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Thomas Joseph Anchordoquy

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-6113

    Collapse Research 
    Collapse research activities and funding
    R13EB034603     (SIMBERG, DMITRI)Mar 1, 2023 - Feb 29, 2024
    NIH
    Mechanisms and Barriers in Nanomedicine-2023
    Role: Co-Principal Investigator
    R01GM129046     (ANCHORDOQUY, THOMAS)Aug 1, 2018 - Apr 30, 2022
    NIH
    Exploiting an endogenous transcytotic pathway for oral drug delivery
    Role: Principal Investigator
    R01EB016378     (ANCHORDOQUY, THOMAS)Aug 1, 2013 - Jul 31, 2018
    NIH
    Tumor-Homing Exosomes for Drug Delivery
    Role: Principal Investigator
    R01GM093287     (ANCHORDOQUY, THOMAS)Sep 15, 2011 - Aug 31, 2016
    NIH
    Exploiting Cholesterol Nanodomains to Improve Targeting
    Role: Principal Investigator
    R01EB005476     (ANCHORDOQUY, THOMAS)Apr 1, 2006 - Jan 31, 2011
    NIH
    Formulation of Synthetic Vectors as Lyophilized Products
    Role: Principal Investigator
    R01GM060587     (ANCHORDOQUY, THOMAS)Feb 1, 2000 - Jan 31, 2003
    NIH
    LYOPHILIZATION OF NONVIRAL GENE DELIVERY SYSTEMS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tilden SG, Ricco MH, Hemann EA, Anchordoquy TJ. Reducing off-target drug accumulation by exploiting a type-III interferon response. J Control Release. 2023 06; 358:729-738. PMID: 37230293.
      View in: PubMed
    2. Betker JL, Anchordoquy TJ. The Effect of Repeat Administration of Lipoplexes on Gene Delivery, Biodistribution, and Cytokine Response in Immunocompetent Tumor-Bearing Mice. J Pharm Sci. 2022 07; 111(7):1926-1936. PMID: 34929156.
      View in: PubMed
    3. Betker JL, Tilden SG, Anchordoquy TJ. Escaping to silence using an endosome-disrupting polymer. Mol Ther. 2021 10 06; 29(10):2893-2894. PMID: 34555311.
      View in: PubMed
    4. Fogueri U, Charkoftaki G, Roda G, Tuey S, Ibrahim M, Persaud I, Wempe MF, Brown JM, Thurman JM, Anchordoquy TJ, Joy MS. An evaluation of a novel nanoformulation of imatinib mesylate in a mouse model of lupus nephritis. Drug Deliv Transl Res. 2022 06; 12(6):1445-1454. PMID: 34322850.
      View in: PubMed
    5. Crommelin DJA, Anchordoquy TJ, Volkin DB, Jiskoot W, Mastrobattista E. Addressing the Cold Reality of mRNA Vaccine Stability. J Pharm Sci. 2021 03; 110(3):997-1001. PMID: 33321139.
      View in: PubMed
    6. Moghimi SM, Simberg D, Anchordoquy TJ. Tuning the Engines of Nanomedicine. Mol Ther. 2020 03 04; 28(3):693-694. PMID: 32032534.
      View in: PubMed
    7. Betker JL, Anchordoquy TJ. The Use of Lactose as an Alternative Coating for Nanoparticles. J Pharm Sci. 2020 04; 109(4):1573-1580. PMID: 32004536.
      View in: PubMed
    8. Fete MG, Betker JL, Shoemaker RK, Anchordoquy TJ. A novel method for conjugating the terminal amine of peptide ligands to cholesterol: synthesis iRGD-cholesterol. Ther Deliv. 2019 01; 10(1):11-20. PMID: 30730822.
      View in: PubMed
    9. Betker JL, Angle BM, Graner MW, Anchordoquy TJ. The Potential of Exosomes From Cow Milk for Oral Delivery. J Pharm Sci. 2019 04; 108(4):1496-1505. PMID: 30468828.
      View in: PubMed
    10. Betker JL, Jones D, Childs CR, Helm KM, Terrell K, Nagel MA, Anchordoquy TJ. Nanoparticle uptake by circulating leukocytes: A major barrier to tumor delivery. J Control Release. 2018 09 28; 286:85-93. PMID: 30030182.
      View in: PubMed
    11. Oushy S, Hellwinkel JE, Wang M, Nguyen GJ, Gunaydin D, Harland TA, Anchordoquy TJ, Graner MW. Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype. Philos Trans R Soc Lond B Biol Sci. 2018 Jan 05; 373(1737). PMID: 29158308.
