 Alexander Disease
"Alexander Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.
| Descriptor ID |
D038261
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| MeSH Number(s) |
C10.228.140.163.100.362.312 C10.228.140.695.625.312 C10.314.400.312 C10.574.500.024 C16.320.400.024 C16.320.565.189.362.312 C18.452.132.100.362.312 C18.452.648.189.362.312
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| Concept/Terms |
Alexander Disease- Alexander Disease
- Demyelinogenic Leukodystrophy
- Fibrinoid Degeneration of Astrocytes
- Leukodystrophy with Rosenthal Fibers
- Alexander's Disease
- Alexanders Disease
- Dysmyelinogenic Leukodystrophy
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Below are MeSH descriptors whose meaning is more general than "Alexander Disease".
- Diseases [C]
- Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Brain Diseases, Metabolic [C10.228.140.163]
- Brain Diseases, Metabolic, Inborn [C10.228.140.163.100]
- Hereditary Central Nervous System Demyelinating Diseases [C10.228.140.163.100.362]
- Alexander Disease [C10.228.140.163.100.362.312]
- Leukoencephalopathies [C10.228.140.695]
- Hereditary Central Nervous System Demyelinating Diseases [C10.228.140.695.625]
- Alexander Disease [C10.228.140.695.625.312]
- Demyelinating Diseases [C10.314]
- Hereditary Central Nervous System Demyelinating Diseases [C10.314.400]
- Alexander Disease [C10.314.400.312]
- Neurodegenerative Diseases [C10.574]
- Heredodegenerative Disorders, Nervous System [C10.574.500]
- Alexander Disease [C10.574.500.024]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
- Heredodegenerative Disorders, Nervous System [C16.320.400]
- Alexander Disease [C16.320.400.024]
- Metabolism, Inborn Errors [C16.320.565]
- Brain Diseases, Metabolic, Inborn [C16.320.565.189]
- Hereditary Central Nervous System Demyelinating Diseases [C16.320.565.189.362]
- Alexander Disease [C16.320.565.189.362.312]
- Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
- Brain Diseases, Metabolic [C18.452.132]
- Brain Diseases, Metabolic, Inborn [C18.452.132.100]
- Hereditary Central Nervous System Demyelinating Diseases [C18.452.132.100.362]
- Alexander Disease [C18.452.132.100.362.312]
- Metabolism, Inborn Errors [C18.452.648]
- Brain Diseases, Metabolic, Inborn [C18.452.648.189]
- Hereditary Central Nervous System Demyelinating Diseases [C18.452.648.189.362]
- Alexander Disease [C18.452.648.189.362.312]
Below are MeSH descriptors whose meaning is more specific than "Alexander Disease".
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