 Multifactorial Inheritance
"Multifactorial Inheritance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phenotypic outcome (physical characteristic or disease predisposition) that is determined by more than one gene. Polygenic refers to those determined by many genes, while oligogenic refers to those determined by a few genes.
| Descriptor ID |
D020412
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| MeSH Number(s) |
G05.420.590
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| Concept/Terms |
Multifactorial Inheritance- Multifactorial Inheritance
- Inheritance, Multifactorial
- Inheritances, Multifactorial
- Multifactorial Inheritances
Polygenic Inheritance- Polygenic Inheritance
- Inheritance, Polygenic
- Inheritances, Polygenic
- Polygenic Inheritances
- Polygenic Traits
- Polygenic Trait
- Trait, Polygenic
- Traits, Polygenic
- Polygenic Characters
- Character, Polygenic
- Characters, Polygenic
- Polygenic Character
Oligogenic Inheritance- Oligogenic Inheritance
- Inheritance, Oligogenic
- Inheritances, Oligogenic
- Oligogenic Inheritances
- Oligogenic Traits
- Oligogenic Trait
- Trait, Oligogenic
- Traits, Oligogenic
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Below are MeSH descriptors whose meaning is more general than "Multifactorial Inheritance".
Below are MeSH descriptors whose meaning is more specific than "Multifactorial Inheritance".
This graph shows the total number of publications written about "Multifactorial Inheritance" by people in this website by year, and whether "Multifactorial Inheritance" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 1 | 1 | 2 | | 2008 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 0 | 2 | 2 | | 2012 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 1 | 1 | 2 | | 2015 | 2 | 2 | 4 | | 2016 | 2 | 1 | 3 | | 2017 | 1 | 3 | 4 | | 2018 | 5 | 4 | 9 | | 2019 | 4 | 3 | 7 | | 2020 | 2 | 6 | 8 | | 2021 | 6 | 13 | 19 | | 2022 | 5 | 8 | 13 | | 2023 | 2 | 6 | 8 | | 2024 | 4 | 9 | 13 | | 2025 | 7 | 11 | 18 | | 2026 | 1 | 1 | 2 |
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Below are the most recent publications written about "Multifactorial Inheritance" by people in Profiles.
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Zhang C, Konigsberg IR, He Y, Zhang J, Chikowore T, Feldman WB, Hu X, Ding Y, Pasaniuc B, Chang D, Chen Q, Lasky-Su JA, Hecker J, Tobin MD, Chen J, Kalra S, Pratte KA, Im HK, Wan ES, Manichaikul A, Silverman EK, Bowler RP, Lange LA, Ortega VE, Martin AR, Cho MH, Moll MR. Multi-trait polygenic scores for COPD and COPD exacerbations implicate druggable proteins. JCI Insight. 2026 Apr 08; 11(7).
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Fortis S, Comellas AP, Bowler RP, Bhatt SP, Hersh CP, Demeo DL, Kinney G, Silverman EK, Cho MH, Moll M. Relationships between bronchodilator responsiveness, a COPD polygenic risk score, and COPD progression. Respir Med. 2026 02; 252:108636.
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Small AM, Yang TY, Itoh S, Thériault S, Dufresne L, Kurosawa R, Komuro I, Matsuda K, Vy HMT, Farber-Eger EH, Shaffer LL, Boulier KM, Corey KM, Ramaker ME, Laporte F, Schott JJ, Le Scouarnec S, Singh SA, Sonawane AR, Smith HA, Rafaels N, Ghouse J, Raja AA, Ostrowski SR, Sørensen E, Mikkelsen C, Pedersen OB, Erikstrup C, Ullum H, Sveinbjornsson G, Gudbjartsson DF, Abner E, Lee J, Ganna A, Nowak-Göttl U, Finer S, Schumacher J, Maj C, Al-Kassou B, Nickenig G, Trenkwalder T, Dreßen M, Krane M, Nöthen MM, Moksnes MR, Brumpton BM, Knight S, Knowlton KU, Nadauld L, Debiec R, Musameh MD, Braund PS, Nelson CP, Czuba T, Melander O, Selvaraj MS, Koyama S, Bhukar R, Ruan Y, Ljungberg J, Damrauer SM, Levin MG, Franke A, Berger K, Ruff CT, Melloni GEM, Kamanu FK, Ito K, Do R, Loos RJF, Schunkert H, Wells QS, Shah SH, Le Tourneau T, Messika-Zeitoun D, Gignoux C, Bundgaard H, Larsson SC, Michaëlsson K, Holm H, Helgadottir A, Esko T, van Heel DA, Mathieu P, Samani NJ, Smith JG, Söderberg S, Rader DJ, Marston NA, Sabatine MS, Pasaniuc B, Cho K, Wilson PWF, O'Donnell CJ, Stefansson K, Bossé Y, Aikawa E, Engert JC, Peloso GM, Natarajan P, Thanassoulis G. Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction. Nat Genet. 2026 Jan; 58(1):57-66.
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Natarajan R, Szczesny B, Kanchan K, Esquinca E, Boorgula MP, Chavan S, Campbell M, Lorizio W, Doumatey AP, Cruz AA, Watson H, Naureckas ET, Giles BL, Arinola G, Sogaolu O, Falade AG, Hansel NN, Olopade CO, Rotimi CN, Landis RC, Figueiredo CA, Kenny EE, Ruczinski I, Liu AH, Ober C, Taub MA, Johnson RK, Barnes KC, Wojcik GL, Mathias RA. Mediation of Polygenic Asthma Risk Through Gene Expression. Allergy. 2026 Apr; 81(4):1089-1098.
