 MEF2 Transcription Factors
"MEF2 Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Activating transcription factors of the MADS family which bind a specific sequence element (MEF2 element) in many muscle-specific genes and are involved in skeletal and cardiac myogenesis, neuronal differentiation and survival/apoptosis.
| Descriptor ID |
D064326
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| MeSH Number(s) |
D12.776.210.500.570.294 D12.776.260.103.750.294 D12.776.260.400.249.624 D12.776.930.125.750.294 D12.776.930.397.700
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| Concept/Terms |
MEF2 Transcription Factors- MEF2 Transcription Factors
- Transcription Factors, MEF2
- Muscle Enhancer Factor-2
- Enhancer Factor-2, Muscle
- Muscle Enhancer Factor 2
- Myocyte-Specific Enhancer-Binding Factor 2
- Myocyte Specific Enhancer Binding Factor 2
- Myocyte Enhancer Factor 2
- Myocyte-Specific Enhancer Factor 2
- Myocyte Specific Enhancer Factor 2
- MEF2 Proteins
- Muscle-Specific Enhancer Factor-2
- Enhancer Factor-2, Muscle-Specific
- Muscle Specific Enhancer Factor 2
MEF2B Transcription Factor- MEF2B Transcription Factor
- Transcription Factor, MEF2B
- Serum Response Factor-Like Protein 2
- Serum Response Factor Like Protein 2
- Myocyte-Specific Enhancer Factor 2B
- Myocyte Specific Enhancer Factor 2B
- Muscle Enhancer Factor-2B
- Enhancer Factor-2B, Muscle
- Muscle Enhancer Factor 2B
- Muscle-Specific Enhancer Factor-2B
- Enhancer Factor-2B, Muscle-Specific
- Muscle Specific Enhancer Factor 2B
- Myocyte Enhancer Factor 2B
- Myocyte-Specific Enhancer-Binding Factor 2B
- Myocyte Specific Enhancer Binding Factor 2B
- MEF2B Protein
MEF2D Transcription Factor- MEF2D Transcription Factor
- Transcription Factor, MEF2D
- Muscle Enhancer Factor-2D
- Enhancer Factor-2D, Muscle
- Muscle Enhancer Factor 2D
- Muscle-Specific Enhancer Factor-2D
- Enhancer Factor-2D, Muscle-Specific
- Muscle Specific Enhancer Factor 2D
- Myocyte-Specific Enhancer Factor 2D
- Myocyte Specific Enhancer Factor 2D
- Myocyte-Specific Enhancer-Binding Factor 2D
- Myocyte Specific Enhancer Binding Factor 2D
- MEF2D Protein
- Myocyte Enhancer Factor 2D
MEF2A Transcription Factor- MEF2A Transcription Factor
- Transcription Factor, MEF2A
- Muscle Enhancer Factor-2A
- Enhancer Factor-2A, Muscle
- Muscle Enhancer Factor 2A
- Serum Response Factor-Like Protein 1
- Serum Response Factor Like Protein 1
- Myocyte Enhancer Factor 2A
- Myocyte-Specific Enhancer Factor 2A
- Myocyte Specific Enhancer Factor 2A
- Myocyte-Specific Enhancer-Binding Factor 2A
- Myocyte Specific Enhancer Binding Factor 2A
- MEF2A Protein
- Muscle-Specific Enhancer Factor-2A
- Enhancer Factor-2A, Muscle-Specific
- Muscle Specific Enhancer Factor 2A
MEF2C Transcription Factor- MEF2C Transcription Factor
- Transcription Factor, MEF2C
- Muscle Enhancer Factor-2C
- Enhancer Factor-2C, Muscle
- Muscle Enhancer Factor 2C
- Myocyte-Specific Enhancer-Binding Factor 2C
- Myocyte Specific Enhancer Binding Factor 2C
- Myocyte Enhancer Factor 2C
- Myocyte-Specific Enhancer Factor 2C
- Myocyte Specific Enhancer Factor 2C
- MEF2C Protein
- Muscle-Specific Enhancer Factor-2C
- Enhancer Factor-2C, Muscle-Specific
- Muscle Specific Enhancer Factor 2C
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Below are MeSH descriptors whose meaning is more general than "MEF2 Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "MEF2 Transcription Factors".
