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Patrick John Hu

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    T32GM149361     (WILSON, CARA C.)Jul 1, 2023 - Jun 30, 2028
    NIH
    Medical Scientist Training Program
    Role: Co-Principal Investigator
    R01AG041177     (HU, PATRICK J)Aug 1, 2012 - Apr 30, 2018
    NIH
    FoxO phosphorylation in the control of C. elegans lifespan
    Role: Principal Investigator
    R56DK078183     (HU, PATRICK J)Jul 15, 2008 - Dec 30, 2010
    NIH
    Novel regulators of FoxO transcription factors
    Role: Principal Investigator
    K08DK062884     (HU, PATRICK J)Jul 1, 2002 - Jun 30, 2007
    NIH
    Genetic Analysis of DAF-18/PTEN Signaling in C.elegans
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rhee KY, Emala CW, Gallagher EJ, Rockey DC, Hu PJ, Vyas JM, Cook DP, Scharschmidt TC, Ajijola OA, Williams CS. Paving the physician-scientist career path: from grassroots gathering to national forum. JCI Insight. 2025 Apr 08; 10(7). PMID: 40197362.
      View in: PubMed
    2. Lee YC, Hung MJ, Chen TH, Mao CT, Yeh CT, Kounis NG, Chen IY, Hu P, Hung MY. Effects of statins in patients with coronary artery spasm: A nationwide population-based study. Clin Transl Sci. 2024 Nov; 17(11):e70087. PMID: 39568301.
      View in: PubMed
    3. Gallagher EJ, Conlin PR, Kazmierczak BI, Vyas JM, Ajijola OA, Kontos CD, Baiocchi RA, Rhee KY, Hu PJ, Isales CM, Williams CS, Rockey DC. Is it time to reduce the length of postgraduate training for physician-scientists in internal medicine? JCI Insight. 2024 May 22; 9(10). PMID: 38775155.
      View in: PubMed
    4. Williams CS, Gallagher EJ, Rockey DC, Ajijola OA, Hu PJ, Kazmierczak BI, Kontos CD, Vyas JM, Zaidi M, Rhee KY. Structural insights into the career path between pre- and postgraduate physician-scientist training programs. Elife. 2023 10 02; 12. PMID: 37782020.
      View in: PubMed
    5. Price MJ, Boutis L, Kirtane AJ, Chetcuti S, Poliaciková P, Dens J, Attubato M, Wang Y, Hu P, Spriggs D, Krasnow J, Chatzizisis Y, Aminian A, Caputo R, Shah A, Dauler M, Ibrahim S, Lung TH, Mehran R. Three-Year Outcomes After Bifurcation Stenting With Zotarolimus-Eluting Stents: Final Results From the RESOLUTE ONYX Postapproval Study. J Soc Cardiovasc Angiogr Interv. 2023 Nov-Dec; 2(6Part A):101116. PMID: 39129891.
      View in: PubMed
    6. Hung MJ, Yeh CT, Kounis NG, Koniari I, Hu P, Hung MY. Coronary Artery Spasm-Related Heart Failure Syndrome: Literature Review. Int J Mol Sci. 2023 Apr 19; 24(8). PMID: 37108691.
      View in: PubMed
    7. Gallagher EJ, Rockey DC, Kontos CD, Vyas JM, Brass LF, Hu PJ, Isales CM, Ajijola OA, Rathmell WK, Conlin PR, Baiocchi RA, Kazmierczak BI, Akabas MH, Williams CS. Pearls of wisdom for aspiring physician-scientist residency applicants and program directors. JCI Insight. 2022 03 22; 7(6). PMID: 35315364.
      View in: PubMed
    8. Lin YK, Yeh CT, Kuo KT, Fong IH, Yadav VK, Kounis NG, Hu P, Hung MY. Apolipoprotein (a)/Lipoprotein(a)-Induced Oxidative-Inflammatory a7-nAChR/p38 MAPK/IL-6/RhoA-GTP Signaling Axis and M1 Macrophage Polarization Modulate Inflammation-Associated Development of Coronary Artery Spasm. Oxid Med Cell Longev. 2022; 2022:9964689. PMID: 35096275.
      View in: PubMed
    9. Lin YK, Yeh CT, Kuo KT, Yadav VK, Fong IH, Kounis NG, Hu P, Hung MY. Pterostilbene Increases LDL Metabolism in HL-1 Cardiomyocytes by Modulating the PCSK9/HNF1a/SREBP2/LDLR Signaling Cascade, Upregulating Epigenetic hsa-miR-335 and hsa-miR-6825, and LDL Receptor Expression. Antioxidants (Basel). 2021 Aug 12; 10(8). PMID: 34439528.
