Nuclear Receptor Co-Repressor 2
"Nuclear Receptor Co-Repressor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear co-repressor protein that shows specificity for RETINOIC ACID RECEPTORS and THYROID HORMONE RECEPTORS. The dissociation of this co-repressor from nuclear receptors is generally ligand-dependent, but can also occur by way of its phosphorylation by members of the MAP KINASE SIGNALING SYSTEM. The protein contains two nuclear receptor interaction domains and four repressor domains and is closely-related in structure to NUCLEAR RECEPTOR CO-REPRESSOR 1.
Descriptor ID |
D056985
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MeSH Number(s) |
D12.776.930.780.625.400
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Concept/Terms |
Nuclear Receptor Co-Repressor 2- Nuclear Receptor Co-Repressor 2
- Nuclear Receptor Co Repressor 2
- TRAC Co-repressor
- Co-repressor, TRAC
- TRAC Co repressor
- SMRT Co-repressor
- Co-repressor, SMRT
- SMRT Co repressor
- Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor
- T3 Receptor-associating Factor
- Receptor-associating Factor, T3
- T3 Receptor associating Factor
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Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Co-Repressor 2".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Co-Repressor 2".
This graph shows the total number of publications written about "Nuclear Receptor Co-Repressor 2" by people in this website by year, and whether "Nuclear Receptor Co-Repressor 2" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 1 | 1 | 2000 | 0 | 1 | 1 | 2012 | 1 | 0 | 1 | 2016 | 0 | 1 | 1 | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nuclear Receptor Co-Repressor 2" by people in Profiles.
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Fisher MH, Kirkpatrick GD, Stevens B, Jones C, Callaghan M, Rajpurkar M, Fulbright J, Cooper MA, Rowley J, Porter CC, Gutierrez-Hartmann A, Jones K, Jordan C, Pietras EM, Di Paola J. ETV6 germline mutations cause HDAC3/NCOR2 mislocalization and upregulation of interferon response genes. JCI Insight. 2020 09 17; 5(18).
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Balasubramaniyan N, Ananthanarayanan M, Suchy FJ. Nuclear factor-?B regulates the expression of multiple genes encoding liver transport proteins. Am J Physiol Gastrointest Liver Physiol. 2016 04 15; 310(8):G618-28.
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Wargon V, Riggio M, Giulianelli S, Sequeira GR, Rojas P, May M, Polo ML, Gorostiaga MA, Jacobsen B, Molinolo A, Novaro V, Lanari C. Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters. Int J Cancer. 2015 Jun 01; 136(11):2680-92.
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Guo L, Chen C, Liang Q, Karim MZ, Gorska MM, Alam R. Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor. J Immunol. 2013 Jan 01; 190(1):159-67.
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Tjalkens RB, Liu X, Mohl B, Wright T, Moreno JA, Carbone DL, Safe S. The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells. J Neurosci Res. 2008 Feb 15; 86(3):618-29.
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Graham JD, Bain DL, Richer JK, Jackson TA, Tung L, Horwitz KB. Thoughts on tamoxifen resistant breast cancer. Are coregulators the answer or just a red herring? J Steroid Biochem Mol Biol. 2000 Nov 30; 74(5):255-9.
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Jackson TA, Richer JK, Bain DL, Takimoto GS, Tung L, Horwitz KB. The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT. Mol Endocrinol. 1997 Jun; 11(6):693-705.
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