 Holoenzymes
"Holoenzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Catalytically active enzymes that are formed by the combination of an apoenzyme (APOENZYMES) and its appropriate cofactors and prosthetic groups.
| Descriptor ID |
D020035
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| MeSH Number(s) |
D08.811.255
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Holoenzymes".
Below are MeSH descriptors whose meaning is more specific than "Holoenzymes".
This graph shows the total number of publications written about "Holoenzymes" by people in this website by year, and whether "Holoenzymes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Holoenzymes" by people in Profiles.
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Nahar A, Sokolova V, Sekaran S, Orth JD, Park S. Assembly checkpoint of the proteasome regulatory particle is activated by coordinated actions of proteasomal ATPase chaperones. Cell Rep. 2022 06 07; 39(10):110918.
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Buonarati OR, Miller AP, Coultrap SJ, Bayer KU, Reichow SL. Conserved and divergent features of neuronal CaMKII holoenzyme structure, function, and high-order assembly. Cell Rep. 2021 12 28; 37(13):110168.
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Nahar A, Fu X, Polovin G, Orth JD, Park S. Two alternative mechanisms regulate the onset of chaperone-mediated assembly of the proteasomal ATPases. J Biol Chem. 2019 04 19; 294(16):6562-6577.
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Cook SG, Bourke AM, O'Leary H, Zaegel V, Lasda E, Mize-Berge J, Quillinan N, Tucker CL, Coultrap SJ, Herson PS, Bayer KU. Analysis of the CaMKIIa and ? splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep. 2018 04 03; 8(1):5448.
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Tsai KL, Yu X, Gopalan S, Chao TC, Zhang Y, Florens L, Washburn MP, Murakami K, Conaway RC, Conaway JW, Asturias FJ. Mediator structure and rearrangements required for holoenzyme formation. Nature. 2017 04 13; 544(7649):196-201.
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Sato S, Tomomori-Sato C, Tsai KL, Yu X, Sardiu M, Saraf A, Washburn MP, Florens L, Asturias FJ, Conaway RC, Conaway JW. Role for the MED21-MED7 Hinge in Assembly of the Mediator-RNA Polymerase II Holoenzyme. J Biol Chem. 2016 Dec 23; 291(52):26886-26898.
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Dohrmann PR, Correa R, Frisch RL, Rosenberg SM, McHenry CS. The DNA polymerase III holoenzyme contains ? and is not a trimeric polymerase. Nucleic Acids Res. 2016 Feb 18; 44(3):1285-97.
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Stanevich V, Zheng A, Guo F, Jiang L, Wlodarchak N, Xing Y. Mechanisms of the scaffold subunit in facilitating protein phosphatase 2A methylation. PLoS One. 2014; 9(1):e86955.
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Honarpour N, Rose CM, Brumbaugh J, Anderson J, Graham RL, Sweredoski MJ, Hess S, Coon JJ, Deshaies RJ. F-box protein FBXL16 binds PP2A-B55a and regulates differentiation of embryonic stem cells along the FLK1+ lineage. Mol Cell Proteomics. 2014 Mar; 13(3):780-91.
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Wlodarchak N, Guo F, Satyshur KA, Jiang L, Jeffrey PD, Sun T, Stanevich V, Mumby MC, Xing Y. Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation. Cell Res. 2013 Jul; 23(7):931-46.
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