Sonia Flores
Title | Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-MED |
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Research T34GM149812 (ALLEN, RICHARD M)Jun 1, 2023 - May 31, 2028 NIH MARC at the University of Colorado Denver Role: Co-Principal Investigator |
| R25HL146166 (FLORES, SONIA CASTRO)Jan 7, 2019 - Feb 28, 2029 NIH Health AI and Data Science in Cardiovascular and Pulmonary Disease: Application and Bioethics (HARP-BIO) Role: Principal Investigator |
| U01HL121819 (FLORES, SONIA CASTRO)Sep 26, 2013 - Jul 31, 2019 NIH Genotypic and functional properties of HIV-1 Nef clinical isolates in PAH-HIV Role: Principal Investigator |
| T34GM096958 (ALLEN, RICHARD M ;FLORES, SONIA CASTRO)Jun 1, 2013 - May 31, 2024 NIH UC Denver MARC U-STAR Role: Co-Principal Investigator |
| R25HL103286 (FLORES, SONIA CASTRO)Jul 1, 2010 - Jun 30, 2025 NIH GEMS, a Short-Term Summer Internship Program for Diverse Students Role: Principal Investigator |
| R25GM083333 (FLORES, SONIA CASTRO)Mar 1, 2008 - Feb 28, 2013 NIH MBRS-IMSD Program at the University of Colorado at Denver and Health Sciences Cen Role: Principal Investigator |
| R01HL090480 (FLORES, SONIA CASTRO)Sep 28, 2007 - Jun 30, 2014 NIH Longitudinal studies of HIV-1 Nef in Pulmonary Hypertension Role: Principal Investigator |
| R01HL083491 (FLORES, SONIA CASTRO)Sep 29, 2005 - Sep 30, 2013 NIH Pathobiology of HIV(SIV)-Induced Angioproliferative Pul* Role: Principal Investigator |
| T35HL007961 (FLORES, SONIA CASTRO)Jun 1, 2000 - May 31, 2011 NIH Biomedical Research Internship Program for Undergraduate Role: Principal Investigator |
| R01HL059785 (FLORES, SONIA CASTRO)Sep 1, 1997 - Jun 30, 2009 NIH Role of redox status in HIV-1 Tat-mediated inflammation Role: Principal Investigator |
| K14HL003157 (FLORES, SONIA CASTRO)May 13, 1994 - Aug 31, 2000 NIH OXIDATIVE BALANCE IN MODELS OF ACUTE LUNG INJURY Role: Principal Investigator |
| T32HL007171 (STENMARK, KURT R.)Jul 1, 1976 - Jun 30, 2028 NIH Translational Pulmonary Vascular Biology Program Role: Co-Principal Investigator |
Bibliographic
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Burden M, Flores SC, Schwartz DA. COVID-19: A Time to Reinvest in Our Scientists. Am J Respir Crit Care Med. 2021 05 01; 203(9):1190-1191. PMID: 33596390.
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Pino-Jones AD, Cervantes L, Flores S, Jones CD, Keach J, Ngov LK, Schwartz DA, Wierman M, Anstett T, Bowden K, Keniston A, Burden M. Advancing Diversity, Equity, and Inclusion in Hospital Medicine. J Hosp Med. 2021 04; 16(4):198-203. PMID: 33617435.
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Almodovar S, Wade BE, Porter KM, Smith JM, Lopez-Astacio RA, Bijli K, Kang BY, Cribbs SK, Guidot DM, Molehin D, McNair BK, Pumarejo-Gomez L, Perez Hernandez J, Salazar EA, Martinez EG, Huang L, Kessing CF, Suarez-Martinez EB, Pruitt K, Hsue PY, Tyor WR, Flores SC, Sutliff RL. HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension. Sci Rep. 2020 07 16; 10(1):11696. PMID: 32678115.
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Honda JR, Hess T, Carlson R, Kandasamy P, Nieto Ramirez LM, Norton GJ, Virdi R, Islam MN, Mehaffy C, Hasan NA, Epperson LE, Hesser D, Alper S, Strong M, Flores SC, Voelker DR, Dobos KM, Chan ED. Nontuberculous Mycobacteria Show Differential Infectivity and Use Phospholipids to Antagonize LL-37. Am J Respir Cell Mol Biol. 2020 03; 62(3):354-363. PMID: 31545652.
