Brooks M Hybertson
Title | Affiliate - DHHA |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-MED |
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Phone | 303/315-5510 |
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Research R43AG053128 (HYBERTSON, BROOKS MICHAEL)Apr 1, 2017 - Sep 30, 2018 NIH Supporting Healthy Aging with a Phytochemical Combination that Acts at Multiple Control Points in the Nrf2 Activation Pathway Role: Principal Investigator |
| R43DE026086 (HYBERTSON, BROOKS MICHAEL)Mar 15, 2017 - Dec 14, 2018 NIH A Topical Nrf2 Activator for Oral Mucositis Role: Principal Investigator |
| R43AI076196 (HYBERTSON, BROOKS MICHAEL)Aug 1, 2007 - Jan 31, 2009 NIH Low Cost Production of the Malaria Drug Artemether Role: Principal Investigator |
| R03AI061722 (HYBERTSON, BROOKS MICHAEL)Sep 30, 2004 - Aug 31, 2005 NIH Respirable ciprofloxacin aerosol for inhaled anthrax Role: Principal Investigator |
Bibliographic
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McCord JM, Gao B, Hybertson BM. The Complex Genetic and Epigenetic Regulation of the Nrf2 Pathways: A Review. Antioxidants (Basel). 2023 Feb 03; 12(2). PMID: 36829925.
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Musci RV, Andrie KM, Walsh MA, Valenti ZJ, Linden MA, Afzali MF, Bork S, Campbell M, Johnson T, Kail TE, Martinez R, Nguyen T, Sanford J, Wist S, Murrell MD, McCord JM, Hybertson BM, Zhang Q, Javors MA, Santangelo KS, Hamilton KL. Phytochemical compound PB125 attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a model of musculoskeletal decline. J Physiol. 2023 06; 601(11):2189-2216. PMID: 35924591.
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Hybertson BM, Gao B, McCord JM. Effects of the Phytochemical Combination PB123 on Nrf2 Activation, Gene Expression, and the Cholesterol Pathway in HepG2 Cells. OBM Integr Compliment Med. 2022; 7(1). PMID: 35252766.
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McCord JM, Hybertson BM, Cota-Gomez A, Gao B. Nrf2 activator PB125? as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19. Free Radic Biol Med. 2021 11 01; 175:56-64. PMID: 34058321.
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Agostini M, Hininger-Favier I, Marcourt L, Boucherle B, Gao B, Hybertson BM, Bose SK, McCord JM, Millery A, Rome M, Ferreira Queiroz E, Wolfender JL, Gallet C, Boumendjel A. Phytochemical and Biological Investigation of Helianthemum nummularium, a High-Altitude Growing Alpine Plant Overrepresented in Ungulates Diets. Planta Med. 2020 Nov; 86(16):1185-1190. PMID: 32645735.
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McCord JM, Hybertson BM, Cota-Gomez A, Geraci KP, Gao B. Nrf2 Activator PB125? as a Potential Therapeutic Agent against COVID-19. Antioxidants (Basel). 2020 Jun 12; 9(6). PMID: 32545518.
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McCord JM, Hybertson BM, Cota-Gomez A, Gao B. Nrf2 Activator PB125? as a Potential Therapeutic Agent Against COVID-19. bioRxiv. 2020 Jun 10. PMID: 32511372.
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Simenauer A, Assefa B, Rios-Ochoa J, Geraci K, Hybertson B, Gao B, McCord J, Elajaili H, Nozik-Grayck E, Cota-Gomez A. Repression of Nrf2/ARE regulated antioxidant genes and dysregulation of the cellular redox environment by the HIV Transactivator of Transcription. Free Radic Biol Med. 2019 09; 141:244-252. PMID: 31238128.
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Kukoyi AT, Fan X, Staitieh BS, Hybertson BM, Gao B, McCord JM, Guidot DM. MiR-144 mediates Nrf2 inhibition and alveolar epithelial dysfunction in HIV-1 transgenic rats. Am J Physiol Cell Physiol. 2019 08 01; 317(2):C390-C397. PMID: 31091144.
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Hybertson BM, Gao B, Bose S, McCord JM. Phytochemical Combination PB125 Activates the Nrf2 Pathway and Induces Cellular Protection against Oxidative Injury. Antioxidants (Basel). 2019 May 03; 8(5). PMID: 31058853.
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Joslin JM, McCall JR, Bzdek JP, Johnson DC, Hybertson BM. Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications. Plasma Med. 2016; 6(2):135-177. PMID: 28428835.
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Hybertson BM, Gao B. Role of the Nrf2 signaling system in health and disease. Clin Genet. 2014 Nov; 86(5):447-52. PMID: 25099075.
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Gao B, Doan A, Hybertson BM. The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders. Clin Pharmacol. 2014; 6:19-34. PMID: 24520207.
