 Methyltransferases
"Methyltransferases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.
| Descriptor ID |
D008780
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| MeSH Number(s) |
D08.811.913.555.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Methyltransferases".
Below are MeSH descriptors whose meaning is more specific than "Methyltransferases".
This graph shows the total number of publications written about "Methyltransferases" by people in this website by year, and whether "Methyltransferases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 | | 2000 | 2 | 0 | 2 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 2 | 2 | | 2010 | 0 | 1 | 1 | | 2012 | 1 | 1 | 2 | | 2013 | 0 | 1 | 1 | | 2014 | 3 | 0 | 3 | | 2015 | 2 | 1 | 3 | | 2016 | 1 | 4 | 5 | | 2017 | 1 | 2 | 3 | | 2018 | 2 | 1 | 3 | | 2019 | 0 | 1 | 1 | | 2020 | 3 | 0 | 3 | | 2021 | 2 | 0 | 2 | | 2022 | 1 | 0 | 1 | | 2023 | 2 | 0 | 2 | | 2024 | 1 | 1 | 2 | | 2025 | 2 | 1 | 3 |
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Below are the most recent publications written about "Methyltransferases" by people in Profiles.
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Tsai YL, Wolf EJ, Fluke KA, Fuchs RT, Dai N, Johnson SR, Sun Z, Elkins L, Burkhart BW, Santangelo TJ, Corr?a IR. Comprehensive nucleoside analysis of archaeal RNA modification profiles reveals an m7G in the conserved P loop of 23S rRNA. Cell Rep. 2025 Apr 22; 44(4):115471.
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Gonskikh Y, Tirrito C, Bommisetti P, Mendoza-Figueroa MS, Stoute J, Kim J, Wang Q, Song Y, Liu KF. Spatial regulation of NSUN2-mediated tRNA m5C installation in cognitive function. Nucleic Acids Res. 2025 Jan 11; 53(2).
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Wei X, Sampson N, Figueroa Mendoza SM, Gonskikh Y, Liu KF. Fault-Tolerance Study on a Positive-Charged Cleft in 18S rRNA Methyltransferase DIMT1. Biochemistry. 2025 01 21; 64(2):525-532.
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Fluke KA, Dai N, Wolf EJ, Fuchs RT, Ho PS, Talbott V, Elkins L, Tsai YL, Schiltz J, Febvre HP, Czarny R, Robb GB, Corr?a IR, Santangelo TJ. A novel N4,N4-dimethylcytidine in the archaeal ribosome enhances hyperthermophily. Proc Natl Acad Sci U S A. 2024 Nov 05; 121(45):e2405999121.
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Fluke KA, Fuchs RT, Tsai YL, Talbott V, Elkins L, Febvre HP, Dai N, Wolf EJ, Burkhart BW, Schiltz J, Brett Robb G, Corr?a IR, Santangelo TJ. The extensive m5C epitranscriptome of Thermococcus kodakarensis is generated by a suite of RNA methyltransferases that support thermophily. Nat Commun. 2024 Aug 23; 15(1):7272.
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Maldonado L?pez AM, Ko EK, Huang S, Pacella G, Kuprasertkul N, D'souza CA, Reyes Hueros RA, Shen H, Stoute J, Elashal H, Sinkfield M, Anderson A, Prouty S, Li HB, Seykora JT, Liu KF, Capell BC. Mettl3-catalyzed m6A regulates histone modifier and modification expression in self-renewing somatic tissue. Sci Adv. 2023 09; 9(35):eadg5234.
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Gonskikh Y, Stoute J, Shen H, Budinich K, Pingul B, Schultz K, Elashal H, Marmorstein R, Shi J, Liu KF. Noncatalytic regulation of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia. Genes Dev. 2023 04 01; 37(7-8):321-335.
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Chen Y, Lu Z, Qi C, Yu C, Li Y, Huan W, Wang R, Luo W, Shen D, Ding L, Ren L, Xie H, Xue D, Wang M, Ni K, Xia L, Qian J, Li G. N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma. Mol Cancer. 2022 05 10; 21(1):111.
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Shen H, Gonskikh Y, Stoute J, Liu KF. Human DIMT1 generates N26,6A-dimethylation-containing small RNAs. J Biol Chem. 2021 10; 297(4):101146.
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Basu S, Mak T, Ulferts R, Wu M, Deegan T, Fujisawa R, Tan KW, Lim CT, Basier C, Canal B, Curran JF, Drury LS, McClure AW, Roberts EL, Weissmann F, Zeisner TU, Beale R, Cowling VH, Howell M, Labib K, Diffley JFX. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase. Biochem J. 2021 07 16; 478(13):2481-2497.
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