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Almodovar S, Swanson J, Giavedoni LD, Kanthaswamy S, Long CS, Voelkel NF, Edwards MG, Folkvord JM, Connick E, Westmoreland SV, Luciw PA, Flores SC. Lung Vascular Remodeling, Cardiac Hypertrophy, and Inflammatory Cytokines in SHIVnef-Infected Macaques. Viral Immunol. 2018 04; 31(3):206-222. PMID: 29256819.
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Presti RM, Flores SC, Palmer BE, Atkinson JJ, Lesko CR, Lau B, Fontenot AP, Roman J, McDyer JF, Twigg HL. Mechanisms Underlying HIV-Associated Noninfectious Lung Disease. Chest. 2017 11; 152(5):1053-1060. PMID: 28427967.
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Morris A, Flores SC. Study of the Lung Microbiome. Have We Reached the End of the Beginning? Am J Respir Crit Care Med. 2017 01 01; 195(1):15-16. PMID: 28035854.
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Leader JK, Crothers K, Huang L, King MA, Morris A, Thompson BW, Flores SC, Drummond MB, Rom WN, Diaz PT. Risk Factors Associated With Quantitative Evidence of Lung Emphysema and Fibrosis in an HIV-Infected Cohort. J Acquir Immune Defic Syndr. 2016 Apr 01; 71(4):420-7. PMID: 26914911.
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Duncan GA, Lockett A, Villegas LR, Almodovar S, Gomez JL, Flores SC, Wilkes DS, Tigno XT. National Heart, Lung, and Blood Institute Workshop Summary: Enhancing Opportunities for Training and Retention of a Diverse Biomedical Workforce. Ann Am Thorac Soc. 2016 Apr; 13(4):562-7. PMID: 27058184.
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Beck JM, Schloss PD, Venkataraman A, Twigg H, Jablonski KA, Bushman FD, Campbell TB, Charlson ES, Collman RG, Crothers K, Curtis JL, Drews KL, Flores SC, Fontenot AP, Foulkes MA, Frank I, Ghedin E, Huang L, Lynch SV, Morris A, Palmer BE, Schmidt TM, Sodergren E, Weinstock GM, Young VB. Multicenter Comparison of Lung and Oral Microbiomes of HIV-infected and HIV-uninfected Individuals. Am J Respir Crit Care Med. 2015 Dec 01; 192(11):1335-44. PMID: 26247840.
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Honda JR, Hess T, Malcolm KC, Ovrutsky AR, Bai X, Irani VR, Dobos KM, Chan ED, Flores SC. Pathogenic nontuberculous mycobacteria resist and inactivate cathelicidin: implication of a novel role for polar mycobacterial lipids. PLoS One. 2015; 10(5):e0126994. PMID: 25993058.
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Neff CP, Chain JL, MaWhinney S, Martin AK, Linderman DJ, Flores SC, Campbell TB, Palmer BE, Fontenot AP. Lymphocytic alveolitis is associated with the accumulation of functionally impaired HIV-specific T cells in the lung of antiretroviral therapy-naive subjects. Am J Respir Crit Care Med. 2015 Feb 15; 191(4):464-73. PMID: 25536276.
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Honda JR, Connick E, MaWhinney S, Chan ED, Flores SC. Plasma LL-37 correlates with vitamin D and is reduced in human immunodeficiency virus-1 infected individuals not receiving antiretroviral therapy. J Med Microbiol. 2014 Jul; 63(Pt 7):997-1003. PMID: 24821067.
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Wang T, Green LA, Gupta SK, Kim C, Wang L, Almodovar S, Flores SC, Prudovsky IA, Jolicoeur P, Liu Z, Clauss M. Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction. PLoS One. 2014; 9(3):e91063. PMID: 24608713.
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Martin RJ, Flores S, Kraft M. The lung microbiome. A new frontier in pulmonary medicine: introduction and perspective. Ann Am Thorac Soc. 2014 Jan; 11 Suppl 1:S1-2. PMID: 24437397.
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Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Muc5b is required for airway defence. Nature. 2014 Jan 16; 505(7483):412-6. PMID: 24317696.
