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Brooks M Hybertson

TitleAffiliate - DHHA
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/315-5510

    Collapse Research 
    Collapse research activities and funding
    R43AG053128     (HYBERTSON, BROOKS MICHAEL)Apr 1, 2017 - Sep 30, 2018
    NIH
    Supporting Healthy Aging with a Phytochemical Combination that Acts at Multiple Control Points in the Nrf2 Activation Pathway
    Role: Principal Investigator
    R43DE026086     (HYBERTSON, BROOKS MICHAEL)Mar 15, 2017 - Dec 14, 2018
    NIH
    A Topical Nrf2 Activator for Oral Mucositis
    Role: Principal Investigator
    R43AI076196     (HYBERTSON, BROOKS MICHAEL)Aug 1, 2007 - Jan 31, 2009
    NIH
    Low Cost Production of the Malaria Drug Artemether
    Role: Principal Investigator
    R03AI061722     (HYBERTSON, BROOKS MICHAEL)Sep 30, 2004 - Aug 31, 2005
    NIH
    Respirable ciprofloxacin aerosol for inhaled anthrax
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. McCord JM, Gao B, Hybertson BM. The Complex Genetic and Epigenetic Regulation of the Nrf2 Pathways: A Review. Antioxidants (Basel). 2023 Feb 03; 12(2). PMID: 36829925.
      View in: PubMed
    2. Musci RV, Andrie KM, Walsh MA, Valenti ZJ, Linden MA, Afzali MF, Bork S, Campbell M, Johnson T, Kail TE, Martinez R, Nguyen T, Sanford J, Wist S, Murrell MD, McCord JM, Hybertson BM, Zhang Q, Javors MA, Santangelo KS, Hamilton KL. Phytochemical compound PB125 attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a model of musculoskeletal decline. J Physiol. 2023 06; 601(11):2189-2216. PMID: 35924591.
      View in: PubMed
    3. Hybertson BM, Gao B, McCord JM. Effects of the Phytochemical Combination PB123 on Nrf2 Activation, Gene Expression, and the Cholesterol Pathway in HepG2 Cells. OBM Integr Compliment Med. 2022; 7(1). PMID: 35252766.
      View in: PubMed
    4. McCord JM, Hybertson BM, Cota-Gomez A, Gao B. Nrf2 activator PB125? as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19. Free Radic Biol Med. 2021 11 01; 175:56-64. PMID: 34058321.
      View in: PubMed
    5. Agostini M, Hininger-Favier I, Marcourt L, Boucherle B, Gao B, Hybertson BM, Bose SK, McCord JM, Millery A, Rome M, Ferreira Queiroz E, Wolfender JL, Gallet C, Boumendjel A. Phytochemical and Biological Investigation of Helianthemum nummularium, a High-Altitude Growing Alpine Plant Overrepresented in Ungulates Diets. Planta Med. 2020 Nov; 86(16):1185-1190. PMID: 32645735.
      View in: PubMed
    6. McCord JM, Hybertson BM, Cota-Gomez A, Geraci KP, Gao B. Nrf2 Activator PB125? as a Potential Therapeutic Agent against COVID-19. Antioxidants (Basel). 2020 Jun 12; 9(6). PMID: 32545518.
      View in: PubMed
    7. McCord JM, Hybertson BM, Cota-Gomez A, Gao B. Nrf2 Activator PB125? as a Potential Therapeutic Agent Against COVID-19. bioRxiv. 2020 Jun 10. PMID: 32511372.
      View in: PubMed
    8. Simenauer A, Assefa B, Rios-Ochoa J, Geraci K, Hybertson B, Gao B, McCord J, Elajaili H, Nozik-Grayck E, Cota-Gomez A. Repression of Nrf2/ARE regulated antioxidant genes and dysregulation of the cellular redox environment by the HIV Transactivator of Transcription. Free Radic Biol Med. 2019 09; 141:244-252. PMID: 31238128.
      View in: PubMed
    9. Kukoyi AT, Fan X, Staitieh BS, Hybertson BM, Gao B, McCord JM, Guidot DM. MiR-144 mediates Nrf2 inhibition and alveolar epithelial dysfunction in HIV-1 transgenic rats. Am J Physiol Cell Physiol. 2019 08 01; 317(2):C390-C397. PMID: 31091144.
