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Michael Stowell

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
Phone303/735-2983

    Collapse Research 
    Collapse research activities and funding
    U24GM139174     (HOENGER, ANDREAS ;LUGER, KAROLIN ;STOWELL, MICHAEL H. B.)Sep 8, 2020 - Aug 31, 2024
    NIH
    CU Boulder Center for Cryo-ET (CCET)
    Role: Co-Principal Investigator
    RF1AG061829     (SHEN, JINGSHI)Sep 30, 2018 - Mar 31, 2023
    NIH
    Identifying exosome-mediated cargo transport machinery in Alzheimer's disease
    Role: Co-Principal Investigator
    U24GM116789     (JIANG, WEN)Jun 1, 2017 - May 31, 2022
    NIH
    Midwest Consortium for High Resolution Cryoelectron Microscopy
    Role: Co-Principal Investigator
    R01GM114496     (STOWELL, MICHAEL H. B.)Sep 10, 2015 - Aug 31, 2017
    NIH
    Membrane Protein Polyhedral Nanoparticles for High Resolution Structure/Function Studies
    Role: Principal Investigator
    R43MH102946     (LINNENBERGER, ANNA)Sep 4, 2014 - Aug 31, 2016
    NIH
    3D living neural networks
    Role: Co-Principal Investigator
    U54GM094610     (REES, DOUGLAS CHARLES)Sep 30, 2010 - Jun 30, 2015
    NIH
    TransportPDB: Center for the X-ray Structure Determination of Human Transporters
    Role: Co-Principal Investigator
    R01GM085398     (STOWELL, MICHAEL H. B.)Aug 1, 2008 - Jul 31, 2011
    NIH
    Self Assembled Lipid Icosohedra for Highthroughput Membrane Protein Structure Det
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bhattacharjee B, Rahman MM, Hibbs RE, Stowell MHB. A simple flash and freeze system for cryogenic time-resolved electron microscopy. Front Mol Biosci. 2023; 10:1129225. PMID: 36959978.
      View in: PubMed
    2. Wan C, Stowell MHB, Shen J. Progress and gaps of extracellular vesicle-mediated intercellular cargo transfer in the central nervous system. Commun Biol. 2022 Nov 11; 5(1):1223. PMID: 36369335.
      View in: PubMed
    3. Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E. Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun. 2022 09 23; 13(1):5594. PMID: 36151101.
      View in: PubMed
    4. Guard SE, Chapnick DA, Poss ZC, Ebmeier CC, Jacobsen J, Nemkov T, Ball KA, Webb KJ, Simpson HL, Coleman S, Bunker E, Ramirez A, Reisz JA, Sievers R, Stowell MHB, D'Alessandro A, Liu X, Old WM. Multiomic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell Lines. Mol Cell Proteomics. 2022 Oct; 21(10):100262. PMID: 35753663.
      View in: PubMed
    5. Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC. Synergistic activation of the insulin receptor via two distinct sites. Nat Struct Mol Biol. 2022 04; 29(4):357-368. PMID: 35361965.
      View in: PubMed
    6. Rahman MM, Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE. Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nat Struct Mol Biol. 2022 04; 29(4):386-394. PMID: 35301478.
      View in: PubMed
    7. Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson DW, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP. Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. Cell. 2022 04 14; 185(8):1346-1355.e15. PMID: 35247328.
      View in: PubMed
    8. Basta T, Morgan GP, O'Toole ET, Rao NR, Savas JN, Stowell MHB. Electron Tomographic Methods for Studying Organelles of the Murine Chemical Synapse. Methods Mol Biol. 2022; 2473:129-139. PMID: 35819763.
      View in: PubMed
    9. White DN, Stowell MHB. Room for Two: The Synaptophysin/Synaptobrevin Complex. Front Synaptic Neurosci. 2021; 13:740318. PMID: 34616284.
      View in: PubMed
    10. Rahman MM, Worrell BT, Stowell MHB, Hibbs RE. Purification of a native nicotinic receptor. Methods Enzymol. 2021; 653:189-206. PMID: 34099171.
      View in: PubMed
    11. Liu Y, Wan C, Rathore SS, Stowell MHB, Yu H, Shen J. SNARE Zippering Is Suppressed by a Conformational Constraint that Is Removed by v-SNARE Splitting. Cell Rep. 2021 01 12; 34(2):108611. PMID: 33440145.
      View in: PubMed
    12. Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, Ali L, Saito T, Guillermier C, Saido TC, Steinhauser ML, Stowell MHB, Chapman ER, Contractor A, Savas JN. Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals. Cell Syst. 2021 02 17; 12(2):141-158.e9. PMID: 33326751.
