 Complementarity Determining Regions
"Complementarity Determining Regions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
| Descriptor ID |
D022801
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| MeSH Number(s) |
D12.644.541.500.650.500.180 D12.776.124.486.485.680.650.500.180 D12.776.124.486.485.797.180 D12.776.124.790.651.680.650.500.180 D12.776.124.790.651.797.180 D12.776.377.715.548.680.650.500.180 D12.776.377.715.548.797.180 D12.776.543.750.705.816.824.300 G02.111.570.060.425.160
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| Concept/Terms |
Complementarity Determining Regions- Complementarity Determining Regions
- Region, Complementarity Determining
- Regions, Complementarity Determining
- Hypervariable Regions, Immunoglobulin
- Hypervariable Region, Immunoglobulin
- Immunoglobulin Hypervariable Region
- Immunoglobulin Hypervariable Regions
- Region, Immunoglobulin Hypervariable
- Regions, Immunoglobulin Hypervariable
- Complementarity Determining Region
- Complementarity-Determining Region
- Complementarity-Determining Regions
- Regions, Complementarity-Determining
Complementarity Determining Region 3- Complementarity Determining Region 3
- Complementarity-Determining Region 3
- Complementarity-Determining Region 3s
- Third Complementarity-Determining Region
- Complementarity-Determining Region, Third
- Complementarity-Determining Regions, Third
- Third Complementarity Determining Region
- Third Complementarity-Determining Regions
- Complementarity Determining Region III
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Below are MeSH descriptors whose meaning is more general than "Complementarity Determining Regions".
Below are MeSH descriptors whose meaning is more specific than "Complementarity Determining Regions".
This graph shows the total number of publications written about "Complementarity Determining Regions" by people in this website by year, and whether "Complementarity Determining Regions" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 1 | 2 | | 2006 | 1 | 0 | 1 | | 2007 | 0 | 2 | 2 | | 2008 | 1 | 1 | 2 | | 2009 | 0 | 3 | 3 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 1 | 2 | | 2012 | 2 | 1 | 3 | | 2014 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 | | 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complementarity Determining Regions" by people in Profiles.
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Petersen BM, Kirby MB, Chrispens KM, Irvin OM, Strawn IK, Haas CM, Walker AM, Baumer ZT, Ulmer SA, Ayala E, Rhodes ER, Guthmiller JJ, Steiner PJ, Whitehead TA. An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries. Nat Commun. 2024 May 10; 15(1):3974.
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Lagattuta KA, Kang JB, Nathan A, Pauken KE, Jonsson AH, Rao DA, Sharpe AH, Ishigaki K, Raychaudhuri S. Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate. Nat Immunol. 2022 03; 23(3):446-457.
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Boughter CT, Borowska MT, Guthmiller JJ, Bendelac A, Wilson PC, Roux B, Adams EJ. Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops. Elife. 2020 11 10; 9.
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Na H, Laver JD, Jeon J, Singh F, Ancevicius K, Fan Y, Cao WX, Nie K, Yang Z, Luo H, Wang M, Rissland O, Westwood JT, Kim PM, Smibert CA, Lipshitz HD, Sidhu SS. A high-throughput pipeline for the production of synthetic antibodies for analysis of ribonucleoprotein complexes. RNA. 2016 Apr; 22(4):636-55.
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Bowers E, Scamurra RW, Asrani A, Beniguel L, MaWhinney S, Keays KM, Thurn JR, Janoff EN. Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection. PLoS One. 2014; 9(1):e81913.
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Giannoni F, Hardee CL, Wherley J, Gschweng E, Senadheera S, Kaufman ML, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte ON, Economou JS, Ribas A, Kohn DB. Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells. Mol Ther. 2013 May; 21(5):1044-54.
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Menezes CA, Sullivan AK, Falta MT, Mack DG, Freed BM, Rocha MO, Gollob KJ, Fontenot AP, Dutra WO. Highly conserved CDR3 region in circulating CD4(+)V?5(+) T cells may be associated with cytotoxic activity in Chagas disease. Clin Exp Immunol. 2012 Aug; 169(2):109-18.
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Jordan KR, Buhrman JD, Sprague J, Moore BL, Gao D, Kappler JW, Slansky JE. TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines. Cancer Immunol Immunother. 2012 Oct; 61(10):1627-38.
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Nakayama M, Castoe T, Sosinowski T, He X, Johnson K, Haskins K, Vignali DA, Gapin L, Pollock D, Eisenbarth GS. Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice. Diabetes. 2012 Apr; 61(4):857-65.
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Zhang A, Singh SK, Shirts MR, Kumar S, Fernandez EJ. Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange. Pharm Res. 2012 Jan; 29(1):236-50.
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