 Protein Engineering
"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
| Descriptor ID |
D015202
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| MeSH Number(s) |
E05.393.420.601
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| Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
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Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 0 | 1 | 1 | | 1991 | 1 | 0 | 1 | | 1992 | 0 | 2 | 2 | | 1993 | 0 | 3 | 3 | | 1995 | 0 | 3 | 3 | | 1996 | 1 | 2 | 3 | | 1997 | 1 | 3 | 4 | | 1998 | 2 | 1 | 3 | | 1999 | 0 | 3 | 3 | | 2000 | 1 | 1 | 2 | | 2001 | 1 | 3 | 4 | | 2002 | 3 | 2 | 5 | | 2003 | 2 | 1 | 3 | | 2004 | 4 | 0 | 4 | | 2005 | 3 | 2 | 5 | | 2006 | 3 | 3 | 6 | | 2007 | 0 | 3 | 3 | | 2008 | 6 | 3 | 9 | | 2009 | 5 | 2 | 7 | | 2010 | 2 | 4 | 6 | | 2011 | 6 | 2 | 8 | | 2012 | 7 | 0 | 7 | | 2013 | 10 | 3 | 13 | | 2014 | 7 | 2 | 9 | | 2015 | 5 | 4 | 9 | | 2016 | 7 | 3 | 10 | | 2017 | 6 | 5 | 11 | | 2018 | 4 | 0 | 4 |
To return to the timeline, click here.
Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Shen H, Fallas JA, Lynch E, Sheffler W, Parry B, Jannetty N, Decarreau J, Wagenbach M, Vicente JJ, Chen J, Wang L, Dowling Q, Oberdorfer G, Stewart L, Wordeman L, De Yoreo J, Jacobs-Wagner C, Kollman J, Baker D. De novo design of self-assembling helical protein filaments. Science. 2018 11 09; 362(6415):705-709.
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Singh R. A Novel Saturation Mutagenesis Approach: Single Step Characterization of Regulatory Protein Binding Sites in RNA Using Phosphorothioates. J Vis Exp. 2018 08 21; (138).
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Fox JM, Zhao M, Fink MJ, Kang K, Whitesides GM. The Molecular Origin of Enthalpy/Entropy Compensation in Biomolecular Recognition. Annu Rev Biophys. 2018 05 20; 47:223-250.
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Lu P, Min D, DiMaio F, Wei KY, Vahey MD, Boyken SE, Chen Z, Fallas JA, Ueda G, Sheffler W, Mulligan VK, Xu W, Bowie JU, Baker D. Accurate computational design of multipass transmembrane proteins. Science. 2018 03 02; 359(6379):1042-1046.
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Chaffey PK, Guan X, Li Y, Tan Z. Using Chemical Synthesis To Study and Apply Protein Glycosylation. Biochemistry. 2018 01 30; 57(4):413-428.
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Guan X, Chaffey PK, Wei X, Gulbranson DR, Ruan Y, Wang X, Li Y, Ouyang Y, Chen L, Zeng C, Koelsch TN, Tran AH, Liang W, Shen J, Tan Z. Chemically Precise Glycoengineering Improves Human Insulin. ACS Chem Biol. 2018 01 19; 13(1):73-81.
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Copley SD. Shining a light on enzyme promiscuity. Curr Opin Struct Biol. 2017 12; 47:167-175.
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Lin YR, Koga N, Vorobiev SM, Baker D. Cyclic oligomer design with de novo aß-proteins. Protein Sci. 2017 Nov; 26(11):2187-2194.
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Chevalier A, Silva DA, Rocklin GJ, Hicks DR, Vergara R, Murapa P, Bernard SM, Zhang L, Lam KH, Yao G, Bahl CD, Miyashita SI, Goreshnik I, Fuller JT, Koday MT, Jenkins CM, Colvin T, Carter L, Bohn A, Bryan CM, Fernández-Velasco DA, Stewart L, Dong M, Huang X, Jin R, Wilson IA, Fuller DH, Baker D. Massively parallel de novo protein design for targeted therapeutics. Nature. 2017 10 05; 550(7674):74-79.
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Rocklin GJ, Chidyausiku TM, Goreshnik I, Ford A, Houliston S, Lemak A, Carter L, Ravichandran R, Mulligan VK, Chevalier A, Arrowsmith CH, Baker D. Global analysis of protein folding using massively parallel design, synthesis, and testing. Science. 2017 07 14; 357(6347):168-175.
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