      View in: PubMed
    13. Ding Y, Ball KA, Webb KJ, Gao Y, D'Alessandro A, Old WM, Stowell MHB, Ding X. On-Chip Acousto Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability. Small. 2020 10; 16(41):e2003506. PMID: 32893496.
      View in: PubMed
    14. Rahman MM, Teng J, Worrell BT, Noviello CM, Lee M, Karlin A, Stowell MHB, Hibbs RE. Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins. Neuron. 2020 06 17; 106(6):952-962.e5. PMID: 32275860.
      View in: PubMed
    15. Ball KA, Webb KJ, Coleman SJ, Cozzolino KA, Jacobsen J, Jones KR, Stowell MHB, Old WM. An isothermal shift assay for proteome scale drug-target identification. Commun Biol. 2020 02 14; 3(1):75. PMID: 32060372.
      View in: PubMed
    16. Rathore SS, Liu Y, Yu H, Wan C, Lee M, Yin Q, Stowell MHB, Shen J. Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE. Cell Rep. 2019 12 24; 29(13):4583-4592.e3. PMID: 31875562.
      View in: PubMed
    17. Miles M, Bhattacharjee B, Sridhar N, Fajrial AK, Ball K, Lee YC, Stowell MHB, Old WM, Ding X. Flattening of Diluted Species Profile via Passive Geometry in a Microfluidic Device. Micromachines (Basel). 2019 Nov 30; 10(12). PMID: 31801276.
      View in: PubMed
    18. Ruhl DA, Bomba-Warczak E, Watson ET, Bradberry MM, Peterson TA, Basu T, Frelka A, Evans CS, Briguglio JS, Basta T, Stowell MHB, Savas JN, Roopra A, Pearce RA, Piper RC, Chapman ER. Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways. Nat Commun. 2019 08 06; 10(1):3532. PMID: 31387992.
      View in: PubMed
    19. Maity K, Heumann JM, McGrath AP, Kopcho NJ, Hsu PK, Lee CW, Mapes JH, Garza D, Krishnan S, Morgan GP, Hendargo KJ, Klose T, Rees SD, Medrano-Soto A, Saier MH, Pi?eros M, Komives EA, Schroeder JI, Chang G, Stowell MHB. Cryo-EM structure of OSCA1.2 from Oryza sativa elucidates the mechanical basis of potential membrane hyperosmolality gating. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):14309-14318. PMID: 31227607.
      View in: PubMed
    20. Janas T, Sapon K, Stowell MHB, Janas T. Selection of Membrane RNA Aptamers to Amyloid Beta Peptide: Implications for Exosome-Based Antioxidant Strategies. Int J Mol Sci. 2019 Jan 13; 20(2). PMID: 30642129.
      View in: PubMed
    21. Yu H, Crisman L, Stowell MHB, Shen J. Functional Reconstitution of Intracellular Vesicle Fusion Using Purified SNAREs and Sec1/Munc18 (SM) Proteins. Methods Mol Biol. 2019; 1860:237-249. PMID: 30317509.
      View in: PubMed
    22. Shen C, Liu Y, Yu H, Gulbranson DR, Kogut I, Bilousova G, Zhang C, Stowell MHB, Shen J. The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis. J Biol Chem. 2018 11 23; 293(47):18309-18317. PMID: 30275014.
      View in: PubMed
    23. Yu H, Shen C, Liu Y, Menasche BL, Ouyang Y, Stowell MHB, Shen J. SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8421-E8429. PMID: 30127032.
      View in: PubMed
    24. Adams DJ, Nemkov TG, Mayer JP, Old WM, Stowell MHB. Identification of the primary peptide contaminant that inhibits fibrillation and toxicity in synthetic amyloid-?42. PLoS One. 2017; 12(8):e0182804. PMID: 28792968.
      View in: PubMed
    25. Janas AM, Sapon K, Janas T, Stowell MH, Janas T. Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases. Biochim Biophys Acta. 2016 Jun; 1858(6):1139-51. PMID: 26874206.
      View in: PubMed
    26. Yu H, Rathore SS, Shen C, Liu Y, Ouyang Y, Stowell MH, Shen J. Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding. J Am Chem Soc. 2015 Oct 14; 137(40):12873-83. PMID: 26431309.
      View in: PubMed
    27. Adams DJ, Arthur CP, Stowell MH. Architecture of the Synaptophysin/Synaptobrevin Complex: Structural Evidence for an Entropic Clustering Function at the Synapse. Sci Rep. 2015 Sep 03; 5:13659. PMID: 26333660.
