 Protein Engineering
"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
| Descriptor ID |
D015202
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| MeSH Number(s) |
E05.393.420.601
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| Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
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Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 | | 1996 | 0 | 2 | 2 | | 1997 | 0 | 2 | 2 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 1 | 0 | 1 | | 2004 | 3 | 0 | 3 | | 2005 | 1 | 1 | 2 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 3 | 3 | | 2008 | 4 | 2 | 6 | | 2009 | 2 | 2 | 4 | | 2010 | 0 | 3 | 3 | | 2011 | 2 | 3 | 5 | | 2013 | 0 | 1 | 1 | | 2014 | 2 | 3 | 5 | | 2015 | 2 | 1 | 3 | | 2016 | 6 | 2 | 8 | | 2017 | 2 | 2 | 4 | | 2018 | 4 | 2 | 6 | | 2019 | 5 | 1 | 6 | | 2020 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 2 | 3 | | 2023 | 0 | 1 | 1 | | 2024 | 2 | 4 | 6 |
To return to the timeline, click here.
Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Baumer ZT, Newton MS, L?fstrand L, Carpio Paucar GN, Farny NG, Whitehead TA. Engineered Stop and Go T7 RNA Polymerases. ACS Synth Biol. 2024 12 20; 13(12):4165-4174.
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Leonard AC, Friedman AJ, Chayer R, Petersen BM, Woojuh J, Xing Z, Cutler SR, Kaar JL, Shirts MR, Whitehead TA. Rationalizing Diverse Binding Mechanisms to the Same Protein Fold: Insights for Ligand Recognition and Biosensor Design. ACS Chem Biol. 2024 08 16; 19(8):1757-1772.
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Norton-Baker B, Denton MCR, Murphy NP, Fram B, Lim S, Erickson E, Gauthier NP, Beckham GT. Enabling high-throughput enzyme discovery and engineering with a low-cost, robot-assisted pipeline. Sci Rep. 2024 06 24; 14(1):14449.
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Petersen BM, Kirby MB, Chrispens KM, Irvin OM, Strawn IK, Haas CM, Walker AM, Baumer ZT, Ulmer SA, Ayala E, Rhodes ER, Guthmiller JJ, Steiner PJ, Whitehead TA. An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries. Nat Commun. 2024 May 10; 15(1):3974.
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Daffern N, Johansson KE, Baumer ZT, Robertson NR, Woojuh J, Bedewitz MA, Davis Z, Wheeldon I, Cutler SR, Lindorff-Larsen K, Whitehead TA. GMMA Can Stabilize Proteins Across Different Functional Constraints. J Mol Biol. 2024 Jun 01; 436(11):168586.
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Brunecky R, Knott BC, Subramanian V, Linger JG, Beckham GT, Amore A, Taylor LE, Vander Wall TA, Lunin VV, Zheng F, Garrido M, Schuster L, Fulk EM, Farmer S, Himmel ME, Decker SR. Engineering of glycoside hydrolase family 7 cellobiohydrolases directed by natural diversity screening. J Biol Chem. 2024 03; 300(3):105749.
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Daffern N, Francino-Urdaniz IM, Baumer ZT, Whitehead TA. Standardizing cassette-based deep mutagenesis by Golden Gate assembly. Biotechnol Bioeng. 2024 01; 121(1):281-290.
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Leonard AC, Whitehead TA. Design and engineering of genetically encoded protein biosensors for small molecules. Curr Opin Biotechnol. 2022 Dec; 78:102787.
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Raeeszadeh-Sarmazdeh M, Coban M, Mahajan S, Hockla A, Sankaran B, Downey GP, Radisky DC, Radisky ES. Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10. J Biol Chem. 2022 03; 298(3):101654.
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Kirby MB, Whitehead TA. Facile Assembly of Combinatorial Mutagenesis Libraries Using Nicking Mutagenesis. Methods Mol Biol. 2022; 2461:85-109.
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