 alpha 1-Antichymotrypsin
"alpha 1-Antichymotrypsin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Glycoprotein found in alpha(1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.
| Descriptor ID |
D000514
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| MeSH Number(s) |
D12.644.861.030 D12.776.124.050.050 D12.776.124.790.106.050 D12.776.377.715.085.050 D12.776.395.045 D12.776.872.030
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "alpha 1-Antichymotrypsin".
Below are MeSH descriptors whose meaning is more specific than "alpha 1-Antichymotrypsin".
This graph shows the total number of publications written about "alpha 1-Antichymotrypsin" by people in this website by year, and whether "alpha 1-Antichymotrypsin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "alpha 1-Antichymotrypsin" by people in Profiles.
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Padmanabhan J, Levy M, Dickson DW, Potter H. Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain. 2006 Nov; 129(Pt 11):3020-34.
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Nilsson LN, Arendash GW, Leighty RE, Costa DA, Low MA, Garcia MF, Cracciolo JR, Rojiani A, Wu X, Bales KR, Paul SM, Potter H. Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation. Neurobiol Aging. 2004 Oct; 25(9):1153-67.
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Potter H, Wefes IM, Nilsson LN. The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation. Neurobiol Aging. 2001 Nov-Dec; 22(6):923-30.
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Kamboh MI, Sanghera DK, Aston CE, Bunker CH, Hamman RF, Ferrell RE, DeKosky ST. Gender-specific nonrandom association between the alpha 1-antichymotrypsin and apolipoprotein E polymorphisms in the general population and its implication for the risk of Alzheimer's disease. Genet Epidemiol. 1997; 14(2):169-80.
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