 Pyridoxal Phosphate
"Pyridoxal Phosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
| Descriptor ID |
D011732
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| MeSH Number(s) |
D03.383.725.676.925.500.500 D08.211.740
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| Concept/Terms |
Pyridoxal Phosphate- Pyridoxal Phosphate
- Phosphate, Pyridoxal
- Pyridoxal-P
- Pyridoxal P
- Pyridoxal 5-Phosphate
- Pyridoxal 5 Phosphate
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Below are MeSH descriptors whose meaning is more general than "Pyridoxal Phosphate".
Below are MeSH descriptors whose meaning is more specific than "Pyridoxal Phosphate".
This graph shows the total number of publications written about "Pyridoxal Phosphate" by people in this website by year, and whether "Pyridoxal Phosphate" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 2 | 1 | 3 | | 2011 | 0 | 2 | 2 | | 2012 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "Pyridoxal Phosphate" by people in Profiles.
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Kim J, Flood JJ, Kristofich MR, Gidfar C, Morgenthaler AB, Fuhrer T, Sauer U, Snyder D, Cooper VS, Ebmeier CC, Old WM, Copley SD. Hidden resources in the Escherichia coli genome restore PLP synthesis and robust growth after deletion of the essential gene pdxB. Proc Natl Acad Sci U S A. 2019 11 26; 116(48):24164-24173.
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Johnstone DL, Al-Shekaili HH, Tarailo-Graovac M, Wolf NI, Ivy AS, Demarest S, Roussel Y, Ciapaite J, van Roermund CWT, Kernohan KD, Kosuta C, Ban K, Ito Y, McBride S, Al-Thihli K, Abdelrahim RA, Koul R, Al Futaisi A, Haaxma CA, Olson H, Sigurdardottir LY, Arnold GL, Gerkes EH, Boon M, Heiner-Fokkema MR, Noble S, Bosma M, Jans J, Koolen DA, Kamsteeg EJ, Dr?gem?ller B, Ross CJ, Majewski J, Cho MT, Begtrup A, Wasserman WW, Bui T, Brimble E, Violante S, Houten SM, Wevers RA, van Faassen M, Kema IP, Lepage N, Lines MA, Dyment DA, Wanders RJA, Verhoeven-Duif N, Ekker M, Boycott KM, Friedman JM, Pena IA, van Karnebeek CDM. PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights. Brain. 2019 03 01; 142(3):542-559.
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Lee M, Sousa MC. Structural basis for substrate specificity in ArnB. A key enzyme in the polymyxin resistance pathway of Gram-negative bacteria. Biochemistry. 2014 Feb 04; 53(4):796-805.
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Kim J, Copley SD. Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):E2856-64.
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Smith AT, Su Y, Stevens DJ, Majtan T, Kraus JP, Burstyn JN. Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine ?-synthase. Biochemistry. 2012 Aug 14; 51(32):6360-70.
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MacFarlane AJ, Anderson DD, Flodby P, Perry CA, Allen RH, Stabler SP, Stover PJ. Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA. J Biol Chem. 2011 Dec 23; 286(51):44015-44022.
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Benight NM, Stoll B, Chacko S, da Silva VR, Marini JC, Gregory JF, Stabler SP, Burrin DG. B-vitamin deficiency is protective against DSS-induced colitis in mice. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G249-59.
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Smith AT, Majtan T, Freeman KM, Su Y, Kraus JP, Burstyn JN. Cobalt cystathionine ?-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif. Inorg Chem. 2011 May 16; 50(10):4417-27.
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Kim J, Kershner JP, Novikov Y, Shoemaker RK, Copley SD. Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis. Mol Syst Biol. 2010 Nov 30; 6:436.
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Rudolph J, Kim J, Copley SD. Multiple turnovers of the nicotino-enzyme PdxB require a-keto acids as cosubstrates. Biochemistry. 2010 Nov 02; 49(43):9249-55.
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