      View in: PubMed
    10. Hu PJ. Microbiome: Insulin signaling shapes gut community composition. Curr Biol. 2021 06 21; 31(12):R803-R806. PMID: 34157268.
      View in: PubMed
    11. Hung MJ, Chang NC, Hu P, Chen TH, Mao CT, Yeh CT, Hung MY. Association between Coronary Artery Spasm and the risk of incident Diabetes: A Nationwide population-based Cohort Study. Int J Med Sci. 2021; 18(12):2630-2640. PMID: 34104095.
      View in: PubMed
    12. Chang NC, Yeh CT, Lin YK, Kuo KT, Fong IH, Kounis NG, Hu P, Hung MY. Garcinol Attenuates Lipoprotein(a)-Induced Oxidative Stress and Inflammatory Cytokine Production in Ventricular Cardiomyocyte through a7-Nicotinic Acetylcholine Receptor-Mediated Inhibition of the p38 MAPK and NF-?B Signaling Pathways. Antioxidants (Basel). 2021 Mar 16; 10(3). PMID: 33809417.
      View in: PubMed
    13. Baugh LR, Hu PJ. Starvation Responses Throughout the Caenorhabditiselegans Life Cycle. Genetics. 2020 12; 216(4):837-878. PMID: 33268389.
      View in: PubMed
    14. Le HH, Wrobel CJ, Cohen SM, Yu J, Park H, Helf MJ, Curtis BJ, Kruempel JC, Rodrigues PR, Hu PJ, Sternberg PW, Schroeder FC. Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles. Elife. 2020 10 16; 9. PMID: 33063667.
      View in: PubMed
    15. Hung MY, Kounis NG, Lu MY, Hu P. Myocardial Ischemic Syndromes, Heart Failure Syndromes, Electrocardiographic Abnormalities, Arrhythmic Syndromes and Angiographic Diagnosis of Coronary Artery Spasm: Literature Review. Int J Med Sci. 2020; 17(8):1071-1082. PMID: 32410837.
      View in: PubMed
    16. Permar SR, Ward RA, Barrett KJ, Freel SA, Gbadegesin RA, Kontos CD, Hu PJ, Hartmann KE, Williams CS, Vyas JM. Addressing the physician-scientist pipeline: strategies to integrate research into clinical training programs. J Clin Invest. 2020 03 02; 130(3):1058-1061. PMID: 32039914.
      View in: PubMed
    17. Chang NC, Hu P, Chen TH, Mao CT, Hung MJ, Yeh CT, Hung MY. Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study. PLoS One. 2020; 15(1):e0227571. PMID: 31923246.
      View in: PubMed
    18. Li X, Itani OA, Haataja L, Dumas KJ, Yang J, Cha J, Flibotte S, Shih HJ, Delaney CE, Xu J, Qi L, Arvan P, Liu M, Hu PJ. Requirement for translocon-associated protein (TRAP) a in insulin biogenesis. Sci Adv. 2019 12; 5(12):eaax0292. PMID: 31840061.
      View in: PubMed
    19. Hung MY, Mao CT, Hung MJ, Wang JK, Lee HC, Yeh CT, Hu P, Chen TH, Chang NC. Coronary Artery Spasm as Related to Anxiety and Depression: A Nationwide Population-Based Study. Psychosom Med. 2019 04; 81(3):237-245. PMID: 30652987.
      View in: PubMed
    20. Williams CS, Iness AN, Baron RM, Ajijola OA, Hu PJ, Vyas JM, Baiocchi R, Adami AJ, Lever JM, Klein PS, Demer L, Madaio M, Geraci M, Brass LF, Blanchard M, Salata R, Zaidi M. Training the physician-scientist: views from program directors and aspiring young investigators. JCI Insight. 2018 12 06; 3(23). PMID: 30518696.
      View in: PubMed
    21. Hung MY, Wu YH, Bamodu OA, Chen X, Lin YK, Hu P, Chang NC, Pang JS, Yeh CT. Activation of the monocytic a7 nicotinic acetylcholine receptor modulates oxidative stress and inflammation-associated development of coronary artery spasm via a p38 MAP-kinase signaling-dependent pathway. Free Radic Biol Med. 2018 05 20; 120:266-276. PMID: 29609021.
      View in: PubMed
    22. Delaney CE, Chen AT, Graniel JV, Dumas KJ, Hu PJ. A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity. Development. 2017 04 01; 144(7):1273-1282. PMID: 28209779.
