 Choline Deficiency
"Choline Deficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
| Descriptor ID |
D002796
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| MeSH Number(s) |
C18.654.521.500.133.699.160
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| Concept/Terms |
Choline Deficiency- Choline Deficiency
- Deficiency, Choline
- Choline Deficiencies
- Deficiencies, Choline
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Below are MeSH descriptors whose meaning is more general than "Choline Deficiency".
Below are MeSH descriptors whose meaning is more specific than "Choline Deficiency".
This graph shows the total number of publications written about "Choline Deficiency" by people in this website by year, and whether "Choline Deficiency" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 1 | 2 | | 2008 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Choline Deficiency" by people in Profiles.
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Wankhade UD, Zhong Y, Kang P, Alfaro M, Chintapalli SV, Thakali KM, Shankar K. Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. PLoS One. 2017; 12(4):e0175675.
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Beaudin AE, Perry CA, Stabler SP, Allen RH, Stover PJ. Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice. Am J Clin Nutr. 2012 Apr; 95(4):882-91.
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Beaudin AE, Abarinov EV, Malysheva O, Perry CA, Caudill M, Stover PJ. Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. Am J Clin Nutr. 2012 Jan; 95(1):109-14.
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Beaudin AE, Abarinov EV, Noden DM, Perry CA, Chu S, Stabler SP, Allen RH, Stover PJ. Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. Am J Clin Nutr. 2011 Apr; 93(4):789-98.
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Stevens KE, Adams CE, Mellott TJ, Robbins E, Kisley MA. Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. Brain Res. 2008 Oct 27; 1237:84-90.
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Fischer LM, daCosta KA, Kwock L, Stewart PW, Lu TS, Stabler SP, Allen RH, Zeisel SH. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr. 2007 May; 85(5):1275-85.
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Rahman SM, Schroeder-Gloeckler JM, Janssen RC, Jiang H, Qadri I, Maclean KN, Friedman JE. CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis. Hepatology. 2007 May; 45(5):1108-17.
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Selhub J, Seyoum E, Pomfret EA, Zeisel SH. Effects of choline deficiency and methotrexate treatment upon liver folate content and distribution. Cancer Res. 1991 Jan 01; 51(1):16-21.
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Zeisel SH, Zola T, daCosta KA, Pomfret EA. Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver. Biochem J. 1989 May 01; 259(3):725-9.
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Zeisel SH, Ellis AL, Sun XF, Pomfret EA, Ting BT, Janghorbani M. Dose-response relations in urinary excretion of trimethylselenonium in the rat. J Nutr. 1987 Sep; 117(9):1609-14.
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