 Folic Acid Deficiency
"Folic Acid Deficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Descriptor ID |
D005494
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| MeSH Number(s) |
C18.654.521.500.133.699.308
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| Concept/Terms |
Folic Acid Deficiency- Folic Acid Deficiency
- Deficiency, Folic Acid
- Acid Deficiencies, Folic
- Acid Deficiency, Folic
- Deficiencies, Folic Acid
- Folic Acid Deficiencies
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Below are MeSH descriptors whose meaning is more general than "Folic Acid Deficiency".
Below are MeSH descriptors whose meaning is more specific than "Folic Acid Deficiency".
This graph shows the total number of publications written about "Folic Acid Deficiency" by people in this website by year, and whether "Folic Acid Deficiency" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1994 | 3 | 0 | 3 | | 1996 | 0 | 2 | 2 | | 1999 | 1 | 0 | 1 | | 2000 | 1 | 2 | 3 | | 2003 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 1 | 2 | | 2012 | 2 | 1 | 3 | | 2013 | 0 | 2 | 2 | | 2014 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 4 | 0 | 4 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 2 | 0 | 2 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Folic Acid Deficiency" by people in Profiles.
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Goh YE, Manger MS, Duggal M, Das R, Saklani S, Agarwal S, Budhija D, Jamwal M, Singh BL, Dahiya N, Luo H, Long JM, Westcott J, Krebs NF, Gibson RS, Brown KH, McDonald CM. Women in Selected Communities of Punjab, India Have a High Prevalence of Iron, Zinc, Vitamin B12, and Folate Deficiencies: Implications for a Multiply-Fortified Salt Intervention. Nutrients. 2023 Jul 03; 15(13).
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Fiddler JL, Xiu Y, Blum JE, Lamarre SG, Phinney WN, Stabler SP, Brosnan ME, Brosnan JT, Thalacker-Mercer AE, Field MS. Reduced Shmt2 Expression Impairs Mitochondrial Folate Accumulation and Respiration, and Leads to Uracil Accumulation in Mouse Mitochondrial DNA. J Nutr. 2021 10 01; 151(10):2882-2893.
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Higa R, Rosario FJ, Powell TL, Jansson T, Jawerbaum A. Inhibition of MTOR signaling impairs rat embryo organogenesis by affecting folate availability. Reproduction. 2021 04; 161(4):365-373.
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Stabler SP. Alterations in Sulfur Amino Acids as Biomarkers of Disease. J Nutr. 2020 10 01; 150(Suppl 1):2532S-2537S.
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Li H, Wang X, Zhao H, Wang F, Bao Y, Guo J, Chang S, Wu L, Cheng H, Chen S, Zou J, Cui X, Niswander L, Finnell RH, Wang H, Zhang T. Low folate concentration impacts mismatch repair deficiency in neural tube defects. Epigenomics. 2020 01; 12(1):5-18.
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Xiao S, Tang YS, Kusumanchi P, Stabler SP, Zhang Y, Antony AC. Folate Deficiency Facilitates Genomic Integration of Human Papillomavirus Type 16 DNA In Vivo in a Novel Mouse Model for Rapid Oncogenic Transformation of Human Keratinocytes. J Nutr. 2018 03 01; 148(3):389-400.
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Henry CJ, Nemkov T, Cas?s-Selves M, Bilousova G, Zaberezhnyy V, Higa KC, Serkova NJ, Hansen KC, D'Alessandro A, DeGregori J. Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis. Haematologica. 2017 12; 102(12):1985-1994.
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Rosario FJ, Nathanielsz PW, Powell TL, Jansson T. Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice. Sci Rep. 2017 06 21; 7(1):3982.
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Rosario FJ, Powell TL, Jansson T. mTOR folate sensing links folate availability to trophoblast cell function. J Physiol. 2017 07 01; 595(13):4189-4206.
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Tang YS, Khan RA, Xiao S, Hansen DK, Stabler SP, Kusumanchi P, Jayaram HN, Antony AC. Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells. J Nutr. 2017 04; 147(4):482-498.
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