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Hybertson BM, Gao B, Bose SK, McCord JM. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011 Aug; 32(4-6):234-46. PMID: 22020111.
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Hybertson BM. Solubility of a-Tocopheryl Succinate in Supercritical Carbon Dioxide Using Offline HPLC-MS/MS Analysis. J Chem Eng Data. 2007 May; 52(3):1123-1127. PMID: 20953319.
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Hybertson BM. Solubility of the sesquiterpene alcohol patchoulol in supercritical carbon dioxide. J Chem Eng Data. 2007 Jan 01; 52(1):235-238. PMID: 19424449.
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Ng KY, Zhou H, Zhang YL, Hybertson B, Randolph T, Christians U. Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Mar 01; 847(2):188-98. PMID: 17070115.
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Zhou H, Zhang Y, Biggs DL, Manning MC, Randolph TW, Christians U, Hybertson BM, Ng KY. Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages. J Control Release. 2005 Oct 03; 107(2):288-99. PMID: 16009444.
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Dunn JS, Nayar R, Campos J, Hybertson BM, Zhou Y, Manning MC, Repine JE, Stringer KA. Feasibility of tissue plasminogen activator formulated for pulmonary delivery. Pharm Res. 2005 Oct; 22(10):1700-7. PMID: 16180128.
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Hybertson BM, Chung JH, Fini MA, Lee YM, Allard JD, Hansen BN, Cho OJ, Shibao GN, Repine JE. Aerosol-administered alpha-tocopherol attenuates lung inflammation in rats given lipopolysaccharide intratracheally. Exp Lung Res. 2005 Apr; 31(3):283-94. PMID: 15962709.
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Yoon-yub P, Hybertson B, Wright R, Fini M, Elkins N, Repine J. Serum ferritin elevation and acute lung injury in rats subjected to hemorrhage: reduction by mepacrine treatment. Exp Lung Res. 2004 Oct-Nov; 30(7):571-84. PMID: 15371093.
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Biggs DL, Lengsfeld CS, Hybertson BM, Ng KY, Manning MC, Randolph TW. In vitro and in vivo evaluation of the effects of PLA microparticle crystallinity on cellular response. J Control Release. 2003 Sep 19; 92(1-2):147-61. PMID: 14499193.
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Hybertson BM, Jepson EK, Allard JD, Cho OJ, Lee YM, Huddleston JR, Weinman JP, Oliva AM, Repine JE. Transforming growth factor beta contributes to lung leak in rats given interleukin-1 intratracheally. Exp Lung Res. 2003 Sep; 29(6):361-73. PMID: 12888449.
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Park YY, Hybertson BM, Wright RM, Repine JE. Serum ferritin increases in hemorrhaged rats that develop acute lung injury: effect of an iron-deficient diet. Inflammation. 2003 Aug; 27(4):257-63. PMID: 14527178.
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Lee YM, Hybertson BM, Cho HG, Repine JE. Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil-lung endothelial cell interfaces. J Lab Clin Med. 2002 Nov; 140(5):312-9. PMID: 12434132.
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Hybertson BM, Connelly KG, Buser RT, Repine JE. Ferritin and desferrioxamine attenuate xanthine oxidase-dependent leak in isolated perfused rat lungs. Inflammation. 2002 Aug; 26(4):153-9. PMID: 12184628.
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Zhou H, Lengsfeld C, Claffey DJ, Ruth JA, Hybertson B, Randolph TW, Ng KY, Manning MC. Hydrophobic ion pairing of isoniazid using a prodrug approach. J Pharm Sci. 2002 Jun; 91(6):1502-11. PMID: 12115849.
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Hybertson BM, Lee YM, Cho HG, Cho OJ, Repine JE. Alveolar type II cell abnormalities and peroxide formation in lungs of rats given IL-1 intratracheally. Inflammation. 2000 Aug; 24(4):289-303. PMID: 10850852.
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Lee YM, Hybertson BM, Cho HG, Terada LS, Cho O, Repine AJ, Repine JE. Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. Am J Physiol Lung Cell Mol Physiol. 2000 Jul; 279(1):L75-80. PMID: 10893205.
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Guidot DM, Kitlowski AD, Hybertson BM, Repine JE. Mitochondrial antioxidant function is a potential mechanism for organ differences in interleukin-1-mediated tolerance to oxidative injury. Am J Med Sci. 1999 Nov; 318(5):308-15. PMID: 10555093.
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Stringer KA, Hybertson BM, Cho OJ, Cohen Z, Repine JE. Tissue plasminogen activator (tPA) inhibits interleukin-1 induced acute lung leak. Free Radic Biol Med. 1998 Jul 15; 25(2):184-8. PMID: 9667494.
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Hybertson BM, Kitlowski RP, Jepson EK, Repine JE. Supercritical fluid-aerosolized vitamin E pretreatment decreases leak in isolated oxidant-perfused rat lungs. J Appl Physiol (1985). 1998 Jan; 84(1):263-8. PMID: 9451645.
