 Apelin
"Apelin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 77 amino acid secreted endogenous ligand for the angiotensin II receptor-like 1 protein (APELIN RECEPTOR) that is proteolytically cleaved into four smaller peptides: Apelin-36, Apelin-31, Apelin-28, and Apelin-13. It inhibits entry of HIV into cells that express both APJ and CD4 ANTIGEN and is highly expressed in breast milk, where it may modulate the neonatal immune response.
| Descriptor ID |
D000073861
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| MeSH Number(s) |
D12.644.276.150 D23.529.134
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apelin".
Below are MeSH descriptors whose meaning is more specific than "Apelin".
This graph shows the total number of publications written about "Apelin" by people in this website by year, and whether "Apelin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apelin" by people in Profiles.
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McKenna CF, Salvador AF, Keeble AR, Khan NA, De Lisio M, Konopka AR, Paluska SA, Burd NA. Muscle strength after resistance training correlates to mediators of muscle mass and mitochondrial respiration in middle-aged adults. J Appl Physiol (1985). 2022 09 01; 133(3):572-584.
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Frump AL, Albrecht M, Yakubov B, Breuils-Bonnet S, Nadeau V, Tremblay E, Potus F, Omura J, Cook T, Fisher A, Rodriguez B, Brown RD, Stenmark KR, Rubinstein CD, Krentz K, Tabima DM, Li R, Sun X, Chesler NC, Provencher S, Bonnet S, Lahm T. 17?-Estradiol and estrogen receptor a protect right ventricular function in pulmonary hypertension via BMPR2 and apelin. J Clin Invest. 2021 03 15; 131(6).
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Vaughan OR, Powell TL, Jansson T. Apelin is a novel regulator of human trophoblast amino acid transport. Am J Physiol Endocrinol Metab. 2019 05 01; 316(5):E810-E816.
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Neto-Neves EM, Frump AL, Vayl A, Kline JA, Lahm T. Isolated heart model demonstrates evidence of contractile and diastolic dysfunction in right ventricles from rats with sugen/hypoxia-induced pulmonary hypertension. Physiol Rep. 2017 Oct; 5(19).
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Frump AL, Goss KN, Vayl A, Albrecht M, Fisher A, Tursunova R, Fierst J, Whitson J, Cucci AR, Brown MB, Lahm T. Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones. Am J Physiol Lung Cell Mol Physiol. 2015 May 01; 308(9):L873-90.
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Smith TP, Schlenz AM, Schatz JC, Maitra R, Sweitzer SM. Modulation of pain in pediatric sickle cell disease: understanding the balance between endothelin mediated vasoconstriction and apelin mediated vasodilation. Blood Cells Mol Dis. 2015 Feb; 54(2):155-9.
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Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2014 08; 124(8):3514-28.
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O'Donnell LA, Agrawal A, Sabnekar P, Dichter MA, Lynch DR, Kolson DL. Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury. J Neurochem. 2007 Sep; 102(6):1905-1917.
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Puffer BA, Sharron M, Coughlan CM, Baribaud F, McManus CM, Lee B, David J, Price K, Horuk R, Tsang M, Doms RW. Expression and coreceptor function of APJ for primate immunodeficiency viruses. Virology. 2000 Oct 25; 276(2):435-44.
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