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Vienna E Brunt

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
    Other Positions
    TitleAsst Professor Adjunct
    InstitutionUniversity of Colorado Boulder
    DepartmentIntegrative Physiology


    Collapse Research 
    Collapse research activities and funding
    R00HL151818     (BRUNT, VIENNA E)May 1, 2022 - Apr 30, 2025
    NIH
    Translational Studies of the Short-Chain Fatty Acid Acetate for Improving Age-Associated Arterial Dysfunction
    Role: Principal Investigator
    K99HL151818     (BRUNT, VIENNA E)Jan 7, 2021 - Dec 31, 2022
    NIH
    Translational Studies of the Short-Chain Fatty Acid Acetate for Improving Age-Associated Arterial Dysfunction
    Role: Principal Investigator
    F32HL140875     (BRUNT, VIENNA E)Feb 1, 2018 - Jul 31, 2019
    NIH
    Translational studies of gut-derived trimethylamine N-oxide: a target for prevention and treatment of age-associated vascular endothelial dysfunction
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Mahoney SA, Venkatasubramanian R, Darrah MA, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Hutton DA, Brunt VE, Campisi J, Melov S, Seals DR, Rossman MJ, Clayton ZS. Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence. Aging Cell. 2024 03; 23(3):e14060. PMID: 38062873.
      View in: PubMed
    2. Clayton ZS, Rossman MJ, Mahoney SA, Venkatasubramanian R, Maurer GS, Hutton DA, VanDongen NS, Greenberg NT, Longtine AG, Ludwig KR, Brunt VE, LaRocca TJ, Campisi J, Melov S, Seals DR. Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment. Hypertension. 2023 10; 80(10):2072-2087. PMID: 37593877.
      View in: PubMed
    3. Casso AG, VanDongen NS, Gioscia-Ryan RA, Clayton ZS, Greenberg NT, Ziemba BP, Hutton DA, Neilson AP, Davy KP, Seals DR, Brunt VE. Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice. J Physiol. 2022 11; 600(21):4633-4651. PMID: 36111692.
      View in: PubMed
    4. Brunt VE, Greenberg NT, Sapinsley ZJ, Casso AG, Richey JJ, VanDongen NS, Gioscia-Ryan RA, Ziemba BP, Neilson AP, Davy KP, Seals DR. Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice. J Appl Physiol (1985). 2022 10 01; 133(4):798-813. PMID: 35952350.
      View in: PubMed
    5. Clayton ZS, Craighead DH, Darvish S, Coppock M, Ludwig KR, Brunt VE, Seals DR, Rossman MJ. Promoting healthy cardiovascular aging: emerging topics. J Cardiovasc Aging. 2022; 2. PMID: 36337728.
      View in: PubMed
    6. Brunt VE, Ikoba AP, Ziemba BP, Ballak DB, Hoischen A, Dinarello CA, Ehringer MA, Seals DR. Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs. Geroscience. 2023 02; 45(1):65-84. PMID: 35622271.
      View in: PubMed
    7. Larson EA, Ely BR, Brunt VE, Francisco MA, Harris SM, Halliwill JR, Minson CT. Brachial and carotid hemodynamic response to hot water immersion in men and women. Am J Physiol Regul Integr Comp Physiol. 2021 12 01; 321(6):R823-R832. PMID: 34643115.
      View in: PubMed
    8. Clayton ZS, Hutton DA, Brunt VE, VanDongen NS, Ziemba BP, Casso AG, Greenberg NT, Mercer AN, Rossman MJ, Campisi J, Melov S, Seals DR. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. Am J Physiol Heart Circ Physiol. 2021 07 01; 321(1):H185-H196. PMID: 34114892.
      View in: PubMed
    9. Brunt VE, Casso AG, Gioscia-Ryan RA, Sapinsley ZJ, Ziemba BP, Clayton ZS, Bazzoni AE, VanDongen NS, Richey JJ, Hutton DA, Zigler MC, Neilson AP, Davy KP, Seals DR. Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans. Hypertension. 2021 08; 78(2):499-511. PMID: 33966451.
      View in: PubMed
    10. Brunt VE, Minson CT. Heat therapy: mechanistic underpinnings and applications to cardiovascular health. J Appl Physiol (1985). 2021 06 01; 130(6):1684-1704. PMID: 33792402.
      View in: PubMed
    11. Clayton ZS, Brunt VE, Hutton DA, Casso AG, Ziemba BP, Melov S, Campisi J, Seals DR. Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin. Hypertension. 2021 05 05; 77(5):1581-1590. PMID: 33719511.
      View in: PubMed
    12. Clayton ZS, Brunt VE, Hutton DA, VanDongen NS, D'Alessandro A, Reisz JA, Ziemba BP, Seals DR. Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment. JACC CardioOncol. 2020 Sep; 2(3):475-488. PMID: 33073250.