      View in: PubMed
    12. Anchordoquy TJ, Simberg D. Watching the gorilla and questioning delivery dogma. J Control Release. 2017 09 28; 262:87-90. PMID: 28713040.
      View in: PubMed
    13. Betker JL, Anchordoquy TJ. Assessing the effect of a nude mouse model on nanoparticle-mediated gene delivery. Drug Deliv Transl Res. 2017 02; 7(1):162-167. PMID: 27562293.
      View in: PubMed
    14. Anchordoquy TJ, Barenholz Y, Boraschi D, Chorny M, Decuzzi P, Dobrovolskaia MA, Farhangrazi ZS, Farrell D, Gabizon A, Ghandehari H, Godin B, La-Beck NM, Ljubimova J, Moghimi SM, Pagliaro L, Park JH, Peer D, Ruoslahti E, Serkova NJ, Simberg D. Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions. ACS Nano. 2017 01 24; 11(1):12-18. PMID: 28068099.
      View in: PubMed
    15. Graner AN, Hellwinkel JE, Lencioni AM, Madsen HJ, Harland TA, Marchando P, Nguyen GJ, Wang M, Russell LM, Bemis LT, Anchordoquy TJ, Graner MW. HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line. Int J Hyperthermia. 2017 May; 33(3):303-317. PMID: 27829290.
      View in: PubMed
    16. Betker JL, Anchordoquy TJ. Nonadditive Effects of Repetitive Administration of Lipoplexes in Immunocompetent Mice. J Pharm Sci. 2017 03; 106(3):872-881. PMID: 27887890.
      View in: PubMed
    17. Redzic JS, Gomez JD, Hellwinkel JE, Anchordoquy TJ, Graner MW. Proteomic analyses of brain tumor cell lines amidst the unfolded protein response. Oncotarget. 2016 Jul 26; 7(30):47831-47847. PMID: 27323862.
      View in: PubMed
    18. Betker JL, Anchordoquy TJ. Effect of charge ratio on lipoplex-mediated gene delivery and liver toxicity. Ther Deliv. 2015; 6(11):1243-53. PMID: 26608720.
      View in: PubMed
    19. Hellwinkel JE, Redzic JS, Harland TA, Gunaydin D, Anchordoquy TJ, Graner MW. Glioma-derived extracellular vesicles selectively suppress immune responses. Neuro Oncol. 2016 Apr; 18(4):497-506. PMID: 26385614.
      View in: PubMed
    20. Kullberg M, Martinson H, Mann K, Anchordoquy TJ. Complement C3 mediated targeting of liposomes to granulocytic myeloid derived suppressor cells. Nanomedicine. 2015 Aug; 11(6):1355-63. PMID: 25839391.
      View in: PubMed
    21. Pozzi D, Caracciolo G, Capriotti AL, Cavaliere C, La Barbera G, Anchordoquy TJ, Lagan? A. Surface chemistry and serum type both determine the nanoparticle-protein corona. J Proteomics. 2015 Apr 24; 119:209-17. PMID: 25731725.
      View in: PubMed
    22. Smyth T, Kullberg M, Malik N, Smith-Jones P, Graner MW, Anchordoquy TJ. Biodistribution and delivery efficiency of unmodified tumor-derived exosomes. J Control Release. 2015 Feb 10; 199:145-55. PMID: 25523519.
      View in: PubMed
    23. Betker JL, Anchordoquy TJ. Relating toxicity to transfection: using sphingosine to maintain prolonged expression in vitro. Mol Pharm. 2015 Jan 05; 12(1):264-73. PMID: 25418523.
      View in: PubMed
    24. Payton NM, Wempe MF, Xu Y, Anchordoquy TJ. Long-term storage of lyophilized liposomal formulations. J Pharm Sci. 2014 Dec; 103(12):3869-3878. PMID: 25308534.
      View in: PubMed
    25. Smyth T, Petrova K, Payton NM, Persaud I, Redzic JS, Graner MW, Smith-Jones P, Anchordoquy TJ. Surface functionalization of exosomes using click chemistry. Bioconjug Chem. 2014 Oct 15; 25(10):1777-84. PMID: 25220352.
      View in: PubMed
    26. Verhoef JJ, Carpenter JF, Anchordoquy TJ, Schellekens H. Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics. Drug Discov Today. 2014 Dec; 19(12):1945-52. PMID: 25205349.
      View in: PubMed
    27. Smyth TJ, Redzic JS, Graner MW, Anchordoquy TJ. Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro. Biochim Biophys Acta. 2014 Nov; 1838(11):2954-65. PMID: 25102470.
