 Protein Engineering
"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
| Descriptor ID |
D015202
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| MeSH Number(s) |
E05.393.420.601
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| Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
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Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 1 | 0 | 1 | | 1992 | 0 | 2 | 2 | | 1993 | 0 | 3 | 3 | | 1995 | 0 | 3 | 3 | | 1996 | 1 | 2 | 3 | | 1997 | 1 | 3 | 4 | | 1998 | 2 | 1 | 3 | | 1999 | 0 | 3 | 3 | | 2000 | 1 | 1 | 2 | | 2001 | 1 | 3 | 4 | | 2002 | 2 | 1 | 3 | | 2003 | 0 | 1 | 1 | | 2004 | 3 | 0 | 3 | | 2005 | 2 | 1 | 3 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 2 | 2 | | 2008 | 5 | 3 | 8 | | 2009 | 2 | 2 | 4 | | 2010 | 0 | 2 | 2 | | 2011 | 2 | 2 | 4 | | 2013 | 3 | 1 | 4 | | 2014 | 2 | 2 | 4 | | 2015 | 2 | 2 | 4 | | 2016 | 4 | 3 | 7 | | 2017 | 2 | 2 | 4 | | 2018 | 3 | 4 | 7 | | 2019 | 4 | 1 | 5 | | 2020 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Knott BC, Erickson E, Allen MD, Gado JE, Graham R, Kearns FL, Pardo I, Topuzlu E, Anderson JJ, Austin HP, Dominick G, Johnson CW, Rorrer NA, Szostkiewicz CJ, Copié V, Payne CM, Woodcock HL, Donohoe BS, Beckham GT, McGeehan JE. Characterization and engineering of a two-enzyme system for plastics depolymerization. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25476-25485.
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Medina-Cucurella AV, Steiner PJ, Faber MS, Beltrán J, Borelli AN, Kirby MB, Cutler SR, Whitehead TA. User-defined single pot mutagenesis using unamplified oligo pools. Protein Eng Des Sel. 2019 09 10; 32(1):41-45.
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Machovina MM, Mallinson SJB, Knott BC, Meyers AW, Garcia-Borràs M, Bu L, Gado JE, Oliver A, Schmidt GP, Hinchen DJ, Crowley MF, Johnson CW, Neidle EL, Payne CM, Houk KN, Beckham GT, McGeehan JE, DuBois JL. Enabling microbial syringol conversion through structure-guided protein engineering. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):13970-13976.
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Faber MS, Whitehead TA. Data-driven engineering of protein therapeutics. Curr Opin Biotechnol. 2019 12; 60:104-110.
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Zheng F, Vermaas JV, Zheng J, Wang Y, Tu T, Wang X, Xie X, Yao B, Beckham GT, Luo H. Activity and Thermostability of GH5 Endoglucanase Chimeras from Mesophilic and Thermophilic Parents. Appl Environ Microbiol. 2019 03 01; 85(5).
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Wrenbeck EE, Bedewitz MA, Klesmith JR, Noshin S, Barry CS, Whitehead TA. An Automated Data-Driven Pipeline for Improving Heterologous Enzyme Expression. ACS Synth Biol. 2019 03 15; 8(3):474-481.
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Collins LT, Otoupal PB, Campos JK, Courtney CM, Chatterjee A. Design of a De Novo Aggregating Antimicrobial Peptide and a Bacterial Conjugation-Based Delivery System. Biochemistry. 2019 03 19; 58(11):1521-1526.
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Manna P, Hung ST, Mukherjee S, Friis P, Simpson DM, Lo MN, Palmer AE, Jimenez R. Directed evolution of excited state lifetime and brightness in FusionRed using a microfluidic sorter. Integr Biol (Camb). 2018 09 17; 10(9):516-526.
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Singh R. A Novel Saturation Mutagenesis Approach: Single Step Characterization of Regulatory Protein Binding Sites in RNA Using Phosphorothioates. J Vis Exp. 2018 08 21; (138).
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Fudge DH, Black R, Son L, LeJeune K, Qin Y. Optical Recording of Zn2+ Dynamics in the Mitochondrial Matrix and Intermembrane Space with the GZnP2 Sensor. ACS Chem Biol. 2018 07 20; 13(7):1897-1905.
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