 5-Methylcytosine
"5-Methylcytosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A methylated nucleotide base found in eukaryotic DNA. In ANIMALS, the DNA METHYLATION of CYTOSINE to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In PLANTS, the methylated sequence is CpNpGp, where N can be any base.
| Descriptor ID |
D044503
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| MeSH Number(s) |
D03.383.742.698.421.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "5-Methylcytosine".
Below are MeSH descriptors whose meaning is more specific than "5-Methylcytosine".
This graph shows the total number of publications written about "5-Methylcytosine" by people in this website by year, and whether "5-Methylcytosine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2014 | 1 | 1 | 2 | | 2016 | 3 | 0 | 3 | | 2017 | 1 | 2 | 3 | | 2019 | 1 | 1 | 2 | | 2020 | 2 | 0 | 2 | | 2021 | 1 | 0 | 1 | | 2024 | 0 | 1 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "5-Methylcytosine" by people in Profiles.
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Gonskikh Y, Tirrito C, Bommisetti P, Mendoza-Figueroa MS, Stoute J, Kim J, Wang Q, Song Y, Liu KF. Spatial regulation of NSUN2-mediated tRNA m5C installation in cognitive function. Nucleic Acids Res. 2025 Jan 11; 53(2).
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Zhang J, Li H, Niswander LA. m5C methylated lncRncr3-MeCP2 interaction restricts miR124a-initiated neurogenesis. Nat Commun. 2024 Jun 15; 15(1):5136.
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Baum C, Lin YC, Fomenkov A, Anton BP, Chen L, Yan B, Evans TC, Roberts RJ, Tolonen AC, Ettwiller L. Rapid identification of methylase specificity (RIMS-seq) jointly identifies methylated motifs and generates shotgun sequencing of bacterial genomes. Nucleic Acids Res. 2021 11 08; 49(19):e113.
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Shen H, Ontiveros RJ, Owens MC, Liu MY, Ghanty U, Kohli RM, Liu KF. TET-mediated 5-methylcytosine oxidation in tRNA promotes?translation. J Biol Chem. 2021 Jan-Jun; 296:100087.
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Vander Zanden CM, Czarny RS, Ho EN, Robertson AB, Ho PS. Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function. Nucleic Acids Res. 2020 04 17; 48(7):3962-3974.
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Applebaum MA, Barr EK, Karpus J, West-Szymanski DC, Oliva M, Sokol EA, Zhang S, Zhang Z, Zhang W, Chlenski A, Salwen HR, Wilkinson E, Dobratic M, Grossman RL, Godley LA, Stranger BE, He C, Cohn SL. 5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma. Clin Cancer Res. 2020 03 15; 26(6):1309-1317.
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Yanas A, Liu KF. RNA modifications and the link to human disease. Methods Enzymol. 2019; 626:133-146.
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Leti F, Llaci L, Malenica I, DiStefano JK. Methods for CpG Methylation Array Profiling Via Bisulfite Conversion. Methods Mol Biol. 2018; 1706:233-254.
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Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR. Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes. Cell Rep. 2017 12 26; 21(13):3700-3707.
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Ellison EM, Bradley-Whitman MA, Lovell MA. Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer's Disease Subjects. J Mol Neurosci. 2017 Oct; 63(2):185-197.
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