      View in: PubMed
    28. Kullberg M, McCarthy R, Anchordoquy TJ. Gene delivery to Her-2+ breast cancer cells using a two-component delivery system to achieve specificity. Nanomedicine. 2014 Aug; 10(6):1253-62. PMID: 24632244.
      View in: PubMed
    29. Verhoef JJ, Anchordoquy TJ. Questioning the Use of PEGylation for Drug Delivery. Drug Deliv Transl Res. 2013 Dec; 3(6):499-503. PMID: 24932437.
      View in: PubMed
    30. Kullberg M, McCarthy R, Anchordoquy TJ. Systemic tumor-specific gene delivery. J Control Release. 2013 Dec 28; 172(3):730-6. PMID: 24035974.
      View in: PubMed
    31. Betker JL, Gomez J, Anchordoquy TJ. The effects of lipoplex formulation variables on the protein corona and comparisons with in vitro transfection efficiency. J Control Release. 2013 Nov 10; 171(3):261-8. PMID: 23920037.
      View in: PubMed
    32. Payton NM, Wempe MF, Betker JL, Randolph TW, Anchordoquy TJ. Lyophilization of a triply unsaturated phospholipid: effects of trace metal contaminants. Eur J Pharm Biopharm. 2013 Oct; 85(2):306-13. PMID: 23567484.
      View in: PubMed
    33. Betker JL, Kullberg M, Gomez J, Anchordoquy TJ. Cholesterol domains enhance transfection. Ther Deliv. 2013 Apr; 4(4):453-62. PMID: 23557286.
      View in: PubMed
    34. Epple LM, Griffiths SG, Dechkovskaia AM, Dusto NL, White J, Ouellette RJ, Anchordoquy TJ, Bemis LT, Graner MW. Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles. PLoS One. 2012; 7(7):e42064. PMID: 22848702.
      View in: PubMed
    35. Kullberg M, Mann K, Anchordoquy TJ. Targeting Her-2+ breast cancer cells with bleomycin immunoliposomes linked to LLO. Mol Pharm. 2012 Jul 02; 9(7):2000-8. PMID: 22621404.
      View in: PubMed
    36. Xu L, Betker J, Yin H, Anchordoquy TJ. Ligands located within a cholesterol domain enhance gene delivery to the target tissue. J Control Release. 2012 May 30; 160(1):57-63. PMID: 22440429.
      View in: PubMed
    37. Betker J, Smyth T, Wang W, Anchordoquy TJ. Application of a ultra performance liquid chromatography method in the determination of DNA quality and stability. J Pharm Sci. 2012 Mar; 101(3):987-97. PMID: 22113832.
      View in: PubMed
    38. Smyth TJ, Betker J, Wang W, Anchordoquy TJ. Moisture content impacts the stability of DNA adsorbed onto gold microparticles. J Pharm Sci. 2011 Nov; 100(11):4845-54. PMID: 21732371.
      View in: PubMed
    39. Lengsfeld CS, Munson L, Lentz YK, Anchordoquy TJ. DNA hydrodynamic degradation controlled by Kolomogorov length scales in pipe flow. J Pharm Sci. 2011 Aug; 100(8):3088-3095. PMID: 21523785.
      View in: PubMed
    40. Xu L, Wempe MF, Anchordoquy TJ. The effect of cholesterol domains on PEGylated liposomal gene delivery in vitro. Ther Deliv. 2011 Apr; 2(4):451-60. PMID: 22428082.
      View in: PubMed
    41. Xu L, Anchordoquy T. Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics. J Pharm Sci. 2011 Jan; 100(1):38-52. PMID: 20575003.
      View in: PubMed
    42. Xu L, Anchordoquy TJ. Effect of cholesterol nanodomains on the targeting of lipid-based gene delivery in cultured cells. Mol Pharm. 2010 Aug 02; 7(4):1311-7. PMID: 20568694.
      View in: PubMed
    43. Yu J, Anchordoquy TJ. Effects of moisture content on the storage stability of dried lipoplex formulations. J Pharm Sci. 2009 Sep; 98(9):3278-89. PMID: 19569198.
      View in: PubMed
    44. Yu J, Anchordoquy TJ. Synergistic effects of surfactants and sugars on lipoplex stability during freeze-drying and rehydration. J Pharm Sci. 2009 Sep; 98(9):3319-28. PMID: 18781626.
      View in: PubMed
    45. Molina MD, Anchordoquy TJ. Formulation strategies to minimize oxidative damage in lyophilized lipid/DNA complexes during storage. J Pharm Sci. 2008 Dec; 97(12):5089-105. PMID: 18399563.
