 Sp3 Transcription Factor
"Sp3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A specificity protein transcription factor that contains three C-terminal CYS2-HIS2 ZINC FINGERS. It regulates expression of a variety of genes including VASCULAR ENDOTHELIAL GROWTH FACTOR and CYCLIN-DEPENDENT KINASE INHIBITOR P27.
| Descriptor ID |
D051705
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| MeSH Number(s) |
D12.776.260.522.750.750 D12.776.930.375.750.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Sp3 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Sp3 Transcription Factor".
This graph shows the total number of publications written about "Sp3 Transcription Factor" by people in this website by year, and whether "Sp3 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sp3 Transcription Factor" by people in Profiles.
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Manes TL, Simenauer A, Geohring JL, Flemming J, Brehm M, Cota-Gomez A. The HIV-Tat protein interacts with Sp3 transcription factor and inhibits its binding to a distal site of the sod2 promoter in human pulmonary artery endothelial cells. Free Radic Biol Med. 2020 02 01; 147:102-113.
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Whitten C, Swygert S, Butler SE, Finco TS. Transcription of the LAT gene is regulated by multiple binding sites for Sp1 and Sp3. Gene. 2008 Apr 30; 413(1-2):58-66.
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Xu J, Rogers MB. Modulation of Bone Morphogenetic Protein (BMP) 2 gene expression by Sp1 transcription factors. Gene. 2007 May 01; 392(1-2):221-9.
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Wynes MW, Riches DW. Transcription of macrophage IGF-I exon 1 is positively regulated by the 5'-untranslated region and negatively regulated by the 5'-flanking region. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1089-98.
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Marecki JC, Cota-Gomez A, Vaitaitis GM, Honda JR, Porntadavity S, St Clair DK, Flores SC. HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity. Free Radic Biol Med. 2004 Sep 15; 37(6):869-80.
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Steinke JW, Barekzi E, Hagman J, Borish L. Functional analysis of -571 IL-10 promoter polymorphism reveals a repressor element controlled by sp1. J Immunol. 2004 Sep 01; 173(5):3215-22.
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Maclean KN, Kraus E, Kraus JP. The dominant role of Sp1 in regulating the cystathionine beta-synthase -1a and -1b promoters facilitates potential tissue-specific regulation by Kruppel-like factors. J Biol Chem. 2004 Mar 05; 279(10):8558-66.
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Holmes KW, Hales R, Chu S, Maxwell MJ, Mogayzel PJ, Zeitlin PL. Modulation of Sp1 and Sp3 in lung epithelial cells regulates ClC-2 chloride channel expression. Am J Respir Cell Mol Biol. 2003 Oct; 29(4):499-505.
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Wright RM, Riley MG, Weigel LK, Ginger LA, Costantino DA, McManaman JL. Activation of the human aldehyde oxidase (hAOX1) promoter by tandem cooperative Sp1/Sp3 binding sites: identification of complex architecture in the hAOX upstream DNA that includes a proximal promoter, distal activation sites, and a silencer element. DNA Cell Biol. 2000 Aug; 19(8):459-74.
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