Edwin F deZoeten
Title | Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-PEDS |
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Phone | 720/777-5440 |
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ORCID
.gif) | 0000-0002-0946-9759  |
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Title | Director-Faculty |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-PEDS |
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Division | Gastro |
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Biography University of Wisconsin, Madison, WI | B.S. | 5/1992 | Bacteriology | University of Illinois, Chicago, IL | M.D., Ph.D. | 05/2001 | Medicine | University of Illinois, Chicago, IL | Ph.D. | 05/2001 | Immunology | University of Colorado-SOM, Denver | Resident | 06/2004 | Pediatrics | Children's Hospital Of Philadelphia, Philadelphia, PA | Fellow | 06/2007 | Pediatric GI, Hepatology and Nutrition |
Overview Research 878373 (Albenberg)Jan 1, 2022 - Dec 31, 2024 Crohns and Colitis Foundation The Safety and Effectiveness of anti-TNF therapy in Internally Penetrating Crohn’s Disease Role: Co-investigator |
| W81XWH-21-1-0312 (Edwin de Zoeten)Jul 1, 2021 - Jun 1, 2025 Department of Defense DEFINING A NOVEL THERAPEUTIC APPLICATION OF LACTOFERRIN FOR INTESTINAL INFLAMMATION Role: PI |
| CAPTURE IBD (Edwin de Zoeten)Jan 1, 2021 - Dec 31, 2025 Crohns and Colitis Foundation CAPTURE IBD |
| R01DK111856 (DE ZOETEN, EDWIN FULCO)Jan 13, 2018 - Dec 31, 2023 NIH microRNA-dependent regulation of intestinal T-cells² Role: Co-Principal Investigator |
| K08DK080189 (DE ZOETEN, EDWIN FULCO)Jul 1, 2008 - Jun 30, 2013 NIH Histone Deacetylase Inhibitors and Inflammatory Bowel Disease Role: Principal Investigator |
| T32DK067009 (SOKOL, RONALD J.)Jan 1, 2004 - Jun 30, 2025 NIH Institutional Training Grant in Pediatric Gastroenterology Role: Co-Investigator |
Bibliographic
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Hall CHT, de Zoeten EF. Understanding very early onset inflammatory bowel disease (VEOIBD) in relation to inborn errors of immunity. Immunol Rev. 2024 03; 322(1):329-338. PMID: 38115672.
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Collins CB, Nguyen TT, Leddy RS, Alula KM, Yeckes AR, Strassheim D, Aherne CM, Luck ME, Karoor V, Jedlicka P, Pierce A, de Zoeten EF. Heat shock factor 1 drives regulatory T-cell induction to limit murine intestinal inflammation. Mucosal Immunol. 2024 Feb; 17(1):94-110. PMID: 37944754.
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Constant BD, Albenberg L, Mitchel EB, De Zoeten EF, Clapp JT, Scott FI. Prior Authorizations Delay Therapy, Impact Decision-making, and Lead to Adverse Events in Inflammatory Bowel Disease: 2022 Provider Survey. Clin Gastroenterol Hepatol. 2024 02; 22(2):423-426. PMID: 37394025.
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Hsieh EW, Snapper SB, de Zoeten EF. Editorial: Inborn errors of immunity and mucosal immunity. Front Immunol. 2023; 14:1208798. PMID: 37228613.
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Steiner CA, Koch SD, Evanoff T, Welch N, Kostelecky R, Callahan R, Murphy EM, Nguyen TT, Hall CHT, Lu S, de Zoeten EF, Weiser-Evans MCM, Cartwright IM, Colgan SP. The TNF?ARE Mouse as a Model of Intestinal Fibrosis. Am J Pathol. 2023 08; 193(8):1013-1028. PMID: 37169343.
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White S, Morrow R, Pan I, de Zoeten EF. Riding the Wave of Adalimumab Biosimilars: Considerations for Pediatric Gastroenterologists. J Pediatr Gastroenterol Nutr. 2023 06; 76(6):701-703. PMID: 36867849.
