 Transient Receptor Potential Channels
"Transient Receptor Potential Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
| Descriptor ID |
D050051
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| MeSH Number(s) |
D12.776.157.530.400.901 D12.776.543.585.400.901
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| Concept/Terms |
Transient Receptor Potential Channels- Transient Receptor Potential Channels
- TRP Membrane Proteins
- Membrane Proteins, TRP
- Proteins, TRP Membrane
- TRP Cation Channels
- Cation Channels, TRP
- Channels, TRP Cation
- Transient Receptor Potential Cation Channels
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Below are MeSH descriptors whose meaning is more general than "Transient Receptor Potential Channels".
Below are MeSH descriptors whose meaning is more specific than "Transient Receptor Potential Channels".
This graph shows the total number of publications written about "Transient Receptor Potential Channels" by people in this website by year, and whether "Transient Receptor Potential Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2007 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transient Receptor Potential Channels" by people in Profiles.
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Wang Y, Tan L, Jiao K, Xue C, Tang Q, Jiang S, Ren Y, Chen H, El-Aziz TMA, Abdelazeem KNM, Yu Y, Zhao F, Zhu MX, Cao Z. Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels. Br J Pharmacol. 2022 10; 179(20):4792-4808.
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Minckley TF, Zhang C, Fudge DH, Dischler AM, LeJeune KD, Xu H, Qin Y. Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals. Nat Commun. 2019 10 22; 10(1):4806.
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Craighead DH, Shank SW, Gottschall JS, Passe DH, Murray B, Alexander LM, Kenney WL. Ingestion of transient receptor potential channel agonists attenuates exercise-induced muscle cramps. Muscle Nerve. 2017 09; 56(3):379-385.
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Evans JG, Todorovic SM. Redox and trace metal regulation of ion channels in the pain pathway. Biochem J. 2015 Sep 15; 470(3):275-80.
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Lee JH, McBrayer MK, Wolfe DM, Haslett LJ, Kumar A, Sato Y, Lie PP, Mohan P, Coffey EE, Kompella U, Mitchell CH, Lloyd-Evans E, Nixon RA. Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification. Cell Rep. 2015 Sep 01; 12(9):1430-44.
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Nagatomo K, Ishii H, Yamamoto T, Nakajo K, Kubo Y. The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression. Biophys J. 2010 Dec 01; 99(11):3609-18.
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Lin W, Margolskee R, Donnert G, Hell SW, Restrepo D. Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2471-6.
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