 Cystic Fibrosis Transmembrane Conductance Regulator
"Cystic Fibrosis Transmembrane Conductance Regulator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)
| Descriptor ID |
D019005
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| MeSH Number(s) |
D12.776.157.530.100.304.500 D12.776.157.530.400.175.125 D12.776.157.530.450.074.500.500.500.500 D12.776.543.550.450.175.125 D12.776.543.585.100.304.500 D12.776.543.585.400.175.125 D12.776.543.585.450.074.500.500.500.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cystic Fibrosis Transmembrane Conductance Regulator".
Below are MeSH descriptors whose meaning is more specific than "Cystic Fibrosis Transmembrane Conductance Regulator".
This graph shows the total number of publications written about "Cystic Fibrosis Transmembrane Conductance Regulator" by people in this website by year, and whether "Cystic Fibrosis Transmembrane Conductance Regulator" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 1 | 0 | 1 | | 2000 | 1 | 0 | 1 | | 2001 | 1 | 1 | 2 | | 2002 | 4 | 1 | 5 | | 2003 | 1 | 2 | 3 | | 2004 | 5 | 3 | 8 | | 2005 | 1 | 1 | 2 | | 2006 | 5 | 3 | 8 | | 2007 | 5 | 3 | 8 | | 2008 | 3 | 3 | 6 | | 2009 | 7 | 1 | 8 | | 2010 | 3 | 1 | 4 | | 2011 | 3 | 3 | 6 | | 2012 | 2 | 1 | 3 | | 2013 | 4 | 0 | 4 | | 2014 | 4 | 2 | 6 | | 2015 | 6 | 1 | 7 | | 2016 | 4 | 6 | 10 | | 2017 | 4 | 4 | 8 | | 2018 | 11 | 3 | 14 | | 2019 | 7 | 9 | 16 | | 2020 | 10 | 6 | 16 | | 2021 | 12 | 10 | 22 | | 2022 | 10 | 16 | 26 | | 2023 | 1 | 22 | 23 | | 2024 | 8 | 2 | 10 | | 2025 | 12 | 10 | 22 | | 2026 | 2 | 3 | 5 |
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Below are the most recent publications written about "Cystic Fibrosis Transmembrane Conductance Regulator" by people in Profiles.
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Zemanick ET, Somayaji R. Clearing the Air: Rethinking Airway Infection With CFTR Modulators. J Infect Dis. 2026 04 29; 233(4):628-630.
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Kroes S, Taylor-Cousar JL, Zampoli M, Karadag B, van der Ent CK, de Winter-de Groot KM, Beekman JM, Spelier S. Patient-Derived Intestinal Organoids in the Global Cystic Fibrosis Landscape. Pediatr Pulmonol. 2026 Apr; 61(4):e71584.
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Lee J, Yekula A, Wexler A, Zhuang W, Elangovan A, Rosario J, Burger P, Ramaraju G, Addissie B, Lim N, Narkewicz MR, Twohig P. Decoding liver injury in cystic fibrosis: How to tell drug-induced liver injury from cystic fibrosis liver disease. World J Gastroenterol. 2026 Mar 14; 32(10):114946.
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Metcalf A, Hoppe JE, Martiniano SL, Zaretsky MV, Zemanick ET, Sagel SD. In Utero CFTR Modulator Therapy in Fetuses With Cystic Fibrosis. Neoreviews. 2026 Mar 01; 27(3):e157-e169.
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Zaretsky MV, Blumenfeld YJ, Szentpetery SS, Taylor-Cousar JL. Translating Emerging Data for Fetal Treatment of Cystic Fibrosis. Prenat Diagn. 2026 Mar; 46(3):417-423.
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Knoll RL, Brauny MM, Robert E, Cloos L, Waser L, Hilbert K, Ulmer N, Hillen B, Birkner T, Bartolomaeus TUP, Nitsche O, Jarquín-Díaz VH, Lynch S, Gehring S, Maier L, Poplawska K, Forslund-Startceva SK. CFTR modulator therapy drives microbiome restructuring through improved host physiology in cystic fibrosis: the IMMProveCF phase IV trial. Nat Commun. 2025 Nov 18; 16(1):10111.
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Vladar EK, Gillen AE, Yadav S, Murphree MR, Baraghoshi D, Harris JK, Pruesse E, Niemiec SS, Wilson AW, Hisert KB, Humphries SM, Strand M, Lynch DA, Seibold MA, Beswick DM, Taylor-Cousar JL. Transcriptomic and functional responses of the cystic fibrosis airway epithelium to CFTR modulator therapy. JCI Insight. 2025 Nov 10; 10(21).
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Brown DG, Manke J, Armstrong M, Yadav S, Marentette JO, Roede JR, Vladar EK, Reisdorph N, Phelan VV. Impact of overexpression of wild-type CFTR and elexacaftor-tezacaftor-ivacaftor on oxylipin production by the CFBE41o- bronchial epithelial cell line. Prostaglandins Other Lipid Mediat. 2025 Dec; 181:107043.
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Goryachok M, Fairbanks-Mahnke A, Fulte S, Tamkin E, McCarty A, Larson ED, Planet PJ, Clark SE. Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus. J Cyst Fibros. 2026 Mar; 25(2):340-352.
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Apablaza T, Barros-Poblete M, Delpiano L, Villanueva S, Guequen A, Tapia-Balladares B, Haq I, Tribiños F, Hernández-Rivas S, Verdon B, Biggart MGS, Sánchez Y, Ward C, Baxter BD, Restrepo D, Cornejo I, Tarran R, Catalán MA, Gray MA, Flores CA. Succinate Chemosensing Induces Cystic Fibrosis Transmembrane Conductance Regulator-dependent Airway Clearance that Is Impaired in Cystic Fibrosis. Am J Respir Cell Mol Biol. 2025 Nov; 73(5):769-779.
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