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McLaughlin L, DeZoeten E, Verneris MR. Can allogeneic haematopoietic cell transplantation be curative in classical Crohn's disease? Br J Haematol. 2023 03; 200(5):541-542. PMID: 36352551.
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Cheung T, de Zoeten EF, Hoffenberg EJ, Liu E, Pan Z, Walker T, Stahl M. Characteristics of Children With Inflammatory Bowel Disease and Coexisting Celiac Disease Seropositivity. J Pediatr Gastroenterol Nutr. 2022 12 01; 75(6):737-742. PMID: 36122373.
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Constant BD, de Zoeten EF, Weinman JP, Albenberg L, Scott FI. Early Anti-Tumor-Necrosis-Factor Therapy for Crohn's Disease-Related Abdominal Abscesses and Phlegmon in Children. Dig Dis Sci. 2023 03; 68(3):877-888. PMID: 35790702.
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Nicholson MR, Alexander E, Ballal S, Davidovics Z, Docktor M, Dole M, Gisser JM, Goyal A, Hourigan SK, Jensen MK, Kaplan JL, Kellermayer R, Kelsen JR, Kennedy MA, Khanna S, Knackstedt ED, Lentine J, Lewis JD, Michail S, Mitchell PD, Oliva-Hemker M, Patton T, Queliza K, Sidhu S, Solomon AB, Suskind DL, Weatherly M, Werlin S, de Zoeten EF, Kahn SA. Efficacy and Outcomes of Faecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection in Children with Inflammatory Bowel Disease. J Crohns Colitis. 2022 06 24; 16(5):768-777. PMID: 34788420.
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Constant BD, de Zoeten EF, Stahl MG, Vajravelu RK, Lewis JD, Fennimore B, Gerich ME, Scott FI. Delays Related to Prior Authorization in Inflammatory Bowel Disease. Pediatrics. 2022 03 01; 149(3). PMID: 35190811.
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Constant BD, Dutmer CM, Arnold MA, Hall C, Abbott JK, de Zoeten EF. Cytotoxic T-Lymphocyte-Associated Antigen 4 Haploinsufficiency Mimics Difficult-to-Treat Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2022 04; 20(4):e696-e702. PMID: 33965572.
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Mehta P, Pan Z, Furuta GT, Kim DY, de Zoeten EF. Parent Perspectives on Exclusive Enteral Nutrition for the Treatment of Pediatric Crohn Disease. J Pediatr Gastroenterol Nutr. 2020 12; 71(6):744-748. PMID: 32910623.
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deZoeten EF, Battista KD, Colson SB, Lovell MA, Kessler BE, Isfort RW, Fennimore BP, Onyiah JC, Kao DJ, Yeckes A, Keely S, Murray M, Hoffenberg EJ, Colgan SP, Gerich ME. Markers of Hypoxia Correlate with Histologic and Endoscopic Severity of Colitis in Inflammatory Bowel Disease. Hypoxia (Auckl). 2020; 8:1-12. PMID: 32104717.
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Olbrich CL, Simerly L, de Zoeten EF, Furuta GT, Spencer LA. Climbing New Mountains: How Antibodies Blocking a4?7 Integrins Tamed Eosinophilic Inflammation of the Intestinal Tract. Dig Dis Sci. 2019 08; 64(8):2068-2071. PMID: 31273593.
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Denson LA, Curran M, McGovern DPB, Koltun WA, Duerr RH, Kim SC, Sartor RB, Sylvester FA, Abraham C, de Zoeten EF, Siegel CA, Burns RM, Dobes AM, Shtraizent N, Honig G, Heller CA, Hurtado-Lorenzo A, Cho JH. Challenges in IBD Research: Precision Medicine. Inflamm Bowel Dis. 2019 05 16; 25(Suppl 2):S31-S39. PMID: 31095701.
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Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. Correction: A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 Jun 03; 216(6):1465. PMID: 31088899.
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Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 06 03; 216(6):1255-1267. PMID: 31040184.
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Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF. Corrigendum: C/EBP? Deletion Promotes Expansion of Functionally Poor Intestinal Regulatory T Cells. J Crohns Colitis. 2019 04 26; 13(5):672. PMID: 30624617.
