 Mucosal-Associated Invariant T Cells
"Mucosal-Associated Invariant T Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subset of T-lymphocytes that are present in large numbers at MUCOUS MEMBRANES and respond to INFECTIONS. They express a conserved invariant T-CELL RECEPTOR ALPHA-CHAIN that enables them to respond to infections by sensing RIBOFLAVIN metabolites of pathogens.
| Descriptor ID |
D000072336
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| MeSH Number(s) |
A11.118.637.555.567.550.500.100 A11.118.637.555.567.569.500.100 A15.145.229.637.555.567.550.500.100 A15.145.229.637.555.567.569.500.100 A15.382.490.555.567.550.500.100 A15.382.490.555.567.569.500.100
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Mucosal-Associated Invariant T Cells".
Below are MeSH descriptors whose meaning is more specific than "Mucosal-Associated Invariant T Cells".
This graph shows the total number of publications written about "Mucosal-Associated Invariant T Cells" by people in this website by year, and whether "Mucosal-Associated Invariant T Cells" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2016 | 2 | 0 | 2 | | 2018 | 2 | 1 | 3 | | 2019 | 1 | 0 | 1 | | 2020 | 3 | 1 | 4 | | 2021 | 2 | 0 | 2 | | 2022 | 3 | 0 | 3 | | 2024 | 1 | 0 | 1 | | 2025 | 3 | 0 | 3 |
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Below are the most recent publications written about "Mucosal-Associated Invariant T Cells" by people in Profiles.
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Loh L, Orlicky DJ, Spengler A, Domenico J, Klarquist J, Levens C, Celli S, Kofonow JM, Robertson CE, Lantz O, Legoux F, Frank DN, Matsuda J, Norman PJ, Kuhn KA, Onyiah J, Gapin L. MAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitis. Mucosal Immunol. 2025 Aug; 18(4):958-972.
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Tajpara P, Sobkowiak MJ, Healy K, Naud S, Gündel B, Halimi A, Khan ZA, Gabarrini G, Le Guyader S, Imreh G, Reisz JA, Del Chiaro M, D'Alessandro A, Heuchel R, Löhr JM, Özenci V, Sällberg Chen M. Patient-derived pancreatic tumor bacteria exhibit oncogenic properties and are recognized by MAIT cells in tumor spheroids. Front Immunol. 2025; 16:1553034.
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Uzen R, Bayram F, Dursun H, Kardas F, Cakir M, Cucer N, Eken A, Donmez-Altuntas H. The number and frequency of mucosal-associated invariant T (MAIT), ?d T, and innate lymphoid cells (ILCs) altered in patients with type I Gaucher disease. Hum Immunol. 2025 May; 86(3):111302.
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Tobin R, Katsnelson EN, Couts KL, Spengler A, Loh L, Gapin L, McCarter MD. YIA24-005: MAIT Cells are Reduced in Anorectal Mucosal Melanomas Compared to Cutaneous Melanoma GI Metastases. J Natl Compr Canc Netw. 2024 Apr 05; 22(2.5).
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Gallagher C, Mahon JM, O'Neill C, Cassidy FC, Dunbar H, De Barra C, Cadden C, Pisarska MM, Wood NAW, Masterson JC, McNamee EN, Schrumpf E, English K, O'Shea D, Tobin AM, Hogan AE. Mucosal-Associated Invariant T Cells Are Altered in Patients with Hidradenitis Suppurativa and Contribute to the Inflammatory Milieu. J Invest Dermatol. 2023 06; 143(6):1094-1097.e2.
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Krovi SH, Loh L, Spengler A, Brunetti T, Gapin L. Current insights in mouse iNKT and MAIT cell development using single cell transcriptomics data. Semin Immunol. 2022 03; 60:101658.
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Suliman S, Kjer-Nielsen L, Iwany SK, Lopez Tamara K, Loh L, Grzelak L, Kedzierska K, Ocampo TA, Corbett AJ, McCluskey J, Rossjohn J, León SR, Calderon R, Lecca-Garcia L, Murray MB, Moody DB, Van Rhijn I. Dual TCR-a Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation. J Immunol. 2022 03 15; 208(6):1389-1395.
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Zimmer CL, Filipovic I, Cornillet M, O'Rourke CJ, Berglin L, Jansson H, Sun D, Strauss O, Hertwig L, Johansson H, von Seth E, Sparrelid E, Dias J, Glaumann H, Melum E, Ellis EC, Sandberg JK, Andersen JB, Bergquist A, Björkström NK. Mucosal-associated invariant T-cell tumor infiltration predicts long-term survival in cholangiocarcinoma. Hepatology. 2022 05; 75(5):1154-1168.
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Ozkaya M, Baykan A, Cakir M, Vural C, Sunkak S, Unal E, Eken A. The number and activity of CD3+TCR Va7.2+CD161+ cells are increased in children with acute rheumatic fever. Int J Cardiol. 2021 06 15; 333:174-183.
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Harsha Krovi S, Zhang J, Michaels-Foster MJ, Brunetti T, Loh L, Scott-Browne J, Gapin L. Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells. Nat Commun. 2020 12 07; 11(1):6238.
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