 Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subgroup of cyclic nucleotide-regulated ION CHANNELS of the superfamily of pore-loop cation channels that are opened by hyperpolarization rather than depolarization. The ion conducting pore passes SODIUM, CALCIUM, and POTASSIUM cations with a preference for potassium.
| Descriptor ID |
D064428
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| MeSH Number(s) |
D12.776.157.530.400.368 D12.776.543.550.450.476 D12.776.543.585.400.476
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| Concept/Terms |
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels- Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
- Hyperpolarization Activated Cyclic Nucleotide Gated Channels
- Ih Cation Channels
- Cation Channels, Ih
- Channels, Ih Cation
- Hyperpolarization Cyclic-Nucleotide Gated Ion Channels
- Hyperpolarization Cyclic Nucleotide Gated Ion Channels
- I(h) Channels
- Hyperpolarization-Activated Cation Channel
- Cation Channel, Hyperpolarization-Activated
- Channel, Hyperpolarization-Activated Cation
- Hyperpolarization Activated Cation Channel
- HCN Pacemaker Channels
- Channels, HCN Pacemaker
- Pacemaker Channels, HCN
- I(h) Cation Channels
HCN4 Channel- HCN4 Channel
- Channel, HCN4
- Hyperpolarization Cyclic-Nucleotide Gated Cation Channel 4
- Hyperpolarization Cyclic Nucleotide Gated Cation Channel 4
HCN3 Channel- HCN3 Channel
- Channel, HCN3
- Hyperpolarization Cyclic-Nucleotide Gated Cation Channel 3
- Hyperpolarization Cyclic Nucleotide Gated Cation Channel 3
HCN1 Channel- HCN1 Channel
- Channel, HCN1
- Hyperpolarization Cyclic-Nucleotide Gated Cation Channel 1
- Hyperpolarization Cyclic Nucleotide Gated Cation Channel 1
HCN2 Channel- HCN2 Channel
- Channel, HCN2
- Potassium-Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2
- Potassium Sodium Hyperpolarization Activated Cyclic Nucleotide Gated Channel 2
- HCN2 Potassium Channel
- Channel, HCN2 Potassium
- Potassium Channel, HCN2
- Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2
- Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2
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Below are MeSH descriptors whose meaning is more general than "Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels".
Below are MeSH descriptors whose meaning is more specific than "Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels".
This graph shows the total number of publications written about "Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels" by people in this website by year, and whether "Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2001 | 0 | 1 | 1 | | 2002 | 0 | 4 | 4 | | 2004 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 3 | 3 | | 2013 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 | | 2024 | 1 | 0 | 1 | | 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels" by people in Profiles.
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Teichman EM, Hu J, Lin HY, Fisher-Foye RL, Blando A, Hu X, Kaniskan H?, Montgomery SE, Cai M, Parise LF, Wang J, Russo SJ, Han MH, Jin J, Morel C. Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype. Mol Psychiatry. 2025 Sep; 30(9):3937-3950.
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Altman NL, Gill EA, Kahwash R, Meyer LK, Wagner JA, Karimpour-Fard A, Berning AA, Minobe WA, Carroll IA, Jonas ER, Slavov D, Emani S, Abraham WT, Gollah AR, Ellis SL, Taylor MRG, Graw SL, Mestroni L, McKinsey TA, Buttrick PM, Kao DP, Bristow MR. Heart Rate Reduction Is Associated With Reverse Left Ventricular Remodeling and Mechanism-Specific Molecular Phenotypes in Dilated Cardiomyopathy. Circ Heart Fail. 2025 Apr; 18(4):e012484.
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Peters CH, Singh RK, Langley AA, Nichols WG, Ferris HR, Jeffrey DA, Proenza C, Bankston JR. LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction. Elife. 2024 Apr 23; 12.
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Peters CH, Liu PW, Morotti S, Gantz SC, Grandi E, Bean BP, Proenza C. Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes. Proc Natl Acad Sci U S A. 2021 07 13; 118(28).
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Peters CH, Myers ME, Juchno J, Haimbaugh C, Bichraoui H, Du Y, Bankston JR, Walker LA, Proenza C. Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins. Proc Natl Acad Sci U S A. 2020 07 28; 117(30):18079-18090.
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Proenza C. Exploiting natural regulation. Elife. 2018 08 06; 7.
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Bankston JR, DeBerg HA, Stoll S, Zagotta WN. Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b. J Biol Chem. 2017 10 27; 292(43):17794-17803.
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Lin H, Mueller-Nurasyid M, Smith AV, Arking DE, Barnard J, Bartz TM, Lunetta KL, Lohman K, Kleber ME, Lubitz SA, Geelhoed B, Trompet S, Niemeijer MN, Kacprowski T, Chasman DI, Klarin D, Sinner MF, Waldenberger M, Meitinger T, Harris TB, Launer LJ, Soliman EZ, Chen LY, Smith JD, Van Wagoner DR, Rotter JI, Psaty BM, Xie Z, Hendricks AE, Ding J, Delgado GE, Verweij N, van der Harst P, Macfarlane PW, Ford I, Hofman A, Uitterlinden A, Heeringa J, Franco OH, Kors JA, Weiss S, V?lzke H, Rose LM, Natarajan P, Kathiresan S, K??b S, Gudnason V, Alonso A, Chung MK, Heckbert SR, Benjamin EJ, Liu Y, M?rz W, Rienstra M, Jukema JW, Stricker BH, D?rr M, Albert CM, Ellinor PT. Gene-gene Interaction Analyses for Atrial Fibrillation. Sci Rep. 2016 11 08; 6:35371.
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DeBerg HA, Bankston JR, Rosenbaum JC, Brzovic PS, Zagotta WN, Stoll S. Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b. Structure. 2015 Apr 07; 23(4):734-44.
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St Clair JR, Liao Z, Larson ED, Proenza C. PKA-independent activation of I(f) by cAMP in mouse sinoatrial myocytes. Channels (Austin). 2013 Jul-Aug; 7(4):318-21.
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