 Adrenoleukodystrophy
"Adrenoleukodystrophy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An X-linked recessive disorder characterized by the accumulation of saturated very long chain fatty acids in the LYSOSOMES of ADRENAL CORTEX and the white matter of CENTRAL NERVOUS SYSTEM. This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS).
| Descriptor ID |
D000326
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| MeSH Number(s) |
C10.228.140.163.100.084 C10.228.140.163.100.362.250 C10.228.140.695.625.250 C10.314.400.250 C10.597.606.643.455.124 C16.320.322.500.124 C16.320.400.525.124 C16.320.565.189.084 C16.320.565.189.362.250 C16.320.565.663.100 C18.452.132.100.084 C18.452.132.100.362.250 C18.452.648.189.084 C18.452.648.189.362.250 C18.452.648.663.100 C19.053.500.270
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| Concept/Terms |
Adrenoleukodystrophy- Adrenoleukodystrophy
- Melanodermic Leukodystrophy
- Leukodystrophies, Melanodermic
- Leukodystrophy, Melanodermic
- Siemerling-Creutzfeldt Disease
- Siemerling Creutzfeldt Disease
- Addison Disease and Cerebral Sclerosis
- X-ALD
- X ALD
- Bronze Schilder Disease
- X-Linked Adrenoleukodystrophy
- Adrenoleukodystrophy, X-Linked
- X Linked Adrenoleukodystrophy
- ALD (Adrenoleukodystrophy)
- X-ALD (X-Linked Adrenoleukodystrophy)
- X ALD (X Linked Adrenoleukodystrophy)
- Schilder-Addison Complex
- Schilder Addison Complex
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Below are MeSH descriptors whose meaning is more general than "Adrenoleukodystrophy".
- Diseases [C]
- Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Brain Diseases, Metabolic [C10.228.140.163]
- Brain Diseases, Metabolic, Inborn [C10.228.140.163.100]
- Adrenoleukodystrophy [C10.228.140.163.100.084]
- Hereditary Central Nervous System Demyelinating Diseases [C10.228.140.163.100.362]
- Adrenoleukodystrophy [C10.228.140.163.100.362.250]
- Leukoencephalopathies [C10.228.140.695]
- Hereditary Central Nervous System Demyelinating Diseases [C10.228.140.695.625]
- Adrenoleukodystrophy [C10.228.140.695.625.250]
- Demyelinating Diseases [C10.314]
- Hereditary Central Nervous System Demyelinating Diseases [C10.314.400]
- Adrenoleukodystrophy [C10.314.400.250]
- Neurologic Manifestations [C10.597]
- Neurobehavioral Manifestations [C10.597.606]
- Intellectual Disability [C10.597.606.643]
- Mental Retardation, X-Linked [C10.597.606.643.455]
- Adrenoleukodystrophy [C10.597.606.643.455.124]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
- Genetic Diseases, X-Linked [C16.320.322]
- Mental Retardation, X-Linked [C16.320.322.500]
- Adrenoleukodystrophy [C16.320.322.500.124]
- Heredodegenerative Disorders, Nervous System [C16.320.400]
- Mental Retardation, X-Linked [C16.320.400.525]
- Adrenoleukodystrophy [C16.320.400.525.124]
- Metabolism, Inborn Errors [C16.320.565]
- Brain Diseases, Metabolic, Inborn [C16.320.565.189]
- Adrenoleukodystrophy [C16.320.565.189.084]
- Hereditary Central Nervous System Demyelinating Diseases [C16.320.565.189.362]
- Adrenoleukodystrophy [C16.320.565.189.362.250]
- Peroxisomal Disorders [C16.320.565.663]
- Adrenoleukodystrophy [C16.320.565.663.100]
- Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
- Brain Diseases, Metabolic [C18.452.132]
- Brain Diseases, Metabolic, Inborn [C18.452.132.100]
- Adrenoleukodystrophy [C18.452.132.100.084]
- Hereditary Central Nervous System Demyelinating Diseases [C18.452.132.100.362]
- Adrenoleukodystrophy [C18.452.132.100.362.250]
- Metabolism, Inborn Errors [C18.452.648]
- Brain Diseases, Metabolic, Inborn [C18.452.648.189]
- Adrenoleukodystrophy [C18.452.648.189.084]
- Hereditary Central Nervous System Demyelinating Diseases [C18.452.648.189.362]
- Adrenoleukodystrophy [C18.452.648.189.362.250]
- Peroxisomal Disorders [C18.452.648.663]
- Adrenoleukodystrophy [C18.452.648.663.100]
- Endocrine System Diseases [C19]
- Adrenal Gland Diseases [C19.053]
- Adrenal Insufficiency [C19.053.500]
- Adrenoleukodystrophy [C19.053.500.270]
Below are MeSH descriptors whose meaning is more specific than "Adrenoleukodystrophy".
This graph shows the total number of publications written about "Adrenoleukodystrophy" by people in this website by year, and whether "Adrenoleukodystrophy" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Adrenoleukodystrophy" by people in Profiles.
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Lauer A, Speroni SL, Choi M, Da X, Duncan C, McCarthy S, Krishnan V, Lusk CA, Rohde D, Hansen MB, Kalpathy-Cramer J, Loes DJ, Caruso PA, Williams DA, Mouridsen K, Emblem KE, Eichler FS, Musolino PL. Hematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy. Nat Commun. 2023 04 05; 14(1):1900.
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Carlson AM, Huffnagel IC, Verrips A, van der Knaap MS, Engelen M, Van Haren K. Five men with arresting and relapsing cerebral adrenoleukodystrophy. J Neurol. 2021 Mar; 268(3):936-940.
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Lauer A, Da X, Hansen MB, Boulouis G, Ou Y, Cai X, Liberato Celso Pedrotti A, Kalpathy-Cramer J, Caruso P, Hayden DL, Rost N, Mouridsen K, Eichler FS, Rosen B, Musolino PL. ABCD1 dysfunction alters white matter microvascular perfusion. Brain. 2017 Dec 01; 140(12):3139-3152.
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Ievers CE, Brown RT, McCandless SE, Devine DE. Case studies: psychological test findings for two children with X-linked adrenoleukodystrophy. J Dev Behav Pediatr. 1999 Feb; 20(1):31-5.
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