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Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF. C/EBP? Deletion Promotes Expansion of Poorly Functional Intestinal Regulatory T Cells. J Crohns Colitis. 2018 Nov 28; 12(12):1475-1485. PMID: 30085016.
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Sanctuary MR, Huang RH, Jones AA, Luck ME, Aherne CM, Jedlicka P, de Zoeten EF, Collins CB. miR-106a deficiency attenuates inflammation in murine IBD models. Mucosal Immunol. 2019 01; 12(1):200-211. PMID: 30327532.
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Brumbaugh D, de Zoeten E, Dominguez S. Reply. J Pediatr. 2018 May 18. PMID: 29784510.
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Mark J, Fernando SD, Masterson JC, Pan Z, Capocelli KE, Furuta GT, de Zoeten EF. Clinical Implications of Pediatric Colonic Eosinophilia. J Pediatr Gastroenterol Nutr. 2018 05; 66(5):760-766. PMID: 29095349.
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Hoffenberg EJ, McWilliams SK, Mikulich-Gilbertson SK, Murphy BV, Lagueux M, Robbins K, Hoffenberg AS, de Zoeten E, Hopfer CJ. Marijuana Use by Adolescents and Young Adults with Inflammatory Bowel Disease. J Pediatr. 2018 08; 199:99-105. PMID: 29673723.
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Brumbaugh DE, De Zoeten EF, Pyo-Twist A, Fidanza S, Hughes S, Dolan SA, Child J, Dominguez SR. An Intragastric Fecal Microbiota Transplantation Program for Treatment of Recurrent Clostridium difficile in Children is Efficacious, Safe, and Inexpensive. J Pediatr. 2018 03; 194:123-127.e1. PMID: 29198534.
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Leinwand KL, Jones AA, Huang RH, Jedlicka P, Kao DJ, de Zoeten EF, Ghosh S, Moaddel R, Wehkamp J, Ostaff MJ, Bader J, Aherne CM, Collins CB. Cannabinoid Receptor-2 Ameliorates Inflammation in Murine Model of Crohn's Disease. J Crohns Colitis. 2017 Oct 27; 11(11):1369-1380. PMID: 28981653.
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MacManus CF, Collins CB, Nguyen TT, Alfano RW, Jedlicka P, de Zoeten EF. VEN-120, a Recombinant Human Lactoferrin, Promotes a Regulatory T Cell [Treg] Phenotype and Drives Resolution of Inflammation in Distinct Murine Models of Inflammatory Bowel Disease. J Crohns Colitis. 2017 Sep 01; 11(9):1101-1112. PMID: 28472424.
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Noel G, Diamond B, Auerbach S, de Zoeten E, Hoffenberg E. Colonic Crohn Disease After Cardiac Transplantation: Case Report and Literature Review. J Pediatr Gastroenterol Nutr. 2017 08; 65(2):e45-e46. PMID: 26655937.
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Masterson JC, Capocelli KE, Hosford L, Biette K, McNamee EN, de Zoeten EF, Harris R, Fernando SD, Jedlicka P, Protheroe C, Lee JJ, Furuta GT. Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis. Inflamm Bowel Dis. 2015 Oct; 21(10):2429-40. PMID: 26218140.
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Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Erratum: Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 May; 8(3):699. PMID: 25943416.
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Nagy-Szakal D, Mir SA, Harris RA, Dowd SE, Yamada T, Lacorazza HD, Tatevian N, Smith CW, de Zoeten EF, Klein J, Kellermayer R. Loss of n-6 fatty acid induced pediatric obesity protects against acute murine colitis. FASEB J. 2015 Aug; 29(8):3151-9. PMID: 25903104.
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Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 Nov; 8(6):1324-38. PMID: 25850656.
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Shin DS, Jordan A, Basu S, Thomas RM, Bandyopadhyay S, de Zoeten EF, Wells AD, Macian F. Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms. EMBO Rep. 2014 Sep; 15(9):991-9. PMID: 25074018.
