 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
"5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC 2.1.1.13.
| Descriptor ID |
D013766
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| MeSH Number(s) |
D08.811.913.555.500.645
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| Concept/Terms |
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase- 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
- S-Methyltransferase, 5-Methyltetrahydrofolate-Homocysteine
- Methyltetrahydrofolate Homocysteine Methyltransferase
- Homocysteine Methyltransferase, Methyltetrahydrofolate
- Methyltransferase, Methyltetrahydrofolate Homocysteine
- Methionine Synthase
- Synthase, Methionine
- Methionine Synthetase
- Synthetase, Methionine
- Tetrahydropteroylglutamate Methyltransferase
- Methyltransferase, Tetrahydropteroylglutamate
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Below are MeSH descriptors whose meaning is more general than "5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase".
Below are MeSH descriptors whose meaning is more specific than "5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase".
This graph shows the total number of publications written about "5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase" by people in this website by year, and whether "5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase" by people in Profiles.
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Kripps KA, Sremba L, Larson AA, Van Hove JLK, Nguyen H, Wright EL, Mirsky DM, Watkins D, Rosenblatt DS, Ketteridge D, Berry SA, McCandless SE, Baker PR. Methionine synthase deficiency: Variable clinical presentation and benefit of early diagnosis and treatment. J Inherit Metab Dis. 2022 03; 45(2):157-168.
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Sremba L, McCandless S, Baker P. Concerning "Diagnostic Exome Sequencing and Tailored Bioinformatics of the Parents of a Deceased Child with Cobalamin Deficiency Suggests Digenic Inheritance of the MTR and LMBRD1 Genes" by Farwell Gonzalez et al. J Inherit Metab Dis. 2020 03; 43(2):157-158.
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McDonald MK, Fritz JA, Jia D, Scheuchner D, Snyder FF, Stanislaus A, Curle J, Li L, Stabler SP, Allen RH, Mains PE, Gravel RA. Identification of ABC transporters acting in vitamin B12 metabolism in Caenorhabditis elegans. Mol Genet Metab. 2017 12; 122(4):160-171.
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Barbosa PR, Stabler SP, Machado AL, Braga RC, Hirata RD, Hirata MH, Sampaio-Neto LF, Allen RH, Guerra-Shinohara EM. Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women. Eur J Clin Nutr. 2008 Aug; 62(8):1010-21.
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Skibola CF, Smith MT, Hubbard A, Shane B, Roberts AC, Law GR, Rollinson S, Roman E, Cartwright RA, Morgan GJ. Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood. 2002 May 15; 99(10):3786-91.
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Thompson HR, Jones GM, Narkewicz MR. Ontogeny of hepatic enzymes involved in serine- and folate-dependent one-carbon metabolism in rabbits. Am J Physiol Gastrointest Liver Physiol. 2001 May; 280(5):G873-8.
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Halsted CH, Villanueva J, Chandler CJ, Stabler SP, Allen RH, Muskhelishvili L, James SJ, Poirier L. Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology. 1996 Mar; 23(3):497-505.
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Allen RH, Stabler SP, Savage DG, Lindenbaum J. Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J. 1993 Nov; 7(14):1344-53.
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Kolhouse JF, Stabler SP, Allen RH. Identification and perturbation of mutant human fibroblasts based on measurements of methylmalonic acid and total homocysteine in the culture media. Arch Biochem Biophys. 1993 Jun; 303(2):355-60.
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Kolhouse JF, Utley C, Stabler SP, Allen RH. Mechanism of conversion of human apo- to holomethionine synthase by various forms of cobalamin. J Biol Chem. 1991 Dec 05; 266(34):23010-5.
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