 Catechol O-Methyltransferase
"Catechol O-Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.
| Descriptor ID |
D002394
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| MeSH Number(s) |
D08.811.913.555.500.250
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| Concept/Terms |
Catechol O-Methyltransferase- Catechol O-Methyltransferase
- O-Methyltransferase, Catechol
- Catechol-O-Methyltransferase
- Catechol O Methyltransferase
- Catechol Methyltransferase
- Methyltransferase, Catechol
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Below are MeSH descriptors whose meaning is more general than "Catechol O-Methyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Catechol O-Methyltransferase".
This graph shows the total number of publications written about "Catechol O-Methyltransferase" by people in this website by year, and whether "Catechol O-Methyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2010 | 1 | 1 | 2 | | 2011 | 2 | 0 | 2 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2020 | 2 | 0 | 2 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Catechol O-Methyltransferase" by people in Profiles.
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Schacht JP, Hoffman M, Voronin KE, Book SW, Anton RF. Effects of pharmacological and genetic regulation of COMT activity in alcohol use disorder: a randomized, placebo-controlled trial of tolcapone. Neuropsychopharmacology. 2022 10; 47(11):1953-1960.
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Crews KR, Monte AA, Huddart R, Caudle KE, Kharasch ED, Gaedigk A, Dunnenberger HM, Leeder JS, Callaghan JT, Samer CF, Klein TE, Haidar CE, Van Driest SL, Ruano G, Sangkuhl K, Cavallari LH, M?ller DJ, Prows CA, Nagy M, Somogyi AA, Skaar TC. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy. Clin Pharmacol Ther. 2021 10; 110(4):888-896.
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Anton RF, Voronin KE, Book SW, Latham PK, Randall PK, Glen WB, Hoffman M, Schacht JP. Opioid and Dopamine Genes Interact to Predict Naltrexone Response in a Randomized Alcohol Use Disorder Clinical Trial. Alcohol Clin Exp Res. 2020 10; 44(10):2084-2096.
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Zhang J, Balsbaugh JL, Gao S, Ahn NG, Klinman JP. Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol O-methyltransferase reaction. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):10797-10805.
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Schacht JP, Voronin KE, Randall PK, Anton RF. Dopaminergic Genetic Variation Influences Aripiprazole Effects on Alcohol Self-Administration and the Neural Response to Alcohol Cues in a Randomized Trial. Neuropsychopharmacology. 2018 05; 43(6):1247-1256.
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Leerkes EM, Gedaly LR, Zhou N, Calkins S, Henrich VC, Smolen A. Further evidence of the limited role of candidate genes in relation to infant-mother attachment outcomes. Attach Hum Dev. 2017 Feb; 19(1):76-105.
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Patanwala IY, Lamvu G, Ledger WJ, Witzeman K, Marvel R, Rapkin A, Bongiovanni AM, Feranec J, Witkin SS. Catechol-O-methyltransferase gene polymorphism and vulvar pain in women with vulvodynia. Am J Obstet Gynecol. 2017 Apr; 216(4):395.e1-395.e6.
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Schacht JP. COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review. Pharmacogenomics J. 2016 10; 16(5):430-8.
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Ross RS, Medrano P, Boyle K, Smolen A, Curran T, Nyhus E. Genetic variation in the serotonin transporter gene influences ERP old/new effects during recognition memory. Neuropsychologia. 2015 Nov; 78:95-107.
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Wachman EM, Hayes MJ, Sherva R, Brown MS, Davis JM, Farrer LA, Nielsen DA. Variations in opioid receptor genes in neonatal abstinence syndrome. Drug Alcohol Depend. 2015 Oct 01; 155:253-9.
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