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Collins CB, Strassheim D, Aherne CM, Yeckes AR, Jedlicka P, de Zoeten EF. Targeted inhibition of heat shock protein 90 suppresses tumor necrosis factor-a and ameliorates murine intestinal inflammation. Inflamm Bowel Dis. 2014 Apr; 20(4):685-94. PMID: 24552830.
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Furuta GT, Atkins D, Capocelli KE, de Zoeten EF, Fleischer D, Menard-Katcher C. Antitumor necrosis factor, infliximab, and adalimumab: use with caution in eosinophilic bowel disease. J Pediatr Gastroenterol Nutr. 2013 Oct; 57(4):e25. PMID: 23820407.
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Gustafson CE, Higbee D, Yeckes AR, Wilson CC, De Zoeten EF, Jedlicka P, Janoff EN. Limited expression of APRIL and its receptors prior to intestinal IgA plasma cell development during human infancy. Mucosal Immunol. 2014 May; 7(3):467-77. PMID: 24045575.
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de Zoeten EF, Pasternak BA, Mattei P, Kramer RE, Kader HA. Diagnosis and treatment of perianal Crohn disease: NASPGHAN clinical report and consensus statement. J Pediatr Gastroenterol Nutr. 2013 Sep; 57(3):401-12. PMID: 23974063.
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Collins CB, Aherne CM, Ehrentraut SF, Gerich ME, McNamee EN, McManus MC, Lebsack MD, Jedlicka P, Azam T, de Zoeten EF, Dinarello CA, Rivera-Nieves J. Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis. Inflamm Bowel Dis. 2013 Aug; 19(9):1964-73. PMID: 23835442.
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Denson LA, Long MD, McGovern DP, Kugathasan S, Wu GD, Young VB, Pizarro TT, de Zoeten EF, Stappenbeck TS, Plevy SE, Abraham C, Nusrat A, Jobin C, McCole DF, Siegel CA, Higgins PD, Herfarth HH, Hyams J, Sandborn WJ, Loftus EV, Kappelman MD, Lewis JD, Parkos CA, Sartor RB. Challenges in IBD research: update on progress and prioritization of the CCFA's research agenda. Inflamm Bowel Dis. 2013 Mar-Apr; 19(4):677-82. PMID: 23448796.
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Collins CB, Aherne CM, Yeckes A, Pound K, Eltzschig HK, Jedlicka P, de Zoeten EF. Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function. Mucosal Immunol. 2013 Sep; 6(5):960-71. PMID: 23321985.
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Puthoor PR, de Zoeten EF. Pediatric Ulcerative Colitis: The Therapeutic Road to Infliximab. Biol Ther. 2013; 3:1-14. PMID: 24392300.
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Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2784-93. PMID: 22988108.
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Kobayashi T, Matsuoka K, Sheikh SZ, Russo SM, Mishima Y, Collins C, deZoeten EF, Karp CL, Ting JP, Sartor RB, Plevy SE. IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis. J Immunol. 2012 Aug 15; 189(4):1792-9. PMID: 22786766.
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Hunter A, Spechler PA, Cwanger A, Song Y, Zhang Z, Ying GS, Hunter AK, Dezoeten E, Dunaief JL. DNA methylation is associated with altered gene expression in AMD. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2089-105. PMID: 22410570.
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de Zoeten EF, Wang L, Butler K, Beier UH, Akimova T, Sai H, Bradner JE, Mazitschek R, Kozikowski AP, Matthias P, Hancock WW. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May; 31(10):2066-78. PMID: 21444725.
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Friedlander JA, Loeben GS, Finnegan PK, Puma AE, Zhang X, de Zoeten EF, Piccoli DA, Mamula P. A novel method to enhance informed consent: a prospective and randomised trial of form-based versus electronic assisted informed consent in paediatric endoscopy. J Med Ethics. 2011 Apr; 37(4):194-200. PMID: 21245476.
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de Zoeten EF, Wang L, Sai H, Dillmann WH, Hancock WW. Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology. 2010 Feb; 138(2):583-94. PMID: 19879272.