      View in: PubMed
    13. Brunt VE, LaRocca TJ, Bazzoni AE, Sapinsley ZJ, Miyamoto-Ditmon J, Gioscia-Ryan RA, Neilson AP, Link CD, Seals DR. The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging. Geroscience. 2021 02; 43(1):377-394. PMID: 32862276.
      View in: PubMed
    14. Nguyen KH, Brunt VE. Attenuation of exaggerated blood pressure responses to exercise: a byproduct of improved vascular function with passive heat therapy? J Physiol. 2020 10; 598(20):4443-4445. PMID: 32687606.
      View in: PubMed
    15. Brunt VE, Gioscia-Ryan RA, Casso AG, VanDongen NS, Ziemba BP, Sapinsley ZJ, Richey JJ, Zigler MC, Neilson AP, Davy KP, Seals DR. Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans. Hypertension. 2020 07; 76(1):101-112. PMID: 32520619.
      View in: PubMed
    16. Casso AG, Brunt VE. Preventing endothelial cell-mediated muscle satellite cell dysfunction: a new hot topic? J Physiol. 2020 01; 598(2):225-226. PMID: 31816107.
      View in: PubMed
    17. Ballak DB, Brunt VE, Sapinsley ZJ, Ziemba BP, Richey JJ, Zigler MC, Johnson LC, Gioscia-Ryan RA, Culp-Hill R, Eisenmesser EZ, D'Alessandro A, Dinarello CA, Seals DR. Short-term interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity, and whole-body glucose metabolism in old mice. Aging Cell. 2020 01; 19(1):e13074. PMID: 31755162.
      View in: PubMed
    18. Ely BR, Francisco MA, Halliwill JR, Bryan SD, Comrada LN, Larson EA, Brunt VE, Minson CT. Heat therapy reduces sympathetic activity and improves cardiovascular risk profile in women who are obese with polycystic ovary syndrome. Am J Physiol Regul Integr Comp Physiol. 2019 11 01; 317(5):R630-R640. PMID: 31483156.
      View in: PubMed
    19. Brunt VE, Weidenfeld-Needham KM, Comrada LN, Francisco MA, Eymann TM, Minson CT. Serum from young, sedentary adults who underwent passive heat therapy improves endothelial cell angiogenesis via improved nitric oxide bioavailability. Temperature (Austin). 2019; 6(2):169-178. PMID: 31286027.
      View in: PubMed
    20. Brunt VE, Gioscia-Ryan RA, Richey JJ, Zigler MC, Cuevas LM, Gonzalez A, V?zquez-Baeza Y, Battson ML, Smithson AT, Gilley AD, Ackermann G, Neilson AP, Weir T, Davy KP, Knight R, Seals DR. Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice. J Physiol. 2019 05; 597(9):2361-2378. PMID: 30714619.
      View in: PubMed
    21. Brunt VE, Wiedenfeld-Needham K, Comrada LN, Minson CT. Passive heat therapy protects against endothelial cell hypoxia-reoxygenation via effects of elevations in temperature and circulating factors. J Physiol. 2018 10; 596(20):4831-4845. PMID: 30118148.
      View in: PubMed
    22. Seals DR, Brunt VE, Rossman MJ. Keynote lecture: strategies for optimal cardiovascular aging. Am J Physiol Heart Circ Physiol. 2018 08 01; 315(2):H183-H188. PMID: 29652545.
      View in: PubMed
    23. Rosenberg HL, Brunt VE, Rossman MJ. Diastolic dysfunction and older adults: heating up the conversation. J Physiol. 2017 08 01; 595(15):5011-5012. PMID: 28590085.
      View in: PubMed
    24. Brunt VE, Howard MJ, Francisco MA, Ely BR, Minson CT. Reply from Vienna E. Brunt, Matthew J. Howard, Michael A. Francisco, Brett R. Ely and Christopher T. Minson. J Physiol. 2017 06 01; 595(11):3669-3670. PMID: 28568770.
      View in: PubMed
    25. Francisco MA, Brunt VE, Jensen KN, Lorenzo S, Minson CT. Ten days of repeated local forearm heating does not affect cutaneous vascular function. J Appl Physiol (1985). 2017 Aug 01; 123(2):310-316. PMID: 28473615.
      View in: PubMed
    26. Brunt VE, Howard MJ, Francisco MA, Ely BR, Minson CT. Reply from Vienna E. Brunt, Matthew J. Howard, Michael A. Francisco, Brett R. Ely and Christopher T. Minson. J Physiol. 2016 12 01; 594(23):7143-7144. PMID: 27905130.