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Hybertson BM, Lee YM, Repine JE. Phagocytes and acute lung injury: dual roles for interleukin-1. Ann N Y Acad Sci. 1997 Dec 15; 832:266-73. PMID: 9704053.
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Guidot DM, Bursten SL, Rice GC, Chaney RB, Singer JW, Repine AJ, Hybertson BM, Repine JE. Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs. Am J Physiol. 1997 11; 273(5):L957-66. PMID: 9374722.
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Hybertson BM, Jepson EK, Cho OJ, Clarke JH, Lee YM, Repine JE. TNF mediates lung leak, but not neutrophil accumulation, in lungs of rats given IL-1 intratracheally. Am J Respir Crit Care Med. 1997 Jun; 155(6):1972-6. PMID: 9196104.
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Lee YM, Hybertson BM, Terada LS, Repine AJ, Cho HG, Repine JE. Mepacrine decreases lung leak in rats given interleukin-1 intratracheally. Am J Respir Crit Care Med. 1997 May; 155(5):1624-8. PMID: 9154867.
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Terada LS, Hybertson BM, Connelly KG, Weill D, Piermattei D, Repine JE. XO increases neutrophil adherence to endothelial cells by a dual ICAM-1 and P-selectin-mediated mechanism. J Appl Physiol (1985). 1997 Mar; 82(3):866-73. PMID: 9074976.
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Terada LS, Repine JE, Piermattei D, Hybertson BM. Endogenous nitric oxide decreases xanthine oxidase-mediated neutrophil adherence: role of P-selectin. J Appl Physiol (1985). 1997 Mar; 82(3):913-7. PMID: 9074982.
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Hybertson BM, Bursten SL, Leff JA, Lee YM, Jepson EK, Dewitt CR, Zagorski J, Cho HG, Repine JE. Lisofylline prevents leak, but not neutrophil accumulation, in lungs of rats given IL-1 intratracheally. J Appl Physiol (1985). 1997 Jan; 82(1):226-32. PMID: 9029220.
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Hybertson BM, Jepson EK, Clarke JH, Spelts RJ, Repine JB. Interleukin-1 stimulates rapid release of cytokine-induced neutrophil chemoattractant (CINC) in rat lungs. Inflammation. 1996 Oct; 20(5):471-83. PMID: 8894712.
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Koh Y, Hybertson BM, Jepson EK, Repine JE. Tumor necrosis factor induced acute lung leak in rats: less than with interleukin-1. Inflammation. 1996 Oct; 20(5):461-9. PMID: 8894711.
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Guidot DM, Hybertson BM, Kitlowski RP, Repine JE. Inhaled NO prevents IL-1-induced neutrophil accumulation and associated acute edema in isolated rat lungs. Am J Physiol. 1996 Aug; 271(2 Pt 1):L225-9. PMID: 8770060.
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Hybertson BM, Lampey AS, Clarke JH, Koh Y, Repine JE. N-acetylcysteine pretreatment attenuates paraquat-induced lung leak in rats. Redox Rep. 1995 Nov; 1(5):337-42. PMID: 27405831.
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Koh Y, Hybertson BM, Jepson EK, Cho OJ, Repine JE. Cytokine-induced neutrophil chemoattractant is necessary for interleukin-1-induced lung leak in rats. J Appl Physiol (1985). 1995 Aug; 79(2):472-8. PMID: 7592205.
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Guidot DM, Repine MJ, Hybertson BM, Repine JE. Inhaled nitric oxide prevents neutrophil-mediated, oxygen radical-dependent leak in isolated rat lungs. Am J Physiol. 1995 Jul; 269(1 Pt 1):L2-5. PMID: 7631809.
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Hybertson BM, Leff JA, Beehler CJ, Barry PC, Repine JE. Effect of vitamin E deficiency and supercritical fluid aerosolized vitamin E supplementation on interleukin-1-induced oxidative lung injury in rats. Free Radic Biol Med. 1995 Mar; 18(3):537-42. PMID: 9101244.
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Leff JA, Wilke CP, Hybertson BM, Shanley PF, Beehler CJ, Repine JE. Postinsult treatment with N-acetyl-L-cysteine decreases IL-1-induced neutrophil influx and lung leak in rats. Am J Physiol. 1993 Nov; 265(5 Pt 1):L501-6. PMID: 8238538.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1995 | 4 | 1996 | 3 | 1997 | 7 | 1998 | 2 | 1999 | 1 | 2000 | 2 | 2002 | 3 | 2003 | 3 | 2004 | 1 | 2005 | 3 | 2006 | 1 | 2007 | 2 | 2011 | 1 | 2014 | 2 | 2016 | 1 | 2019 | 3 | 2020 | 3 | 2021 | 1 | 2022 | 2 | 2023 | 1 |
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