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Lozupone CA, Li M, Campbell TB, Flores SC, Linderman D, Gebert MJ, Knight R, Fontenot AP, Palmer BE. Alterations in the gut microbiota associated with HIV-1 infection. Cell Host Microbe. 2013 Sep 11; 14(3):329-39. PMID: 24034618.
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Twigg HL, Morris A, Ghedin E, Curtis JL, Huffnagle GB, Crothers K, Campbell TB, Flores SC, Fontenot AP, Beck JM, Huang L, Lynch S, Knox KS, Weinstock G. Use of bronchoalveolar lavage to assess the respiratory microbiome: signal in the noise. Lancet Respir Med. 2013 Jul; 1(5):354-6. PMID: 24429191.
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Morris A, Beck JM, Schloss PD, Campbell TB, Crothers K, Curtis JL, Flores SC, Fontenot AP, Ghedin E, Huang L, Jablonski K, Kleerup E, Lynch SV, Sodergren E, Twigg H, Young VB, Bassis CM, Venkataraman A, Schmidt TM, Weinstock GM. Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med. 2013 May 15; 187(10):1067-75. PMID: 23491408.
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Lozupone C, Cota-Gomez A, Palmer BE, Linderman DJ, Charlson ES, Sodergren E, Mitreva M, Abubucker S, Martin J, Yao G, Campbell TB, Flores SC, Ackerman G, Stombaugh J, Ursell L, Beck JM, Curtis JL, Young VB, Lynch SV, Huang L, Weinstock GM, Knox KS, Twigg H, Morris A, Ghedin E, Bushman FD, Collman RG, Knight R, Fontenot AP. Widespread colonization of the lung by Tropheryma whipplei in HIV infection. Am J Respir Crit Care Med. 2013 May 15; 187(10):1110-7. PMID: 23392441.
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Flores SC, Almodovar S. Human immunodeficiency virus, herpes virus infections, and pulmonary vascular disease. Pulm Circ. 2013 Jan; 3(1):165-70. PMID: 23662195.
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Almodovar S, Knight R, Allshouse AA, Roemer S, Lozupone C, McDonald D, Widmann J, Voelkel NF, Shelton RJ, Suarez EB, Hammer KW, Goujard C, Petrosillo N, Simonneau G, Hsue PY, Humbert M, Flores SC. Human Immunodeficiency Virus nef signature sequences are associated with pulmonary hypertension. AIDS Res Hum Retroviruses. 2012 Jun; 28(6):607-18. PMID: 22066947.
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Honda JR, Shang S, Shanley CA, Caraway ML, Henao-Tamayo M, Chan ED, Basaraba RJ, Orme IM, Ordway DJ, Flores SC. Immune Responses of HIV-1 Tat Transgenic Mice to Mycobacterium Tuberculosis W-Beijing SA161. Open AIDS J. 2011; 5:86-95. PMID: 22046211.
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Cota-Gomez A, Flores AC, Ling XF, Varella-Garcia M, Flores SC. HIV-1 Tat increases oxidant burden in the lungs of transgenic mice. Free Radic Biol Med. 2011 Nov 01; 51(9):1697-707. PMID: 21855628.
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Crothers K, Thompson BW, Burkhardt K, Morris A, Flores SC, Diaz PT, Chaisson RE, Kirk GD, Rom WN, Huang L. HIV-associated lung infections and complications in the era of combination antiretroviral therapy. Proc Am Thorac Soc. 2011 Jun; 8(3):275-81. PMID: 21653528.
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Almodovar S, Hsue PY, Morelli J, Huang L, Flores SC. Pathogenesis of HIV-associated pulmonary hypertension: potential role of HIV-1 Nef. Proc Am Thorac Soc. 2011 Jun; 8(3):308-12. PMID: 21653533.
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Zimmerman MA, Haskins K, Bradley B, Gilman J, Gamboni-Robertson F, Flores SC. Autoimmune-mediated vascular injury occurs prior to sustained hyperglycemia in a murine model of type I diabetes mellitus. J Surg Res. 2011 Jun 15; 168(2):e195-202. PMID: 21470634.
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Lee JE, Patel K, Almod?var S, Tuder RM, Flores SC, Sehgal PB. Dependence of Golgi apparatus integrity on nitric oxide in vascular cells: implications in pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2011 Apr; 300(4):H1141-58. PMID: 21217069.
