 Protein Engineering
"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
| Descriptor ID |
D015202
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| MeSH Number(s) |
E05.393.420.601
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| Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
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Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 0 | 1 | 1 | | 1991 | 1 | 0 | 1 | | 1992 | 0 | 2 | 2 | | 1993 | 0 | 3 | 3 | | 1995 | 0 | 3 | 3 | | 1996 | 1 | 2 | 3 | | 1997 | 1 | 3 | 4 | | 1998 | 2 | 1 | 3 | | 1999 | 0 | 3 | 3 | | 2000 | 1 | 1 | 2 | | 2001 | 1 | 3 | 4 | | 2002 | 4 | 2 | 6 | | 2003 | 2 | 1 | 3 | | 2004 | 4 | 0 | 4 | | 2005 | 3 | 2 | 5 | | 2006 | 3 | 3 | 6 | | 2007 | 0 | 2 | 2 | | 2008 | 6 | 3 | 9 | | 2009 | 4 | 2 | 6 | | 2010 | 2 | 4 | 6 | | 2011 | 7 | 2 | 9 | | 2012 | 5 | 0 | 5 | | 2013 | 9 | 3 | 12 | | 2014 | 7 | 4 | 11 | | 2015 | 7 | 4 | 11 | | 2016 | 8 | 3 | 11 | | 2017 | 6 | 5 | 11 | | 2018 | 8 | 4 | 12 | | 2019 | 7 | 1 | 8 | | 2020 | 2 | 1 | 3 |
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Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Chen Z, Kibler RD, Hunt A, Busch F, Pearl J, Jia M, VanAernum ZL, Wicky BIM, Dods G, Liao H, Wilken MS, Ciarlo C, Green S, El-Samad H, Stamatoyannopoulos J, Wysocki VH, Jewett MC, Boyken SE, Baker D. De novo design of protein logic gates. Science. 2020 04 03; 368(6486):78-84.
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Brunette TJ, Bick MJ, Hansen JM, Chow CM, Kollman JM, Baker D. Modular repeat protein sculpting using rigid helical junctions. Proc Natl Acad Sci U S A. 2020 04 21; 117(16):8870-8875.
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Wei KY, Moschidi D, Bick MJ, Nerli S, McShan AC, Carter LP, Huang PS, Fletcher DA, Sgourakis NG, Boyken SE, Baker D. Computational design of closely related proteins that adopt two well-defined but structurally divergent folds. Proc Natl Acad Sci U S A. 2020 03 31; 117(13):7208-7215.
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Medina-Cucurella AV, Steiner PJ, Faber MS, Beltrán J, Borelli AN, Kirby MB, Cutler SR, Whitehead TA. User-defined single pot mutagenesis using unamplified oligo pools. Protein Eng Des Sel. 2019 09 10; 32(1):41-45.
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Langan RA, Boyken SE, Ng AH, Samson JA, Dods G, Westbrook AM, Nguyen TH, Lajoie MJ, Chen Z, Berger S, Mulligan VK, Dueber JE, Novak WRP, El-Samad H, Baker D. De novo design of bioactive protein switches. Nature. 2019 08; 572(7768):205-210.
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Machovina MM, Mallinson SJB, Knott BC, Meyers AW, Garcia-Borràs M, Bu L, Gado JE, Oliver A, Schmidt GP, Hinchen DJ, Crowley MF, Johnson CW, Neidle EL, Payne CM, Houk KN, Beckham GT, McGeehan JE, DuBois JL. Enabling microbial syringol conversion through structure-guided protein engineering. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):13970-13976.
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Koepnick B, Flatten J, Husain T, Ford A, Silva DA, Bick MJ, Bauer A, Liu G, Ishida Y, Boykov A, Estep RD, Kleinfelter S, Nørgård-Solano T, Wei L, Players F, Montelione GT, DiMaio F, Popovic Z, Khatib F, Cooper S, Baker D. De novo protein design by citizen scientists. Nature. 2019 06; 570(7761):390-394.
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Boyken SE, Benhaim MA, Busch F, Jia M, Bick MJ, Choi H, Klima JC, Chen Z, Walkey C, Mileant A, Sahasrabuddhe A, Wei KY, Hodge EA, Byron S, Quijano-Rubio A, Sankaran B, King NP, Lippincott-Schwartz J, Wysocki VH, Lee KK, Baker D. De novo design of tunable, pH-driven conformational changes. Science. 2019 05 17; 364(6441):658-664.
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Faber MS, Whitehead TA. Data-driven engineering of protein therapeutics. Curr Opin Biotechnol. 2019 12; 60:104-110.
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Zheng F, Vermaas JV, Zheng J, Wang Y, Tu T, Wang X, Xie X, Yao B, Beckham GT, Luo H. Activity and Thermostability of GH5 Endoglucanase Chimeras from Mesophilic and Thermophilic Parents. Appl Environ Microbiol. 2019 03 01; 85(5).
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