 Agouti Signaling Protein
"Agouti Signaling Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.
| Descriptor ID |
D054366
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| MeSH Number(s) |
D12.644.276.049 D12.776.467.049 D23.529.049
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Agouti Signaling Protein".
Below are MeSH descriptors whose meaning is more specific than "Agouti Signaling Protein".
This graph shows the total number of publications written about "Agouti Signaling Protein" by people in this website by year, and whether "Agouti Signaling Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Agouti Signaling Protein" by people in Profiles.
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Ferreira MS, Thurman TJ, Jones MR, Farelo L, Kumar AV, Mortimer SME, Demboski JR, Mills LS, Alves PC, Melo-Ferreira J, Good JM. The evolution of white-tailed jackrabbit camouflage in response to past and future seasonal climates. Science. 2023 03 24; 379(6638):1238-1242.
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Miyazaki M, Sampath H, Liu X, Flowers MT, Chu K, Dobrzyn A, Ntambi JM. Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun. 2009 Mar 20; 380(4):818-22.
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Badger TM, Ronis MJ, Wolff G, Stanley S, Ferguson M, Shankar K, Simpson P, Jo CH. Soy protein isolate reduces hepatosteatosis in yellow Avy/a mice without altering coat color phenotype. Exp Biol Med (Maywood). 2008 Oct; 233(10):1242-54.
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Voisey J, Box NF, van Daal A. A polymorphism study of the human Agouti gene and its association with MC1R. Pigment Cell Res. 2001 Aug; 14(4):264-7.
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