 Maria Natalia Vergara
| Title | Assistant Professor |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-OP General Operations |
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| Title | Director-Faculty |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-OP General Operations |
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 Biography | Johns Hopkins School of Medicine, Baltimore, MD | Post-doctoral Fellowship | 06/2017 | Eye development and regenerative therapy | | Miami University, Oxford, OH | Ph.D. | 05/2008 | Retinal regenerative biology | | Universidad Nacional del Litoral, Parana, Argentina | Biochemist (B.S.) | 08/1998 | Biochemistry |
Overview My research using a combination of traditional animal models and state-of-the-art human stem cell-derived retinal organoids is focused on two key areas:
I). Understanding the mechanisms of early eye formation and the dynamics of retinal ganglion cell development in a human context.
II). Exploring the retinal manifestations of neurodegenerative diseases, particularly those associated with aging.
In this context, development and aging are viewed as the two sides of the life cycle of the retinal tissue. This program thus seeks to further our understanding of these fundamental biological processes, as well as to develop biological markers and therapeutic approaches to neural retinal degenerative disease.
Bibliographic
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Vielle A, Park YK, Secora C, Vergara MN. Organoids for the Study of Retinal Development and Developmental Abnormalities. Front Cell Neurosci. 2021; 15:667880. PMID: 34025363.
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Aasen DM, Vergara MN. New Drug Discovery Paradigms for Retinal Diseases: A Focus on Retinal Organoids. J Ocul Pharmacol Ther. 2020 Jan/Feb; 36(1):18-24. PMID: 31059378.
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Vergara MN, Tsissios G, Del Rio-Tsonis K. Lens regeneration: a historical perspective. Int J Dev Biol. 2018; 62(6-7-8):351-361. PMID: 29877565.
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Canto-Soler V, Flores-Bellver M, Vergara MN. Stem Cell Sources and Their Potential for the Treatment of Retinal Degenerations. Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(5):ORSFd1-9. PMID: 27116661.
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Vergara MN, Gutierrez C, Canto-Soler MV. Efficient Gene Transfer in Chick Retinas for Primary Cell Culture Studies: An Ex-ovo Electroporation Approach. J Vis Exp. 2015 Nov 02; (105):e52002. PMID: 26556302.
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Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Cao LH, Peters A, Park TS, Zambidis ET, Meyer JS, Gamm DM, Yau KW, Canto-Soler MV. Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat Commun. 2014 Jun 10; 5:4047. PMID: 24915161.
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Vergara MN, Gutierrez C, O'Brien DR, Canto-Soler MV. Ex vivo electroporation of retinal cells: a novel, high efficiency method for functional studies in primary retinal cultures. Exp Eye Res. 2013 Apr; 109:40-50. PMID: 23370269.
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Vergara MN, Canto-Soler MV. Rediscovering the chick embryo as a model to study retinal development. Neural Dev. 2012 Jun 27; 7:22. PMID: 22738172.
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Yoshikawa T, Mizuno A, Yasumuro H, Inami W, Vergara MN, Del Rio-Tsonis K, Chiba C. MEK-ERK and heparin-susceptible signaling pathways are involved in cell-cycle entry of the wound edge retinal pigment epithelium cells in the adult newt. Pigment Cell Melanoma Res. 2012 Jan; 25(1):66-82. PMID: 22026648.
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Vergara MN, de la Rosa EJ, Canto-Soler MV. Focus on molecules: proinsulin in the eye: precursor or pioneer? Exp Eye Res. 2012 Aug; 101:109-10. PMID: 21144848.
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Vergara MN, Del Rio-Tsonis K. Retinal regeneration in the Xenopus laevis tadpole: a new model system. Mol Vis. 2009 May 18; 15:1000-13. PMID: 19461929.
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Vergara MN, Smiley LK, Del Rio-Tsonis K, Tsonis PA. The alpha1 isoform of the Na+/K+ ATPase is up-regulated in dedifferentiated progenitor cells that mediate lens and retina regeneration in adult newts. Exp Eye Res. 2009 Feb; 88(2):314-22. PMID: 18755185.
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Izaguirre MF, Vergara MN, Casco VH. CAS role in the brain apoptosis of Bufo arenarum induced by cypermethrin. Biocell. 2006 Aug; 30(2):309-20. PMID: 16972556.
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Casco VH, Izaguirre MF, Mar?n L, Vergara MN, Lajmanovich RC, Peltzer P, Soler AP. Apoptotic cell death in the central nervous system of Bufo arenarum tadpoles induced by cypermethrin. Cell Biol Toxicol. 2006 May; 22(3):199-211. PMID: 16570123.
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Grogg MW, Call MK, Okamoto M, Vergara MN, Del Rio-Tsonis K, Tsonis PA. BMP inhibition-driven regulation of six-3 underlies induction of newt lens regeneration. Nature. 2005 Dec 08; 438(7069):858-62. PMID: 16341014.
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Vergara MN, Arsenijevic Y, Del Rio-Tsonis K. CNS regeneration: a morphogen's tale. J Neurobiol. 2005 Sep 15; 64(4):491-507. PMID: 16041757.
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Tsonis PA, Vergara MN, Spence JR, Madhavan M, Kramer EL, Call MK, Santiago WG, Vallance JE, Robbins DJ, Del Rio-Tsonis K. A novel role of the hedgehog pathway in lens regeneration. Dev Biol. 2004 Mar 15; 267(2):450-61. PMID: 15013805.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2004 | 1 | | 2005 | 2 | | 2006 | 2 | | 2008 | 1 | | 2009 | 1 | | 2010 | 1 | | 2011 | 1 | | 2012 | 1 | | 2013 | 1 | | 2014 | 1 | | 2015 | 1 | | 2016 | 1 | | 2018 | 1 | | 2019 | 1 | | 2021 | 1 |
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