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Wang L, de Zoeten EF, Greene MI, Hancock WW. Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat Rev Drug Discov. 2009 Dec; 8(12):969-81. PMID: 19855427.
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de Zoeten EF, Lee I, Wang L, Chen C, Ge G, Wells AD, Hancock WW, Ozkaynak E. Foxp3 processing by proprotein convertases and control of regulatory T cell function. J Biol Chem. 2009 Feb 27; 284(9):5709-16. PMID: 19117830.
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de Zoeten E, Mamula P. What are the guidelines for using biologics in pediatric patients? Inflamm Bowel Dis. 2008 Oct; 14 Suppl 2:S259-61. PMID: 18816770.
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de Zoeten EF, Markowitz J, Loomes KM, Mamula P, Piccoli DA. A 9-month-old girl with chronic diarrhea. Medscape J Med. 2008; 10(8):195. PMID: 18924647.
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de Zoeten EF, Hancock WW. Strategies to cure experimental autoimmune colitis using antigen-specific Foxp3+ regulatory T cells. Gastroenterology. 2008 Jun; 134(7):2171-4. PMID: 18482583.
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Tao R, de Zoeten EF, Ozkaynak E, Chen C, Wang L, Porrett PM, Li B, Turka LA, Olson EN, Greene MI, Wells AD, Hancock WW. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med. 2007 Nov; 13(11):1299-307. PMID: 17922010.
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Tao R, de Zoeten EF, Ozkaynak E, Wang L, Li B, Greene MI, Wells AD, Hancock WW. Histone deacetylase inhibitors and transplantation. Curr Opin Immunol. 2007 Oct; 19(5):589-95. PMID: 17719760.
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de Zoeten EF, Markovic D, Cohen EP. An optimum anti-melanoma response in mice immunized with fibroblasts transfected with DNA from mouse melanoma cells requires the expression of both syngeneic and allogeneic MHC-determinants. Gene Ther. 2002 Sep; 9(17):1163-72. PMID: 12170380.
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de Zoeten EF, Li D, Cohen EP. Tumor immunity in mice immunized with fibroblasts transfected with tumor DNA. Adv Exp Med Biol. 2001; 495:393-401. PMID: 11774600.
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Glick RP, Lichtor T, de Zoeten E, Deshmukh P, Cohen EP. Prolongation of survival of mice with glioma treated with semiallogeneic fibroblasts secreting interleukin-2. Neurosurgery. 1999 Oct; 45(4):867-74. PMID: 10515482.
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de Zoeten E, Carr-Brendel V, Markovic D, Taylor-Papadimitriou J, Cohen EP. Treatment of breast cancer with fibroblasts transfected with DNA from breast cancer cells. J Immunol. 1999 Jun 01; 162(11):6934-41. PMID: 10352316.
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de Zoeten EF, Carr-Brendel V, Cohen EP. Resistance to melanoma in mice immunized with semiallogeneic fibroblasts transfected with DNA from mouse melanoma cells. J Immunol. 1998 Mar 15; 160(6):2915-22. PMID: 9510195.
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Sun T, Carr-Brendel V, De Zoeten EF, Cohen EP. Immunization with interleukin-2-secreting allogeneic cells transfected with DNA from mouse melanoma cells induces immune responses that prolong the lives of mice with melanoma. Cancer Gene Ther. 1998 Mar-Apr; 5(2):110-8. PMID: 9570302.
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Xu W, de Zoeten E, Carr-Brendel V, Cohen EP. Co-expression of immunogenic determinants by the same cellular immunogen is required for the optimum immunotherapeutic benefit in mice with melanoma. Cancer Immunol Immunother. 1998 Jan; 45(5):217-24. PMID: 9439644.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1998 | 3 | 1999 | 2 | 2001 | 1 | 2002 | 1 | 2007 | 2 | 2008 | 4 | 2009 | 2 | 2011 | 2 | 2012 | 3 | 2013 | 7 | 2014 | 2 | 2015 | 4 | 2017 | 4 | 2018 | 5 | 2019 | 5 | 2020 | 2 | 2021 | 1 | 2022 | 5 | 2023 | 6 |
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