      View in: PubMed
    28. Basta T, Wu HJ, Morphew MK, Lee J, Ghosh N, Lai J, Heumann JM, Wang K, Lee YC, Rees DC, Stowell MH. Self-assembled lipid and membrane protein polyhedral nanoparticles. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):670-4. PMID: 24379376.
      View in: PubMed
    29. Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, Stroud RM, Stevens RC, Sali A. Coordinating the impact of structural genomics on the human a-helical transmembrane proteome. Nat Struct Mol Biol. 2013 Feb; 20(2):135-8. PMID: 23381628.
      View in: PubMed
    30. Sheng JR, Grimme S, Bhattacharya P, Stowell MH, Artinger M, Prabahakar BS, Meriggioli MN. In vivo adsorption of autoantibodies in myasthenia gravis using Nanodisc-incorporated acetylcholine receptor. Exp Neurol. 2010 Oct; 225(2):320-7. PMID: 20637753.
      View in: PubMed
    31. Arthur CP, Dean C, Pagratis M, Chapman ER, Stowell MH. Loss of synaptotagmin IV results in a reduction in synaptic vesicles and a distortion of the Golgi structure in cultured hippocampal neurons. Neuroscience. 2010 Apr 28; 167(1):135-42. PMID: 20138128.
      View in: PubMed
    32. Arthur CP, Stowell MH. Structure of synaptophysin: a hexameric MARVEL-domain channel protein. Structure. 2007 Jun; 15(6):707-14. PMID: 17562317.
      View in: PubMed
    33. Arthur CP, Serrell DB, Pagratis M, Potter DL, Finch DS, Stowell MH. Electron tomographic methods for studying the chemical synapse. Methods Cell Biol. 2007; 79:241-57. PMID: 17327160.
      View in: PubMed
    34. Yeh AP, McMillan A, Stowell MH. Rapid and simple protein-stability screens: application to membrane proteins. Acta Crystallogr D Biol Crystallogr. 2006 Apr; 62(Pt 4):451-7. PMID: 16552147.
      View in: PubMed
    35. Tierney ML, Osborn KE, Milburn PJ, Stowell MH, Howitt SM. Phylogenetic conservation of disulfide-linked, dimeric acetylcholine receptor pentamers in southern ocean electric rays. J Exp Biol. 2004 Sep; 207(Pt 20):3581-90. PMID: 15339954.
      View in: PubMed
    36. Marks B, Stowell MH, Vallis Y, Mills IG, Gibson A, Hopkins CR, McMahon HT. GTPase activity of dynamin and resulting conformation change are essential for endocytosis. Nature. 2001 Mar 08; 410(6825):231-5. PMID: 11242086.
      View in: PubMed
    37. Miyazawa A, Fujiyoshi Y, Stowell M, Unwin N. Nicotinic acetylcholine receptor at 4.6 A resolution: transverse tunnels in the channel wall. J Mol Biol. 1999 May 14; 288(4):765-86. PMID: 10329178.
      View in: PubMed
    38. Stowell MH, Marks B, Wigge P, McMahon HT. Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring. Nat Cell Biol. 1999 May; 1(1):27-32. PMID: 10559860.
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    39. Tierney ML, Stowell MH. The functional significance of multimerization in ion channels. Curr Opin Struct Biol. 1998 Apr; 8(2):186-8. PMID: 9631291.
      View in: PubMed
    40. Stowell MH, McPhillips TM, Rees DC, Soltis SM, Abresch E, Feher G. Light-induced structural changes in photosynthetic reaction center: implications for mechanism of electron-proton transfer. Science. 1997 May 02; 276(5313):812-6. PMID: 9115209.
      View in: PubMed
    41. Peters JW, Stowell MH, Soltis SM, Finnegan MG, Johnson MK, Rees DC. Redox-dependent structural changes in the nitrogenase P-cluster. Biochemistry. 1997 Feb 11; 36(6):1181-7. PMID: 9063865.
      View in: PubMed
    42. Peters JW, Stowell MH, Rees DC. A leucine-rich repeat variant with a novel repetitive protein structural motif. Nat Struct Biol. 1996 Dec; 3(12):991-4. PMID: 8946850.
      View in: PubMed
    43. Stowell MH, Rees DC. Structure and stability of membrane proteins. Adv Protein Chem. 1995; 46:279-311. PMID: 7771322.
      View in: PubMed
    44. Musser SM, Stowell MH, Chan SI. Cytochrome c oxidase: chemistry of a molecular machine. Adv Enzymol Relat Areas Mol Biol. 1995; 71:79-208. PMID: 8644492.
      View in: PubMed
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