Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Aleksandra Wierzba

TitleResearch Associate
InstitutionUniversity of Colorado Boulder
DepartmentBiofrontiers Institute

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Olenginski LT, Patel D, Wierzba AJ, Batey RT. Reimagining productive chemical space for RNA recognition beyond aromaticity. bioRxiv. 2026 Aug 11. PMID: 42845543.
      View in: PubMed
    2. Wierzba AJ, Richards EM, Lennon SR, Batey RT, Palmer AE. Enhancement of RNA Imaging Platforms by the Use of Peptide Nucleic Acid-Based Linkers. Bio Protoc. 2026 Jun 20; 16(12):e5453. PMID: 42367207.
      View in: PubMed
    3. Machalska E, Mazzeo G, Wierzba AJ, Dybas J, Rode JE, Abbate S, Gryko D, Baranska M, Longhi G, Fusè M. Monitoring the Switching from Base-on to Base-off Forms of Vitamin B12 by Natural and Magnetic Circular Dichroism Spectroscopies. Anal Chem. 2026 02 10; 98(5):3466-3473. PMID: 41615889.
      View in: PubMed
    4. Olenginski LT, Wierzba AJ, Laursen SP, Batey RT. Designing small molecules targeting a cryptic RNA binding site through base displacement. Nat Chem Biol. 2026 Jun; 22(6):1004-1013. PMID: 40883492.
      View in: PubMed
    5. Siwik SH, Wierzba AJ, Lennon SR, Olenginski LT, Palmer AE, Batey RT. Structural basis for ring-opening fluorescence by the RhoBAST RNA aptamer. Nucleic Acids Res. 2025 06 20; 53(12). PMID: 40598898.
      View in: PubMed
    6. Batey R, Olenginski L, Wierzba A, Laursen S. Designing small molecules that target a cryptic RNA binding site via base displacement. Res Sq. 2025 Jan 29. PMID: 39975918.
      View in: PubMed
    7. Siwik SH, Wierzba AJ, Lennon SR, Olenginski LT, Palmer AE, Batey RT. Structural basis for ring-opening fluorescence by the RhoBAST RNA aptamer. bioRxiv. 2024 Dec 30. PMID: 39803439.
      View in: PubMed
    8. Wierzba AJ, Richards EM, Lennon SR, Batey RT, Palmer AE. Unveiling the promise of peptide nucleic acids as functional linkers for an RNA imaging platform. RSC Chem Biol. 2025 Feb 05; 6(2):249-262. PMID: 39759445.
      View in: PubMed
    9. Govindharaj P, Wierzba AJ, Keska K, Kochman MA, Wiosna-Salyga G, Kubas A, Data P, Lindner M. Regioisomerism vs Conformation: Impact of Molecular Design on the Emission Pathway in Organic Light-Emitting Device Emitters. ACS Appl Mater Interfaces. 2024 May 08; 16(18):23654-23667. PMID: 38668584.
      View in: PubMed
    10. Lennon SR, Wierzba AJ, Siwik SH, Gryko D, Palmer AE, Batey RT. Targeting Riboswitches with Beta-Axial-Substituted Cobalamins. ACS Chem Biol. 2023 05 19; 18(5):1136-1147. PMID: 37094176.
      View in: PubMed
    11. Rybicka-Jasinska K, Wdowik T, Luczak K, Wierzba AJ, Drapala O, Gryko D. Porphyrins as Promising Photocatalysts for Red-Light-Induced Functionalizations of Biomolecules. ACS Org Inorg Au. 2022 Oct 05; 2(5):422-426. PMID: 36855670.
      View in: PubMed
    12. Machalska E, Zajac G, Wierzba AJ, Kapitán J, Andruniów T, Spiegel M, Gryko D, Bour P, Baranska M. Recognition of the True and False Resonance Raman Optical Activity. Angew Chem Int Ed Engl. 2021 09 20; 60(39):21205-21210. PMID: 34216087.
      View in: PubMed
    13. Pienko T, Czarnecki J, Równicki M, Wojciechowska M, Wierzba AJ, Gryko D, Bartosik D, Trylska J. Vitamin B12-peptide nucleic acids use the BtuB receptor to pass through the Escherichia coli outer membrane. Biophys J. 2021 02 16; 120(4):725-737. PMID: 33453274.
      View in: PubMed
    14. Wierzba AJ, Wojciechowska M, Trylska J, Gryko D. Vitamin B12 - Peptide Nucleic Acid Conjugates. Methods Mol Biol. 2021; 2355:65-82. PMID: 34386951.
      View in: PubMed
    15. Machalska E, Zajac G, Halat M, Wierzba AJ, Gryko D, Baranska M. Resonance Raman Optical Activity Spectroscopy in Probing Structural Changes Invisible to Circular Dichroism Spectroscopy: A Study on Truncated Vitamin B12 Derivatives. Molecules. 2020 Sep 24; 25(19). PMID: 32987678.
      View in: PubMed
    16. Borner T, Workinger JL, Tinsley IC, Fortin SM, Stein LM, Chepurny OG, Holz GG, Wierzba AJ, Gryko D, Nexø E, Shaulson ED, Bamezai A, Da Silva VAR, De Jonghe BC, Hayes MR, Doyle RP. Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis. Cell Rep. 2020 06 16; 31(11):107768. PMID: 32553160.
      View in: PubMed
    17. Ociepa M, Wierzba AJ, Turkowska J, Gryko D. Polarity-Reversal Strategy for the Functionalization of Electrophilic Strained Molecules via Light-Driven Cobalt Catalysis. J Am Chem Soc. 2020 03 18; 142(11):5355-5361. PMID: 32105464.
      View in: PubMed
    18. Wierzba AJ, Maximova K, Wincenciuk A, Równicki M, Wojciechowska M, Nexø E, Trylska J, Gryko D. Does a Conjugation Site Affect Transport of Vitamin B12 -Peptide Nucleic Acid Conjugates into Bacterial Cells? Chemistry. 2018 Dec 12; 24(70):18772-18778. PMID: 30286265.
      View in: PubMed
    19. Braselmann E, Wierzba AJ, Polaski JT, Chrominski M, Holmes ZE, Hung ST, Batan D, Wheeler JR, Parker R, Jimenez R, Gryko D, Batey RT, Palmer AE. A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells. Nat Chem Biol. 2018 10; 14(10):964-971. PMID: 30061719.
      View in: PubMed
    20. Wierzba AJ, Wincenciuk A, Karczewski M, Vullev VI, Gryko D. meso-Modified Cobalamins: Synthesis, Structure, and Properties. Chemistry. 2018 Jul 20; 24(41):10344-10356. PMID: 29719071.
      View in: PubMed
    21. Równicki M, Wojciechowska M, Wierzba AJ, Czarnecki J, Bartosik D, Gryko D, Trylska J. Vitamin B12 as a carrier of peptide nucleic acid (PNA) into bacterial cells. Sci Rep. 2017 08 09; 7(1):7644. PMID: 28794451.
      View in: PubMed
    22. Pienko T, Wierzba AJ, Wojciechowska M, Gryko D, Trylska J. Conformational Dynamics of Cyanocobalamin and Its Conjugates with Peptide Nucleic Acids. J Phys Chem B. 2017 04 13; 121(14):2968-2979. PMID: 28301169.
      View in: PubMed
    23. Wierzba A, Wojciechowska M, Trylska J, Gryko D. Vitamin B12 Suitably Tailored for Disulfide-Based Conjugation. Bioconjug Chem. 2016 Jan 20; 27(1):189-97. PMID: 26693734.
      View in: PubMed
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