 Transcription Factor 4
"Transcription Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
| Descriptor ID |
D000073940
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| MeSH Number(s) |
D12.776.260.108.092.937 D12.776.930.125.500.937
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| Concept/Terms |
Transcription Factor 4- Transcription Factor 4
- TCF4 Transcription Factor
- Transcription Factor, TCF4
- TCF-4 Transcription Factor
- TCF 4 Transcription Factor
- Transcription Factor, TCF-4
- TCF-4 Protein
- TCF 4 Protein
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Below are MeSH descriptors whose meaning is more general than "Transcription Factor 4".
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This graph shows the total number of publications written about "Transcription Factor 4" by people in this website by year, and whether "Transcription Factor 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Transcription Factor 4" by people in Profiles.
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Geist L, Henen MA, Haiderer S, Schwarz TC, Kurzbach D, Zawadzka-Kazimierczuk A, Saxena S, Zerko S, Kozminski W, Hinderberger D, Konrat R. Protonation-dependent conformational variability of intrinsically disordered proteins. Protein Sci. 2013 Sep; 22(9):1196-205.
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Henthorn P, McCarrick-Walmsley R, Kadesch T. Sequence of the cDNA encoding ITF-2, a positive-acting transcription factor. Nucleic Acids Res. 1990 Feb 11; 18(3):678.
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