      View in: PubMed
    23. Itani OA, Flibotte S, Dumas KJ, Guo C, Blumenthal T, Hu PJ. N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3' Splice Site Function in Vivo. G3 (Bethesda). 2016 06 01; 6(6):1751-6. PMID: 27172199; PMCID: PMC4889670.
      View in: PubMed, PubMed Central
    24. Itani OA, Flibotte S, Dumas KJ, Moerman DG, Hu PJ. Chromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans. G3 (Bethesda). 2015 Dec 01; 6(2):351-6. PMID: 26628482.
      View in: PubMed
    25. Chen AT, Guo C, Itani OA, Budaitis BG, Williams TW, Hopkins CE, McEachin RC, Pande M, Grant AR, Yoshina S, Mitani S, Hu PJ. Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans. Genetics. 2015 Oct; 201(2):613-29. PMID: 26219299.
      View in: PubMed
    26. Hung MJ, Hu P, Hung MY. Coronary artery spasm: review and update. Int J Med Sci. 2014; 11(11):1161-71. PMID: 25249785.
      View in: PubMed
    27. Hu PJ. Whole genome sequencing and the transformation of C. elegans forward genetics. Methods. 2014 Aug 01; 68(3):437-40. PMID: 24874788.
      View in: PubMed
    28. Mahanti P, Bose N, Bethke A, Judkins JC, Wollam J, Dumas KJ, Zimmerman AM, Campbell SL, Hu PJ, Antebi A, Schroeder FC. Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan. Cell Metab. 2014 Jan 07; 19(1):73-83. PMID: 24411940.
      View in: PubMed
    29. Murphy CT, Hu PJ. Insulin/insulin-like growth factor signaling in C. elegans. WormBook. 2013 Dec 26; 1-43. PMID: 24395814.
      View in: PubMed
    30. Ferguson AA, Roy S, Kormanik KN, Kim Y, Dumas KJ, Ritov VB, Matern D, Hu PJ, Fisher AL. TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans. PLoS Genet. 2013; 9(12):e1004020. PMID: 24385923.
      View in: PubMed
    31. Chen AT, Guo C, Dumas KJ, Ashrafi K, Hu PJ. Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation. Aging Cell. 2013 Oct; 12(5):932-40. PMID: 23786484.
      View in: PubMed
    32. Dumas KJ, Delaney CE, Flibotte S, Moerman DG, Csankovszki G, Hu PJ. Unexpected role for dosage compensation in the control of dauer arrest, insulin-like signaling, and FoxO transcription factor activity in Caenorhabditis elegans. Genetics. 2013 Jul; 194(3):619-29. PMID: 23733789.
      View in: PubMed
    33. Dumas KJ, Guo C, Shih HJ, Hu PJ. Influence of steroid hormone signaling on life span control by Caenorhabditis elegans insulin-like signaling. G3 (Bethesda). 2013 May 20; 3(5):841-50. PMID: 23550118.
      View in: PubMed
    34. Hu PJ, Knoepp SM, Wu R, Cho KR. Ovarian steroid cell tumor with biallelic adenomatous polyposis coli inactivation in a patient with familial adenomatous polyposis. Genes Chromosomes Cancer. 2012 Mar; 51(3):283-9. PMID: 22120905.
      View in: PubMed
    35. Williams TW, Dumas KJ, Hu PJ. EAK proteins: novel conserved regulators of C. elegans lifespan. Aging (Albany NY). 2010 Oct; 2(10):742-7. PMID: 20975207.
      View in: PubMed
    36. Alam H, Williams TW, Dumas KJ, Guo C, Yoshina S, Mitani S, Hu PJ. EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. Cell Metab. 2010 Jul 07; 12(1):30-41. PMID: 20620993.
      View in: PubMed
    37. Dumas KJ, Guo C, Wang X, Burkhart KB, Adams EJ, Alam H, Hu PJ. Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan. Dev Biol. 2010 Apr 15; 340(2):605-12. PMID: 20178781.
      View in: PubMed
    38. Hu PJ, Sherman DH. DANSing with Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7685-6. PMID: 19416852.
      View in: PubMed
    39. Zhang Y, Xu J, Puscau C, Kim Y, Wang X, Alam H, Hu PJ. Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity. Dev Biol. 2008 Mar 15; 315(2):290-302. PMID: 18241854.
      View in: PubMed
    40. Hu PJ. Dauer. WormBook. 2007 Aug 08; 1-19. PMID: 17988074.
      View in: PubMed
    41. Hu PJ, Xu J, Ruvkun G. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006 Jul; 2(7):e99. PMID: 16839187.
      View in: PubMed
    42. Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Mol Cell. 2004 Feb 27; 13(4):469-82. PMID: 14992718.
      View in: PubMed
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