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Almodovar S, Cicalini S, Petrosillo N, Flores SC. Pulmonary hypertension associated with HIV infection: pulmonary vascular disease: the global perspective. Chest. 2010 Jun; 137(6 Suppl):6S-12S. PMID: 20522575.
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Sehgal PB, Mukhopadhyay S, Patel K, Xu F, Almod?var S, Tuder RM, Flores SC. Golgi dysfunction is a common feature in idiopathic human pulmonary hypertension and vascular lesions in SHIV-nef-infected macaques. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L729-37. PMID: 19648286.
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Hassoun PM, Mouthon L, Barber? JA, Eddahibi S, Flores SC, Grimminger F, Jones PL, Maitland ML, Michelakis ED, Morrell NW, Newman JH, Rabinovitch M, Schermuly R, Stenmark KR, Voelkel NF, Yuan JX, Humbert M. Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol. 2009 Jun 30; 54(1 Suppl):S10-S19. PMID: 19555853.
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Irwin DC, McCord JM, Nozik-Grayck E, Beckly G, Foreman B, Sullivan T, White M, T Crossno J, Bailey D, Flores SC, Majka S, Klemm D, van Patot MC. A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak. Free Radic Biol Med. 2009 Jul 01; 47(1):55-61. PMID: 19358884.
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Voelkel NF, Cool CD, Flores S. From viral infection to pulmonary arterial hypertension: a role for viral proteins? AIDS. 2008 Sep; 22 Suppl 3:S49-53. PMID: 18845922.
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Zimmerman MA, Flores SC. Autoimmune-mediated oxidative stress and endothelial dysfunction: implications of accelerated vascular injury in type I diabetes. J Surg Res. 2009 Jul; 155(1):173-8. PMID: 18805553.
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Nicolls MR, Haskins K, Flores SC. Oxidant stress, immune dysregulation, and vascular function in type I diabetes. Antioxid Redox Signal. 2007 Jul; 9(7):879-89. PMID: 17508913.
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Tuder RM, Marecki JC, Richter A, Fijalkowska I, Flores S. Pathology of pulmonary hypertension. Clin Chest Med. 2007 Mar; 28(1):23-42, vii. PMID: 17338926.
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Marecki JC, Cool CD, Parr JE, Beckey VE, Luciw PA, Tarantal AF, Carville A, Shannon RP, Cota-Gomez A, Tuder RM, Voelkel NF, Flores SC. HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques. Am J Respir Crit Care Med. 2006 Aug 15; 174(4):437-45. PMID: 16728715.
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Marecki J, Cool C, Voelkel N, Luciw P, Flores S. Evidence for vascular remodeling in the lungs of macaques infected with simian immunodeficiency virus/HIV NEF recombinant virus. Chest. 2005 Dec; 128(6 Suppl):621S-622S. PMID: 16373878.
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Ling X, Cota-Gomez A, Flores NC, Hernandez-Saavedra D, McCord JM, Marecki JC, Haskins K, McDuffie M, Powers K, Kench J, Oka M, McMurtry I, Flores SC. Alterations in redox homeostasis and prostaglandins impair endothelial-dependent vasodilation in euglycemic autoimmune nonobese diabetic mice. Free Radic Biol Med. 2005 Oct 15; 39(8):1089-98. PMID: 16198235.
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Porntadavity S, Nath A, Prachayasittikul V, Cota-Gomez A, Flores SC, St Clair DK. Different roles of Sp family members in HIV-1 Tat-mediated manganese superoxide dismutase suppression in hepatocellular carcinoma cells. DNA Cell Biol. 2005 May; 24(5):299-310. PMID: 15869407.
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Hines IN, Harada H, Flores S, Gao B, McCord JM, Grisham MB. Endothelial nitric oxide synthase protects the post-ischemic liver: potential interactions with superoxide. Biomed Pharmacother. 2005 May; 59(4):183-9. PMID: 15862713.
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Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, Bartholomew PJ, Aplin AE, Tai YT, Aguirre-Ghiso J, Flores SC, Melendez JA. Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem. 2005 Apr 29; 280(17):16916-24. PMID: 15701646.
