 Caspase 1
"Caspase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
| Descriptor ID |
D020170
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| MeSH Number(s) |
D08.811.277.656.262.500.126.550.100 D08.811.277.656.300.200.126.550.100 D12.644.360.075.405.550.100 D12.776.476.075.405.550.100
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| Concept/Terms |
Caspase 1- Caspase 1
- Interleukin-1beta Converting Enzyme
- Converting Enzyme, Interleukin-1beta
- Interleukin 1beta Converting Enzyme
- ICE Protease
- IL1BC Enzyme
- IL-1 beta Convertase
- Convertase, IL-1 beta
- IL 1 beta Convertase
- beta Convertase, IL-1
- CASP1 Caspase
- Caspase, CASP1
- Interleukin-1 Converting Enzyme
- Converting Enzyme, Interleukin-1
- Interleukin 1 Converting Enzyme
- IL-1 beta-Converting Enzyme
- IL 1 beta Converting Enzyme
- beta-Converting Enzyme, IL-1
Procaspase-1- Procaspase-1
- Procaspase 1
- Pro-Caspase-1
- Pro Caspase 1
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Below are MeSH descriptors whose meaning is more general than "Caspase 1".
Below are MeSH descriptors whose meaning is more specific than "Caspase 1".
This graph shows the total number of publications written about "Caspase 1" by people in this website by year, and whether "Caspase 1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1997 | 0 | 2 | 2 | | 1998 | 1 | 2 | 3 | | 1999 | 2 | 2 | 4 | | 2000 | 0 | 1 | 1 | | 2001 | 3 | 2 | 5 | | 2002 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 2 | 3 | | 2005 | 3 | 3 | 6 | | 2006 | 1 | 3 | 4 | | 2007 | 3 | 2 | 5 | | 2008 | 1 | 2 | 3 | | 2009 | 1 | 6 | 7 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 2 | 2 | | 2012 | 0 | 4 | 4 | | 2013 | 1 | 6 | 7 | | 2014 | 3 | 5 | 8 | | 2015 | 1 | 2 | 3 | | 2016 | 0 | 4 | 4 | | 2017 | 0 | 2 | 2 | | 2018 | 0 | 3 | 3 | | 2019 | 1 | 0 | 1 | | 2020 | 0 | 2 | 2 | | 2021 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2024 | 0 | 1 | 1 | | 2025 | 0 | 2 | 2 | | 2026 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Caspase 1" by people in Profiles.
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Lai YH, Liu YH, Chen JY, Lee CT, Wang SY, Chiang-Ni C, Luo YH, Chi CY, Noda T, Lu SL, Tsai YS, Wu JJ, Tsai PJ. Endothelial NLRP3 inflammasome activation drives immunothrombosis in Streptococcus pyogenes infection. Life Sci. 2026 Mar 15; 389:124239.
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Bauernfried S, Komar T, Sterle K, Tanzer MC, Horswill AR, Mann M, Hornung V. Inflammasome-independent IL-1ß activation via staphopain A protease of Staphylococcus aureus. J Biol Chem. 2025 10; 301(10):110574.
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Lippincott MJ, Tomkinson J, Bunten D, Mohammadi M, Kastl J, Knop J, Schwandner R, Huang J, Ongo G, Robichaud N, Dagher M, Mansilla-Soto A, Saravia-Estrada C, Tsuboi M, Basualto-Alarcón C, Way GP. A morphology and secretome map of pyroptosis. Mol Biol Cell. 2025 Jun 01; 36(6):ar63.
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Delesky EA, Lobo AJ, Srubar WV. Measurement of Ice-Binding Protein Activity in Highly Alkaline Environments. Methods Mol Biol. 2024; 2730:135-154.
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Keestra-Gounder AM, Nagao PE. Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation. Front Immunol. 2023; 14:1075834.
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Useinovic N, Maksimovic S, Liechty C, Cabrera OH, Quillinan N, Jevtovic-Todorovic V. Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats. Br J Anaesth. 2022 10; 129(4):555-566.
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Gange WS, Qiao JB, Park PJ, McDonnell JF, Tan Z, Perlman JI, Bu P. Protection of Retinal Function by Nucleoside Reverse Transcriptase Inhibitors Following Retinal Ischemia/Reperfusion Injury. J Ocul Pharmacol Ther. 2021 10; 37(8):485-491.
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Jain S, Plenter R, Jeremy R, Nydam T, Gill RG, Jani A. The impact of Caspase-1 deletion on apoptosis and acute kidney injury in a murine transplant model. Cell Signal. 2021 09; 85:110039.
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Frank MG, Baratta MV, Zhang K, Fallon IP, Pearson MA, Liu G, Hutchinson MR, Watkins LR, Goldys EM, Maier SF. Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1ß protein in dorsal hippocampus. Brain Behav Immun. 2020 11; 90:70-80.
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Liu G, Baird AW, Parsons MJ, Fan K, Skerrett-Byrne DA, Nair PM, Makanyengo S, Chen J, Neal R, Goggins BJ, Tay H, Mathe A, Soh WS, Minahan K, Hansbro PM, Nixon B, McCaughan GW, Holtmann G, Colgan SP, Keely S. Platelet activating factor receptor acts to limit colitis-induced liver inflammation. FASEB J. 2020 06; 34(6):7718-7732.
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