      View in: PubMed
    46. Anchordoquy TJ, Molina Md, Kempner ES. A radiation target method for size determination of supercoiled plasmid DNA. Anal Biochem. 2009 Feb 15; 385(2):229-33. PMID: 19028447.
      View in: PubMed
    47. Zillies JC, Zwiorek K, Hoffmann F, Vollmar A, Anchordoquy TJ, Winter G, Coester C. Formulation development of freeze-dried oligonucleotide-loaded gelatin nanoparticles. Eur J Pharm Biopharm. 2008 Oct; 70(2):514-21. PMID: 18582569.
      View in: PubMed
    48. Xu L, Anchordoquy TJ. Cholesterol domains in cationic lipid/DNA complexes improve transfection. Biochim Biophys Acta. 2008 Oct; 1778(10):2177-81. PMID: 18489900.
      View in: PubMed
    49. Molina MD, Anchordoquy TJ. Degradation of lyophilized lipid/DNA complexes during storage: the role of lipid and reactive oxygen species. Biochim Biophys Acta. 2008 Oct; 1778(10):2119-26. PMID: 18445474.
      View in: PubMed
    50. Abrams DJ, Zheng L, Choo KS, Yang JJ, Wei W, Anchordoquy TJ, Zawia NH, Stevens KE. An initial animal proof-of-concept study for central administration of clozapine to schizophrenia patients. Schizophr Res. 2008 Mar; 100(1-3):86-96. PMID: 18178385.
      View in: PubMed
    51. Zhang Y, Bradshaw-Pierce EL, Delille A, Gustafson DL, Anchordoquy TJ. In vivo comparative study of lipid/DNA complexes with different in vitro serum stability: effects on biodistribution and tumor accumulation. J Pharm Sci. 2008 Jan; 97(1):237-50. PMID: 17721944.
      View in: PubMed
    52. Molina Md, Anchordoquy TJ. Metal contaminants promote degradation of lipid/DNA complexes during lyophilization. Biochim Biophys Acta. 2007 Mar; 1768(3):669-77. PMID: 17224131.
      View in: PubMed
    53. Lentz YK, Anchordoquy TJ, Lengsfeld CS. DNA acts as a nucleation site for transient cavitation in the ultrasonic nebulizer. J Pharm Sci. 2006 Mar; 95(3):607-19. PMID: 16432878.
      View in: PubMed
    54. Patel MM, Anchordoquy TJ. Ability of spermine to differentiate between DNA sequences--preferential stabilization of A-tracts. Biophys Chem. 2006 Jun 20; 122(1):5-15. PMID: 16504371.
      View in: PubMed
    55. Lentz YK, Anchordoquy TJ, Lengsfeld CS. Rationale for the selection of an aerosol delivery system for gene delivery. J Aerosol Med. 2006; 19(3):372-84. PMID: 17034312.
      View in: PubMed
    56. Anchordoquy TJ, Armstrong TK, Molina Md. Low molecular weight dextrans stabilize nonviral vectors during lyophilization at low osmolalities: concentrating suspensions by rehydration to reduced volumes. J Pharm Sci. 2005 Jun; 94(6):1226-36. PMID: 15858857.
      View in: PubMed
    57. Patel MM, Anchordoquy TJ. Contribution of hydrophobicity to thermodynamics of ligand-DNA binding and DNA collapse. Biophys J. 2005 Mar; 88(3):2089-103. PMID: 15653734.
      View in: PubMed
    58. Armstrong TK, Anchordoquy TJ. Immobilization of nonviral vectors during the freezing step of lyophilization. J Pharm Sci. 2004 Nov; 93(11):2698-709. PMID: 15389673.
      View in: PubMed
    59. Patel MM, Zeles MG, Manning MC, Randolph TW, Anchordoquy TJ. Degradation kinetics of high molecular weight poly(L-lactide) microspheres and release mechanism of lipid:DNA complexes. J Pharm Sci. 2004 Oct; 93(10):2573-84. PMID: 15349967.
      View in: PubMed
    60. Molina Md, Armstrong TK, Zhang Y, Patel MM, Lentz YK, Anchordoquy TJ. The stability of lyophilized lipid/DNA complexes during prolonged storage. J Pharm Sci. 2004 Sep; 93(9):2259-73. PMID: 15295787.
      View in: PubMed
    61. Zhang Y, Anchordoquy TJ. The role of lipid charge density in the serum stability of cationic lipid/DNA complexes. Biochim Biophys Acta. 2004 May 27; 1663(1-2):143-57. PMID: 15157617.