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Thorpe HHA, Cupertino RB, Pakala SR, Fontanillas P, Jennings MV, Yang J, Meredith JJ, Greenwood T, Bianchi SB, Vilar-Ribó L, Niarchou M, Elson SL, Ideker T, Davis LK, MacKillop J, deWit H, Gustavson DE, Mallard TT, Palmer AA, Sanchez-Roige S. Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health. Mol Psychiatry. 2026 Apr; 31(4):2081-2093.
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Smith JL, Adebamowo CA, Adebamowo SN, Darst BF, Fullerton SM, Gogarten SM, Hamed ME, Hirbo JB, Hysong MR, Johar AS, Khan AT, Kullo IJ, Konigsberg IR, Kraft P, Lange LA, Li Y, Martin AR, Nelson SC, Choudhury A, Ramsay M, Cobran EK, Schaid DJ, Sharma J, Wang Y, Wojcik GL, Sun Q. Recommendations for responsible use of population descriptors in polygenic risk score development. Nat Genet. 2025 Dec; 57(12):2962-2971.
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Jiang SJ, Thomas M, Rosenthal EA, Phipps AI, Sakoda LC, van Duijnhoven FJB, Pellatt AJ, Avery CL, Berndt SI, Bishop DT, Castellví-Bel S, Chan AT, Grant RC, Gignoux C, Gsur A, Gunter MJ, Haiman CA, Hoffmeister M, Jarvik GP, Jenkins MA, Keku TO, Küry S, Lee JK, Marchand LL, Moreno V, Newcomb PA, Newton CC, Ogino S, Palmer JR, Pearlman R, Qu C, Schoen RE, Um CY, Van Guelpen B, Visvanathan K, Vymetalkova V, White E, Woods MO, Platz EA, Brenner H, Corley DA, Vogelaar IL, Hsu L, Peters U. Multiple polygenic score approach in colorectal cancer risk prediction. Sci Rep. 2025 Oct 30; 15(1):38006.
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Mallard TT, Tubbs JD, Jennings M, Zhang Y, Gustavson DE, Grotzinger AD, Westwater ML, Williams CM, Fortgang RG, Elson SL, Fontanillas P, Davis LK, Raznahan A, Tucker-Drob EM, Choi KW, Ge T, Smoller JW, Palmer AA, Sanchez-Roige S. Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment. Am J Psychiatry. 2026 Jan 01; 183(1):31-47.
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Qian ?? Y, Xia ??? J, Wang ??? P, Xie C, Lin ??? HL, Li GH, Yuan ??? CD, Qiu ??? MC, Fang ??? YH, Yu ??? CF, Cai ??? XC, Khederzadeh S, Zhao ??? PP, Yang ??? MY, Zhong ??? JD, Li ?? X, Guan ??? PL, Gu ??? JX, Gai ??? SR, Yi ??? XJ, Tao ??? JG, Chen ?? X, Miao ??? MM, Chen ??? GB, Xu ?? L, Xie ??? SY, Tian ?? G, Yue ?? H, Li ??? G, Xiao ??? W, Karasik D, Xu ??? Y, Yang ?? L, Cheung CL, Huang ?? F, Zhang ??? Z, Zheng ??? HF. Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance. Genomics Proteomics Bioinformatics. 2025 Oct 28; 23(5).
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van der Laan CM, Ip HF, Schipper M, Hottenga JJ, St Pourcain B, Zayats T, Pool R, Krapohl EML, Brikell I, Soler Artigas M, Cabana-Domínguez J, Llonga N, Nolte IM, Bolhuis K, Palviainen T, Zafarmand H, Gordon S, Aliev F, Burt SA, Wang CA, Saunders G, Karhunen V, Adkins DE, Border R, Peterson RE, Prinz JA, Thiering E, Vilor-Tejedor N, Ahluwalia TS, Allegrini A, Rimfeld K, Chen Q, Lu Y, Martin J, Bosch R, Ramos-Quiroga JA, Neumann A, Ensink J, Grasby KL, Morosoli JJ, Tong X, Marrington S, Scott JG, Shabalin AA, Corley R, Evans LM, Sugden K, Alemany S, Sass L, Vinding R, Ehli EA, Hagenbeek FA, Derks EM, Larsson H, Snieder H, Cecil C, Whipp AM, Korhonen T, Vuoksimaa E, Rose RJ, Uitterlinden AG, Haavik J, Harris JR, Helgeland Ø, Johansson S, Knudsen GPS, Njolstad PR, Lu Q, Rodriguez A, Henders AK, Mamun A, Najman JM, Brown S, Hopfer C, Krauter K, Reynolds CA, Smolen A, Stallings M, Wadsworth S, Wall TL, Eaves L, Silberg JL, Miller A, Havdahl A, Llop S, Lopez-Espinosa MJ, Bønnelykke K, Sunyer J, Arseneault L, Standl M, Heinrich J, Boden J, Pearson J, Horwood J, Kennedy M, Poulton R, Maes HH, Hewitt J, Copeland WE, Middeldorp CM, Williams GM, Wray N, Järvelin MR, McGue M, Iacono W, Caspi A, Moffitt TE, Whitehouse AJO, Pennell CE, Klump KL, Jiang C, Dick DM, Reichborn-Kjennerud T, Martin NG, Medland SE, Vrijkotte T, Kaprio J, Tiemeier H, Davey Smith G, Hartman CA, Oldehinkel AJ, Casas M, Ribasés M, Lichtenstein P, Lundström S, Plomin R, Bartels M, Nivard MG, Boomsma DI. Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes. Nat Genet. 2025 Oct; 57(10):2427-2435.
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