek P, Formenti G, Fungtammasan A, Garcia Giron C, Garrison E, Gershman A, Gerton JL, Grady PGS, Guarracino A, Haggerty L, Halabian R, Hansen NF, Harris R, Hartley GA, Harvey WT, Haukness M, Heinz J, Hourlier T, Hubley RM, Hunt SE, Hwang S, Jain M, Kesharwani RK, Lewis AP, Li H, Logsdon GA, Lucas JK, Makalowski W, Markovic C, Martin FJ, Mc Cartney AM, McCoy RC, McDaniel J, McNulty BM, Medvedev P, Mikheenko A, Munson KM, Murphy TD, Olsen HE, Olson ND, Paulin LF, Porubsky D, Potapova T, Ryabov F, Salzberg SL, Sauria MEG, Sedlazeck FJ, Shafin K, Shepelev VA, Shumate A, Storer JM, Surapaneni L, Taravella Oill AM, Thibaud-Nissen F, Timp W, Tomaszkiewicz M, Vollger MR, Walenz BP, Watwood AC, Weissensteiner MH, Wenger AM, Wilson MA, Zarate S, Zhu Y, Zook JM, Eichler EE, O'Neill RJ, Schatz MC, Miga KH, Makova KD, Phillippy AM. The complete sequence of a human Y chromosome. Nature. 2023 09; 621(7978):344-354.
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Egbert S, Hoffman JR, McMullin RT, Lendemer JC, Sorensen JL. Unraveling usnic acid: a comparison of biosynthetic gene clusters between two reindeer lichen (Cladonia rangiferina and C. uncialis). Fungal Biol. 2022 Nov-Dec; 126(11-12):697-706.
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Cheng J, Clayton JS, Acemel RD, Zheng Y, Taylor RL, Keles S, Franke M, Boackle SA, Harley JB, Quail E, Gómez-Skarmeta JL, Ulgiati D. Regulatory Architecture of the RCA Gene Cluster Captures an Intragenic TAD Boundary, CTCF-Mediated Chromatin Looping and a Long-Range Intergenic Enhancer. Front Immunol. 2022; 13:901747.
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Nguyen NA, Cong Y, Hurrell RC, Arias N, Garg N, Puri AW, Schmidt EW, Agarwal V. A Silent Biosynthetic Gene Cluster from a Methanotrophic Bacterium Potentiates Discovery of a Substrate Promiscuous Proteusin Cyclodehydratase. ACS Chem Biol. 2022 06 17; 17(6):1577-1585.
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Yang C, Hallmark B, Chai JC, O'Connor TD, Reynolds LM, Wood AC, Seeds M, Chen YI, Steffen LM, Tsai MY, Kaplan RC, Daviglus ML, Mandarino LJ, Fretts AM, Lemaitre RN, Coletta DK, Blomquist SA, Johnstone LM, Tontsch C, Qi Q, Ruczinski I, Rich SS, Mathias RA, Chilton FH, Manichaikul A. Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations. Commun Biol. 2021 07 28; 4(1):918.
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Nguyen NA, Lin Z, Mohanty I, Garg N, Schmidt EW, Agarwal V. An Obligate Peptidyl Brominase Underlies the Discovery of Highly Distributed Biosynthetic Gene Clusters in Marine Sponge Microbiomes. J Am Chem Soc. 2021 07 14; 143(27):10221-10231.
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Ióca LP, Dai Y, Kunakom S, Diaz-Espinosa J, Krunic A, Crnkovic CM, Orjala J, Sanchez LM, Ferreira AG, Berlinck RGS, Eustáquio AS. A Family of Nonribosomal Peptides Modulate Collective Behavior in Pseudovibrio Bacteria Isolated from Marine Sponges*. Angew Chem Int Ed Engl. 2021 Jul 12; 60(29):15891-15898.
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