 Hydrolases
"Hydrolases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
| Descriptor ID |
D006867
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| MeSH Number(s) |
D08.811.277
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hydrolases".
Below are MeSH descriptors whose meaning is more specific than "Hydrolases".
This graph shows the total number of publications written about "Hydrolases" by people in this website by year, and whether "Hydrolases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 | | 1997 | 0 | 2 | 2 | | 1998 | 1 | 0 | 1 | | 2000 | 1 | 0 | 1 | | 2002 | 3 | 0 | 3 | | 2005 | 1 | 0 | 1 | | 2006 | 2 | 0 | 2 | | 2007 | 3 | 0 | 3 | | 2008 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2017 | 2 | 0 | 2 | | 2020 | 1 | 2 | 3 | | 2021 | 3 | 3 | 6 | | 2022 | 2 | 0 | 2 | | 2023 | 0 | 2 | 2 | | 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Hydrolases" by people in Profiles.
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Norton-Baker B, Denton MCR, Murphy NP, Fram B, Lim S, Erickson E, Gauthier NP, Beckham GT. Enabling high-throughput enzyme discovery and engineering with a low-cost, robot-assisted pipeline. Sci Rep. 2024 06 24; 14(1):14449.
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Zhong-Johnson EZL, Dong Z, Canova CT, Destro F, Ca?ellas M, Hoffman MC, Mar?chal J, Johnson TM, Zheng M, Schlau-Cohen GS, Lucas MF, Braatz RD, Sprenger KG, Voigt CA, Sinskey AJ. Analysis of Poly(ethylene terephthalate) degradation kinetics of evolved IsPETase variants using a surface crowding model. J Biol Chem. 2024 03; 300(3):105783.
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Klontz E, Obi JO, Wang Y, Glendening G, Carr J, Tsibouris C, Buddula S, Nallar S, Soares AS, Beckett D, Redzic JS, Eisenmesser E, Palm C, Schmidt K, Scudder AH, Obiorah T, Essuman K, Milbrandt J, Diantonio A, Ray K, Snyder MLD, Deredge D, Snyder GA. The structure of NAD+ consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations. J Biol Chem. 2023 11; 299(11):105290.
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Avilan L, Lichtenstein BR, K?nig G, Zahn M, Allen MD, Oliveira L, Clark M, Bemmer V, Graham R, Austin HP, Dominick G, Johnson CW, Beckham GT, McGeehan JE, Pickford AR. Concentration-Dependent Inhibition of Mesophilic PETases on Poly(ethylene terephthalate) Can Be Eliminated by Enzyme Engineering. ChemSusChem. 2023 Apr 21; 16(8):e202202277.
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Erickson E, Gado JE, Avil?n L, Bratti F, Brizendine RK, Cox PA, Gill R, Graham R, Kim DJ, K?nig G, Michener WE, Poudel S, Ramirez KJ, Shakespeare TJ, Zahn M, Boyd ES, Payne CM, DuBois JL, Pickford AR, Beckham GT, McGeehan JE. Sourcing thermotolerant poly(ethylene terephthalate) hydrolase scaffolds from natural diversity. Nat Commun. 2022 12 21; 13(1):7850.
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Nguyen TT, Voeltz GK. An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion. Elife. 2022 11 30; 11.
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Erickson E, Shakespeare TJ, Bratti F, Buss BL, Graham R, Hawkins MA, K?nig G, Michener WE, Miscall J, Ramirez KJ, Rorrer NA, Zahn M, Pickford AR, McGeehan JE, Beckham GT. Comparative Performance of PETase as a Function of Reaction Conditions, Substrate Properties, and Product Accumulation. ChemSusChem. 2022 Jan 10; 15(1):e202102517.
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Erickson E, Shakespeare TJ, Bratti F, Buss BL, Graham R, Hawkins MA, K?nig G, Michener WE, Miscall J, Ramirez KJ, Rorrer NA, Zahn M, Pickford AR, McGeehan JE, Beckham GT. Comparative Performance of PETase as a Function of Reaction Conditions, Substrate Properties, and Product Accumulation. ChemSusChem. 2022 Jan 10; 15(1):e202101932.
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Werner AZ, Clare R, Mand TD, Pardo I, Ramirez KJ, Haugen SJ, Bratti F, Dexter GN, Elmore JR, Huenemann JD, Peabody GL, Johnson CW, Rorrer NA, Salvach?a D, Guss AM, Beckham GT. Tandem chemical deconstruction and biological upcycling of poly(ethylene terephthalate) to ?-ketoadipic acid by Pseudomonas putida KT2440. Metab Eng. 2021 09; 67:250-261.
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Demoruelle MK, Wang H, Davis RL, Visser A, Hoang J, Norris JM, Holers VM, Deane KD, Darrah E. Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis. Arthritis Res Ther. 2021 06 06; 23(1):163.
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