This graph shows the total number of publications written about "MEF2 Transcription Factors" by people in this website by year, and whether "MEF2 Transcription Factors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2000 | 0 | 8 | 8 | | 2001 | 0 | 2 | 2 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 3 | 3 | | 2004 | 0 | 2 | 2 | | 2005 | 0 | 4 | 4 | | 2006 | 0 | 4 | 4 | | 2007 | 0 | 3 | 3 | | 2008 | 0 | 3 | 3 | | 2009 | 0 | 2 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 1 | 2 | 3 | | 2018 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 | | 2022 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "MEF2 Transcription Factors" by people in Profiles.
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Bailon-Zambrano R, Sucharov J, Mumme-Monheit A, Murry M, Stenzel A, Pulvino AT, Mitchell JM, Colborn KL, Nichols JT. Variable paralog expression underlies phenotype variation. Elife. 2022 09 22; 11.
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Travers JG, Hu T, McKinsey TA. The black sheep of class IIa: HDAC7 SIKens the heart. J Clin Invest. 2020 06 01; 130(6):2811-2813.
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Judge SM, Deyhle MR, Neyroud D, Nosacka RL, D'Lugos AC, Cameron ME, Vohra RS, Smuder AJ, Roberts BM, Callaway CS, Underwood PW, Chrzanowski SM, Batra A, Murphy ME, Heaven JD, Walter GA, Trevino JG, Judge AR. MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer. Cancer Res. 2020 05 01; 80(9):1861-1874.
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Sucharov J, Ray K, Brooks EP, Nichols JT. Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway. PLoS Genet. 2019 12; 15(12):e1008507.
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Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, Hall D, Wu J, Shi Y, Zhu Q, Chen C, Thiel WH, Zhan X, Weiss RM, Zhan F, Musselman CA, Pufall M, Zhu W, Au KF, Hong J, Anderson ME, Grueter CE, Song LS. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018 12 21; 362(6421).
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Hsu YH, Li G, Liu CT, Brody JA, Karasik D, Chou WC, Demissie S, Nandakumar K, Zhou Y, Cheng CH, Gill R, Gibbs RA, Muzny D, Santibanez J, Estrada K, Rivadeneira F, Harris T, Gudnason V, Uitterlinden A, Psaty BM, Robbins JA, Adrienne Cupples L, Kiel DP. Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. Hum Mol Genet. 2016 12 01; 25(23):5234-5243.
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Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey RC, McCastlain K, Reshmi SC, Payne-Turner D, Iacobucci I, Shao Y, Chen IM, Valentine M, Pei D, Mungall KL, Mungall AJ, Ma Y, Moore R, Marra M, Stonerock E, Gastier-Foster JM, Devidas M, Dai Y, Wood B, Borowitz M, Larsen EE, Maloney K, Mattano LA, Angiolillo A, Salzer WL, Burke MJ, Gianni F, Spinelli O, Radich JP, Minden MD, Moorman AV, Patel B, Fielding AK, Rowe JM, Luger SM, Bhatia R, Aldoss I, Forman SJ, Kohlschmidt J, Mr?zek K, Marcucci G, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Paietta E, Willman CL, Loh ML, Hunger SP, Mullighan CG. Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia. Nat Commun. 2016 11 08; 7:13331.
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Nichols JT, Blanco-S?nchez B, Brooks EP, Parthasarathy R, Dowd J, Subramanian A, Nachtrab G, Poss KD, Schilling TF, Kimmel CB. Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. Development. 2016 12 01; 143(23):4430-4440.
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Zhao Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O'Rourke R, Jones KL, Jeong MY, Walker LA, Buttrick PM, McKinsey TA, Song K. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun. 2015 Sep 10; 6:8243.
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Backs J, Worst BC, Lehmann LH, Patrick DM, Jebessa Z, Kreusser MM, Sun Q, Chen L, Heft C, Katus HA, Olson EN. Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4. J Cell Biol. 2011 Oct 31; 195(3):403-15.
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