 Andrew David Klocko
| Title | Asst Professor |
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| Department | LAS-Chemistry |
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 Research R15GM140396 (KLOCKO, ANDREW DAVID)Sep 10, 2020 - Aug 31, 2023 NIH
Genome topology in the filamentous fungus Neurospora crassa: organizing factors and impact on genome function
Role: Principal Investigator |
| F32GM097821 (KLOCKO, ANDREW DAVID)Jul 1, 2012 - Jun 30, 2014 NIH
Genetic analysis of DNA methylation in Neurospora crassa
Role: Principal Investigator |
Bibliographic
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Scadden AW, Graybill AS, Hull-Crew C, Lundberg TJ, Lande NM, Klocko AD. Histone deacetylation and cytosine methylation compartmentalize heterochromatic regions in the genome organization of Neurospora crassa. Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47):e2311249120. PMID: 37963248.
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Scadden AW, Graybill AS, Hull-Crew C, Lundberg TJ, Lande NM, Klocko AD. Histone deacetylation and cytosine methylation compartmentalize heterochromatic regions in the genome organization of Neurospora crassa. bioRxiv. 2023 Sep 23. PMID: 37461718.
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Torres DE, Reckard AT, Klocko AD, Seidl MF. Nuclear genome organization in fungi: from gene folding to Rabl chromosomes. FEMS Microbiol Rev. 2023 05 19; 47(3). PMID: 37197899.
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Rodriguez S, Ward A, Reckard AT, Shtanko Y, Hull-Crew C, Klocko AD. The genome organization of Neurospora crassa at high resolution uncovers principles of fungal chromosome topology. G3 (Bethesda). 2022 05 06; 12(5). PMID: 35244156.
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Klocko AD, Summers CA, Glover ML, Parrish R, Storck WK, McNaught KJ, Moss ND, Gotting K, Stewart A, Morrison AM, Payne L, Hatakeyama S, Selker EU. Selection and Characterization of Mutants Defective in DNA Methylation in Neurospora crassa. Genetics. 2020 11; 216(3):671-688. PMID: 32873602.
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Klocko AD, Uesaka M, Ormsby T, Rountree MR, Wiles ET, Adhvaryu KK, Honda S, Selker EU. Nucleosome Positioning by an Evolutionarily Conserved Chromatin Remodeler Prevents Aberrant DNA Methylation in Neurospora. Genetics. 2019 02; 211(2):563-578. PMID: 30554169.
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Wilinski D, Buter N, Klocko AD, Lapointe CP, Selker EU, Gasch AP, Wickens M. Reply to Hogan: Direct evidence of RNA-protein interactions and rewiring. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):E10854-E10855. PMID: 29208722.
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Wilinski D, Buter N, Klocko AD, Lapointe CP, Selker EU, Gasch AP, Wickens M. Recurrent rewiring and emergence of RNA regulatory networks. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2816-E2825. PMID: 28320951.
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Klocko AD, Ormsby T, Galazka JM, Leggett NA, Uesaka M, Honda S, Freitag M, Selker EU. Normal chromosome conformation depends on subtelomeric facultative heterochromatin in Neurospora crassa. Proc Natl Acad Sci U S A. 2016 12 27; 113(52):15048-15053. PMID: 27856763.
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Galazka JM, Klocko AD, Uesaka M, Honda S, Selker EU, Freitag M. Neurospora chromosomes are organized by blocks of importin alpha-dependent heterochromatin that are largely independent of H3K9me3. Genome Res. 2016 08; 26(8):1069-80. PMID: 27260477.
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Klocko AD, Rountree MR, Grisafi PL, Hays SM, Adhvaryu KK, Selker EU. Neurospora importin a is required for normal heterochromatic formation and DNA methylation. PLoS Genet. 2015 Mar; 11(3):e1005083. PMID: 25793375.
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Klocko AD, Schroeder JW, Walsh BW, Lenhart JS, Evans ML, Simmons LA. Mismatch repair causes the dynamic release of an essential DNA polymerase from the replication fork. Mol Microbiol. 2011 Nov; 82(3):648-63. PMID: 21958350.
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Pillon MC, Lorenowicz JJ, Uckelmann M, Klocko AD, Mitchell RR, Chung YS, Modrich P, Walker GC, Simmons LA, Friedhoff P, Guarn? A. Structure of the endonuclease domain of MutL: unlicensed to cut. Mol Cell. 2010 Jul 09; 39(1):145-51. PMID: 20603082.
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Dupes NM, Walsh BW, Klocko AD, Lenhart JS, Peterson HL, Gessert DA, Pavlick CE, Simmons LA. Mutations in the Bacillus subtilis beta clamp that separate its roles in DNA replication from mismatch repair. J Bacteriol. 2010 Jul; 192(13):3452-63. PMID: 20453097.
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Klocko AD, Crafton KM, Walsh BW, Lenhart JS, Simmons LA. Imaging mismatch repair and cellular responses to DNA damage in Bacillus subtilis. J Vis Exp. 2010 Feb 08; (36). PMID: 20142799.
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Klocko AD, Wassarman KM. 6S RNA binding to Esigma(70) requires a positively charged surface of sigma(70) region 4.2. Mol Microbiol. 2009 Jul; 73(2):152-64. PMID: 19538447.
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Cavanagh AT, Klocko AD, Liu X, Wassarman KM. Promoter specificity for 6S RNA regulation of transcription is determined by core promoter sequences and competition for region 4.2 of sigma70. Mol Microbiol. 2008 Mar; 67(6):1242-56. PMID: 18208528.
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Kim W, Koo H, Richman AM, Seeley D, Vizioli J, Klocko AD, O'Brochta DA. Ectopic expression of a cecropin transgene in the human malaria vector mosquito Anopheles gambiae (Diptera: Culicidae): effects on susceptibility to Plasmodium. J Med Entomol. 2004 May; 41(3):447-55. PMID: 15185949.
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Wilson R, Orsetti J, Klocko AD, Aluvihare C, Peckham E, Atkinson PW, Lehane MJ, O'Brochta DA. Post-integration behavior of a Mos1 mariner gene vector in Aedes aegypti. Insect Biochem Mol Biol. 2003 Sep; 33(9):853-63. PMID: 12915177.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2003 | 1 | | 2004 | 1 | | 2008 | 1 | | 2009 | 1 | | 2010 | 3 | | 2011 | 1 | | 2015 | 1 | | 2016 | 2 | | 2017 | 2 | | 2018 | 1 | | 2020 | 1 | | 2022 | 1 | | 2023 | 3 |
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