      View in: PubMed
    27. Brunt VE, Jeckell AT, Ely BR, Howard MJ, Thijssen DH, Minson CT. Acute hot water immersion is protective against impaired vascular function following forearm ischemia-reperfusion in young healthy humans. Am J Physiol Regul Integr Comp Physiol. 2016 12 01; 311(6):R1060-R1067. PMID: 27707723.
      View in: PubMed
    28. Brunt VE, Eymann TM, Francisco MA, Howard MJ, Minson CT. Passive heat therapy improves cutaneous microvascular function in sedentary humans via improved nitric oxide-dependent dilation. J Appl Physiol (1985). 2016 09 01; 121(3):716-23. PMID: 27418688.
      View in: PubMed
    29. Brunt VE, Howard MJ, Francisco MA, Ely BR, Minson CT. Passive heat therapy improves endothelial function, arterial stiffness and blood pressure in sedentary humans. J Physiol. 2016 09 15; 594(18):5329-42. PMID: 27270841.
      View in: PubMed
    30. Fujii N, Meade RD, Minson CT, Brunt VE, Boulay P, Sigal RJ, Kenny GP. Cutaneous blood flow during intradermal NO administration in young and older adults: roles for calcium-activated potassium channels and cyclooxygenase? Am J Physiol Regul Integr Comp Physiol. 2016 06 01; 310(11):R1081-7. PMID: 27053645.
      View in: PubMed
    31. Zarling JA, Brunt VE, Vallerga AK, Li W, Tao A, Zarling DA, Minson CT. Nitroxide pharmaceutical development for age-related degeneration and disease. Front Genet. 2015; 6:325. PMID: 26594225.
      View in: PubMed
    32. Brunt VE, Fujii N, Minson CT. Endothelial-derived hyperpolarization contributes to acetylcholine-mediated vasodilation in human skin in a dose-dependent manner. J Appl Physiol (1985). 2015 Nov 01; 119(9):1015-22. PMID: 26384409.
      View in: PubMed
    33. Ely BR, Brunt VE, Minson CT. Can targeting glutamate receptors with long-term heat acclimation improve outcomes following hypoxic injury? Temperature (Austin). 2015 Jan-Mar; 2(1):51-2. PMID: 27227003.
      View in: PubMed
    34. Choi PJ, Brunt VE, Fujii N, Minson CT. New approach to measure cutaneous microvascular function: an improved test of NO-mediated vasodilation by thermal hyperemia. J Appl Physiol (1985). 2014 Aug 01; 117(3):277-83. PMID: 24903917.
      View in: PubMed
    35. Fujii N, Brunt VE, Minson CT. Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers. Am J Physiol Heart Circ Physiol. 2014 Jun 01; 306(11):H1507-11. PMID: 24682395.
      View in: PubMed
    36. Brunt VE, Fujii N, Minson CT. No independent, but an interactive, role of calcium-activated potassium channels in human cutaneous active vasodilation. J Appl Physiol (1985). 2013 Nov 01; 115(9):1290-6. PMID: 23970531.
      View in: PubMed
    37. Brunt VE, Miner JA, Kaplan PF, Halliwill JR, Strycker LA, Minson CT. Short-term administration of progesterone and estradiol independently alter carotid-vasomotor, but not carotid-cardiac, baroreflex function in young women. Am J Physiol Heart Circ Physiol. 2013 Oct 01; 305(7):H1041-9. PMID: 23873800.
      View in: PubMed
    38. Fujii N, Reinke MC, Brunt VE, Minson CT. Impaired acetylcholine-induced cutaneous vasodilation in young smokers: roles of nitric oxide and prostanoids. Am J Physiol Heart Circ Physiol. 2013 Mar 01; 304(5):H667-73. PMID: 23316063.
      View in: PubMed
    39. Brunt VE, Minson CT. KCa channels and epoxyeicosatrienoic acids: major contributors to thermal hyperaemia in human skin. J Physiol. 2012 Aug 01; 590(15):3523-34. PMID: 22674719.
      View in: PubMed
    40. Miner JA, Martini ER, Smith MM, Brunt VE, Kaplan PF, Halliwill JR, Minson CT. Short-term oral progesterone administration antagonizes the effect of transdermal estradiol on endothelium-dependent vasodilation in young healthy women. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1716-22. PMID: 21856917.
      View in: PubMed
    41. Brunt VE, Miner JA, Meendering JR, Kaplan PF, Minson CT. 17?-estradiol and progesterone independently augment cutaneous thermal hyperemia but not reactive hyperemia. Microcirculation. 2011 Jul; 18(5):347-55. PMID: 21426437.
      View in: PubMed
    42. Brunt VE, Minson CT. Cutaneous thermal hyperemia: more than skin deep. J Appl Physiol (1985). 2011 Jul; 111(1):5-7. PMID: 21551016.
      View in: PubMed
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