      View in: PubMed
    10. Hybertson BM, Gao B, Bose S, McCord JM. Phytochemical Combination PB125 Activates the Nrf2 Pathway and Induces Cellular Protection against Oxidative Injury. Antioxidants (Basel). 2019 May 03; 8(5). PMID: 31058853.
      View in: PubMed
    11. Joslin JM, McCall JR, Bzdek JP, Johnson DC, Hybertson BM. Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications. Plasma Med. 2016; 6(2):135-177. PMID: 28428835.
      View in: PubMed
    12. Gao B, Doan A, Hybertson BM. The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders. Clin Pharmacol. 2014; 6:19-34. PMID: 24520207.
      View in: PubMed
    13. Hybertson BM, Gao B, Bose SK, McCord JM. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011 Aug; 32(4-6):234-46. PMID: 22020111.
      View in: PubMed
    14. Hybertson BM. Solubility of a-Tocopheryl Succinate in Supercritical Carbon Dioxide Using Offline HPLC-MS/MS Analysis. J Chem Eng Data. 2007 May; 52(3):1123-1127. PMID: 20953319.
      View in: PubMed
    15. Hybertson BM. Solubility of the sesquiterpene alcohol patchoulol in supercritical carbon dioxide. J Chem Eng Data. 2007 Jan 01; 52(1):235-238. PMID: 19424449.
      View in: PubMed
    16. Ng KY, Zhou H, Zhang YL, Hybertson B, Randolph T, Christians U. Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Mar 01; 847(2):188-98. PMID: 17070115.
      View in: PubMed
    17. Zhou H, Zhang Y, Biggs DL, Manning MC, Randolph TW, Christians U, Hybertson BM, Ng KY. Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages. J Control Release. 2005 Oct 03; 107(2):288-99. PMID: 16009444.
      View in: PubMed
    18. Dunn JS, Nayar R, Campos J, Hybertson BM, Zhou Y, Manning MC, Repine JE, Stringer KA. Feasibility of tissue plasminogen activator formulated for pulmonary delivery. Pharm Res. 2005 Oct; 22(10):1700-7. PMID: 16180128.
      View in: PubMed
    19. Hybertson BM, Chung JH, Fini MA, Lee YM, Allard JD, Hansen BN, Cho OJ, Shibao GN, Repine JE. Aerosol-administered alpha-tocopherol attenuates lung inflammation in rats given lipopolysaccharide intratracheally. Exp Lung Res. 2005 Apr; 31(3):283-94. PMID: 15962709.
      View in: PubMed
    20. Yoon-yub P, Hybertson B, Wright R, Fini M, Elkins N, Repine J. Serum ferritin elevation and acute lung injury in rats subjected to hemorrhage: reduction by mepacrine treatment. Exp Lung Res. 2004 Oct-Nov; 30(7):571-84. PMID: 15371093.
      View in: PubMed
    21. Biggs DL, Lengsfeld CS, Hybertson BM, Ng KY, Manning MC, Randolph TW. In vitro and in vivo evaluation of the effects of PLA microparticle crystallinity on cellular response. J Control Release. 2003 Sep 19; 92(1-2):147-61. PMID: 14499193.
      View in: PubMed
    22. Hybertson BM, Jepson EK, Allard JD, Cho OJ, Lee YM, Huddleston JR, Weinman JP, Oliva AM, Repine JE. Transforming growth factor beta contributes to lung leak in rats given interleukin-1 intratracheally. Exp Lung Res. 2003 Sep; 29(6):361-73. PMID: 12888449.
      View in: PubMed
    23. Park YY, Hybertson BM, Wright RM, Repine JE. Serum ferritin increases in hemorrhaged rats that develop acute lung injury: effect of an iron-deficient diet. Inflammation. 2003 Aug; 27(4):257-63. PMID: 14527178.
      View in: PubMed
    24. Zhou H, Lengsfeld C, Claffey DJ, Ruth JA, Hybertson B, Randolph TW, Ng KY, Manning MC. Hydrophobic ion pairing of isoniazid using a prodrug approach. J Pharm Sci. 2002 Jun; 91(6):1502-11. PMID: 12115849.
      View in: PubMed
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