      View in: PubMed
    62. Zhang Y, Garzon-Rodriguez W, Manning MC, Anchordoquy TJ. The use of fluorescence resonance energy transfer to monitor dynamic changes of lipid-DNA interactions during lipoplex formation. Biochim Biophys Acta. 2003 Aug 07; 1614(2):182-92. PMID: 12896811.
      View in: PubMed
    63. Choosakoonkriang S, Wiethoff CM, Koe GS, Koe JG, Anchordoquy TJ, Middaugh CR. An infrared spectroscopic study of the effect of hydration on cationic lipid/DNA complexes. J Pharm Sci. 2003 Jan; 92(1):115-30. PMID: 12486688.
      View in: PubMed
    64. Pikal-Cleland KA, Cleland JL, Anchordoquy TJ, Carpenter JF. Effect of glycine on pH changes and protein stability during freeze-thawing in phosphate buffer systems. J Pharm Sci. 2002 Sep; 91(9):1969-79. PMID: 12210044.
      View in: PubMed
    65. Lengsfeld CS, Anchordoquy TJ. Shear-induced degradation of plasmid DNA. J Pharm Sci. 2002 Jul; 91(7):1581-9. PMID: 12115820.
      View in: PubMed
    66. Molina MC, Allison SD, Anchordoquy TJ. Maintenance of nonviral vector particle size during the freezing step of the lyophilization process is insufficient for preservation of activity: insight from other structural indicators. J Pharm Sci. 2001 Oct; 90(10):1445-55. PMID: 11745704.
      View in: PubMed
    67. Anchordoquy TJ, Izutsu KI, Randolph TW, Carpenter JF. Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze-drying. Arch Biochem Biophys. 2001 Jun 01; 390(1):35-41. PMID: 11368512.
      View in: PubMed
    68. Anchordoquy TJ, Allison SD, Molina MC, Girouard LG, Carson TK. Physical stabilization of DNA-based therapeutics. Drug Discov Today. 2001 May 01; 6(9):463-470. PMID: 11344031.
      View in: PubMed
    69. Lee H, Williams SK, Allison SD, Anchordoquy TJ. Analysis of self-assembled cationic lipid-DNA gene carrier complexes using flow field-flow fractionation and light scattering. Anal Chem. 2001 Feb 15; 73(4):837-43. PMID: 11248901.
      View in: PubMed
    70. Allison SD, Anchordoquy TJ. Lyophilization of nonviral gene delivery systems. Methods Mol Med. 2001; 65:225-52. PMID: 21318758.
      View in: PubMed
    71. Choosakoonkriang S, Wiethoff CM, Anchordoquy TJ, Koe GS, Smith JG, Middaugh CR. Infrared spectroscopic characterization of the interaction of cationic lipids with plasmid DNA. J Biol Chem. 2001 Mar 16; 276(11):8037-43. PMID: 11118456.
      View in: PubMed
    72. Allison SD, Molina MC, Anchordoquy TJ. Stabilization of lipid/DNA complexes during the freezing step of the lyophilization process: the particle isolation hypothesis. Biochim Biophys Acta. 2000 Sep 29; 1468(1-2):127-38. PMID: 11018658.
      View in: PubMed
    73. Allison SD, Anchordoquy TJ. Mechanisms of protection of cationic lipid-DNA complexes during lyophilization. J Pharm Sci. 2000 May; 89(5):682-91. PMID: 10756334.
      View in: PubMed
    74. Anchordoquy TJ, Koe GS. Physical stability of nonviral plasmid-based therapeutics. J Pharm Sci. 2000 Mar; 89(3):289-96. PMID: 10707010.
      View in: PubMed
    75. Anchordoquy T. The center for pharmaceutical biotechnology--1999 macromolecular drug delivery conference. IDrugs. 1999 Oct; 2(10):1005-8. PMID: 16118709.
      View in: PubMed
    76. Anchordoquy TJ, Girouard LG, Carpenter JF, Kroll DJ. Stability of lipid/DNA complexes during agitation and freeze-thawing. J Pharm Sci. 1998 Sep; 87(9):1046-51. PMID: 9724553.
      View in: PubMed
    77. Anchordoquy TJ, Carpenter JF, Kroll DJ. Maintenance of transfection rates and physical characterization of lipid/DNA complexes after freeze-drying and rehydration. Arch Biochem Biophys. 1997 Dec 01; 348(1):199-206. PMID: 9390192.
      View in: PubMed
    78. Anchordoquy TJ, Carpenter JF. Polymers protect lactate dehydrogenase during freeze-drying by inhibiting dissociation in the frozen state. Arch Biochem Biophys. 1996 Aug 15; 332(2):231-8. PMID: 8806730.
      View in: PubMed
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