 Thioctic Acid
"Thioctic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Descriptor ID |
D008063
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| MeSH Number(s) |
D02.241.803 D02.886.778.827 D08.211.906 D10.251.941
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| Concept/Terms |
Thioctic Acid- Thioctic Acid
- alpha-Lipoic Acid
- Acid, alpha-Lipoic
- alpha Lipoic Acid
- Lipoic Acid
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Below are MeSH descriptors whose meaning is more general than "Thioctic Acid".
Below are MeSH descriptors whose meaning is more specific than "Thioctic Acid".
This graph shows the total number of publications written about "Thioctic Acid" by people in this website by year, and whether "Thioctic Acid" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2013 | 2 | 0 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Thioctic Acid" by people in Profiles.
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Joksimovic SL, Lamborn N, Jevtovic-Todorovic V, Todorovic SM. Alpha lipoic acid attenuates evoked and spontaneous pain following surgical skin incision in rats. Channels (Austin). 2021 12; 15(1):398-407.
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Plaks JG, Falatach R, Kastantin M, Berberich JA, Kaar JL. Multisite clickable modification of proteins using lipoic acid ligase. Bioconjug Chem. 2015 Jun 17; 26(6):1104-12.
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Shinto L, Quinn J, Montine T, Dodge HH, Woodward W, Baldauf-Wagner S, Waichunas D, Bumgarner L, Bourdette D, Silbert L, Kaye J. A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease. J Alzheimers Dis. 2014; 38(1):111-20.
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Todorovic SM, Jevtovic-Todorovic V. Redox regulation of neuronal voltage-gated calcium channels. Antioxid Redox Signal. 2014 Aug 20; 21(6):880-91.
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Rossman MJ, Groot HJ, Reese V, Zhao J, Amann M, Richardson RS. Oxidative stress and COPD: the effect of oral antioxidants on skeletal muscle fatigue. Med Sci Sports Exerc. 2013 Jul; 45(7):1235-43.
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Falkard B, Kumar TR, Hecht LS, Matthews KA, Henrich PP, Gulati S, Lewis RE, Manary MJ, Winzeler EA, Sinnis P, Prigge ST, Heussler V, Deschermeier C, Fidock D. A key role for lipoic acid synthesis during Plasmodium liver stage development. Cell Microbiol. 2013 Sep; 15(9):1585-604.
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Kumazaki M, Ando H, Kakei M, Ushijima K, Taniguchi Y, Yoshida M, Yamato S, Washino S, Koshimizu TA, Fujimura A. a-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs. Eur J Pharmacol. 2013 Apr 05; 705(1-3):1-10.
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Lee WY, Orestes P, Latham J, Naik AK, Nelson MT, Vitko I, Perez-Reyes E, Jevtovic-Todorovic V, Todorovic SM. Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway. J Neurosci. 2009 Jul 29; 29(30):9500-9.
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Stabler SP, Sekhar J, Allen RH, O'Neill HC, White CW. Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine. Free Radic Biol Med. 2009 Oct 15; 47(8):1147-53.
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O'Neill HC, Rancourt RC, White CW. Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH. Antioxid Redox Signal. 2008 Feb; 10(2):277-85.
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