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Stringer KA, Freed BM, Dunn JS, Sayers S, Gustafson DL, Flores SC. Particulate phase cigarette smoke increases MnSOD, NQO1, and CINC-1 in rat lungs. Free Radic Biol Med. 2004 Nov 15; 37(10):1527-33. PMID: 15477004.
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Marecki JC, Cota-Gomez A, Vaitaitis GM, Honda JR, Porntadavity S, St Clair DK, Flores SC. HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity. Free Radic Biol Med. 2004 Sep 15; 37(6):869-80. PMID: 15706661.
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Taniai H, Hines IN, Bharwani S, Maloney RE, Nimura Y, Gao B, Flores SC, McCord JM, Grisham MB, Aw TY. Susceptibility of murine periportal hepatocytes to hypoxia-reoxygenation: role for NO and Kupffer cell-derived oxidants. Hepatology. 2004 Jun; 39(6):1544-52. PMID: 15185295.
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Qadri I, Iwahashi M, Capasso JM, Hopken MW, Flores S, Schaack J, Simon FR. Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1. Biochem J. 2004 Mar 15; 378(Pt 3):919-28. PMID: 14670077.
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Harada H, Hines IN, Flores S, Gao B, McCord J, Scheerens H, Grisham MB. Role of NADPH oxidase-derived superoxide in reduced size liver ischemia and reperfusion injury. Arch Biochem Biophys. 2004 Mar 01; 423(1):103-8. PMID: 14871473.
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Bowers R, Cool C, Murphy RC, Tuder RM, Hopken MW, Flores SC, Voelkel NF. Oxidative stress in severe pulmonary hypertension. Am J Respir Crit Care Med. 2004 Mar 15; 169(6):764-9. PMID: 14701708.
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Haskins K, Bradley B, Powers K, Fadok V, Flores S, Ling X, Pugazhenthi S, Reusch J, Kench J. Oxidative stress in type 1 diabetes. Ann N Y Acad Sci. 2003 Nov; 1005:43-54. PMID: 14679039.
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Gu Y, Xu YC, Wu RF, Nwariaku FE, Souza RF, Flores SC, Terada LS. p47phox participates in activation of RelA in endothelial cells. J Biol Chem. 2003 May 09; 278(19):17210-7. PMID: 12618429.
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Tuder RM, Zhen L, Cho CY, Taraseviciene-Stewart L, Kasahara Y, Salvemini D, Voelkel NF, Flores SC. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):88-97. PMID: 12600822.
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Gao B, Flores SC, Leff JA, Bose SK, McCord JM. Synthesis and anti-inflammatory activity of a chimeric recombinant superoxide dismutase: SOD2/3. Am J Physiol Lung Cell Mol Physiol. 2003 Jun; 284(6):L917-25. PMID: 12736188.
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Piganelli JD, Flores SC, Cruz C, Koepp J, Batinic-Haberle I, Crapo J, Day B, Kachadourian R, Young R, Bradley B, Haskins K. A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes. 2002 Feb; 51(2):347-55. PMID: 11812741.
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Gaubatz JW, Flores SC. Purification of eucaryotic extrachromosomal circular DNAs using exonuclease III. Anal Biochem. 1990 Feb 01; 184(2):305-10. PMID: 2327574.
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Gaubatz JW, Flores SC. Tissue-specific and age-related variations in repetitive sequences of mouse extrachromosomal circular DNAs. Mutat Res. 1990 Jan; 237(1):29-36. PMID: 2320037.
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Flores SC, Sunnerhagen P, Moore TK, Gaubatz JW. Characterization of repetitive sequence families in mouse heart small polydisperse circular DNAs: age-related studies. Nucleic Acids Res. 1988 May 11; 16(9):3889-906. PMID: 3375074.
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Flores SC, Moore TK, Gaubatz JW. Dispersed repetitive sequences of the mouse genome are differentially represented in extrachromosomal circular DNAs in vivo. Plasmid. 1987 May; 17(3):257-60. PMID: 2819911.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2002 | 1 | 2003 | 5 | 2004 | 5 | 2005 | 5 | 2006 | 1 | 2007 | 2 | 2008 | 2 | 2009 | 3 | 2010 | 1 | 2011 | 6 | 2012 | 1 | 2013 | 6 | 2014 | 3 | 2015 | 3 | 2016 | 2 | 2017 | 3 | 2020 | 2 | 2021 | 2 |
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